Search Results - "Hancock, Trevor J."
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Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner
Published in PLoS pathogens (01-08-2021)“…Masking the immunogenic cell wall epitope ß(1,3)-glucan under an outer layer of mannosylated glycoproteins is an important virulence factor deployed by Candida…”
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Cek1 regulates ß(1,3)-glucan exposure through calcineurin effectors in Candida albicans
Published in PLoS genetics (19-09-2022)“…In order to successfully induce disease, the fungal pathogen Candida albicans regulates exposure of antigens like the cell wall polysaccharide ß(1,3)-glucan to…”
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Development and characterization of a prototypic pan-amyloid clearing agent – a novel murine peptide-immunoglobulin fusion
Published in Frontiers in immunology (02-10-2023)“…Introduction Systemic amyloidosis is a progressive disorder characterized by the extracellular deposition of amyloid fibrils and accessory proteins in visceral…”
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MCMV Centrifugal Enhancement: A New Spin on an Old Topic
Published in Pathogens (Basel) (03-12-2021)“…Human cytomegalovirus (HCMV) is a ubiquitous pathogen infecting a majority of people worldwide, with diseases ranging from mild to life-threatening. Its…”
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Possible Cross-Reactivity of Feline and White-Tailed Deer Antibodies against the SARS-CoV-2 Receptor Binding Domain
Published in Journal of virology (27-04-2022)“…In late 2019, a novel coronavirus began circulating within humans in central China. It was designated SARS-CoV-2 because of its genetic similarities to the…”
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Neutrophils enhance the clearance of systemic amyloid deposits in a murine amyloidoma model
Published in Frontiers in immunology (12-11-2024)“…Introduction Amyloid-specific antibodies have been shown to opsonize and enhance amyloid clearance in systemic amyloidosis mouse models. However, the…”
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The Human Cytomegalovirus Chemokine vCXCL-1 Modulates Normal Dissemination Kinetics of Murine Cytomegalovirus In Vivo
Published in mBio (25-06-2019)“…Human cytomegalovirus (HCMV) is a betaherpesvirus that is a significant pathogen within newborn and immunocompromised populations. Morbidity associated with…”
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A secreted sirtuin from Campylobacter jejuni contributes to neutrophil activation and intestinal inflammation during infection
Published in Science advances (11-08-2023)“…Histone modifications control numerous processes in eukaryotes, including inflammation. Some bacterial pathogens alter the activity or expression of…”
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Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of In Vitro Screenings
Published in mSphere (13-02-2019)“…Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that can cause severe disease following exposure, during primary infection, or latent virus…”
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Cek1 regulates ß
Published in PLoS genetics (19-09-2022)“…In order to successfully induce disease, the fungal pathogen Candida albicans regulates exposure of antigens like the cell wall polysaccharide ß(1,3)-glucan to…”
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The Human Cytomegalovirus Chemokine vCXCL-1 Modulates Normal Dissemination Kinetics of Murine Cytomegalovirus italic toggle="yes">In Vivo /italic
Published in mBio (01-06-2019)“…ABSTRACT Human cytomegalovirus (HCMV) is a betaherpesvirus that is a significant pathogen within newborn and immunocompromised populations. Morbidity…”
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Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of italic toggle="yes">In Vitro /italic> Screenings
Published in mSphere (01-02-2019)“…ABSTRACT Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that can cause severe disease following in utero exposure, during primary infection, or…”
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