Search Results - "Hancock, Robert E.W."

Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application by Dostert, Melanie, Belanger, Corrie R., Hancock, Robert E.W.

“…Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-threatening infections in humans. At least two-thirds of all…”
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Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections by Kazemzadeh-Narbat, Mehdi, Lai, Benjamin F.L, Ding, Chuanfan, Kizhakkedathu, Jayachandran N, Hancock, Robert E.W, Wang, Rizhi

“…Abstract Prevention of bacterial colonization and formation of a bacterial biofilm on implant surfaces has been a challenge in orthopaedic surgery. The…”
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Therapeutic potential of host defense peptides in antibiotic-resistant infections by Afacan, Nicole J, Yeung, Amy T Y, Pena, Olga M, Hancock, Robert E W

“…The emergence of infections caused by multi-drug resistant (MDR) pathogens pose a major burden to modern healthcare. Exacerbating this issue is the substantial…”
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Potential of immunomodulatory host defense peptides as novel anti-infectives by Easton, Donna M, Nijnik, Anastasia, Mayer, Matthew L, Hancock, Robert E.W

“…A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and…”
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Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs by Cherkasov, Artem, Hilpert, Kai, Jenssen, Håvard, Fjell, Christopher D, Waldbrook, Matt, Mullaly, Sarah C, Volkmer, Rudolf, Hancock, Robert E.W

“…Increased multiple antibiotic resistance in the face of declining antibiotic discovery is one of society’s most pressing health issues. Antimicrobial peptides…”
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The relationship between peptide structure and antibacterial activity by Powers, Jon-Paul S, Hancock, Robert E.W

“…Cationic antimicrobial peptides are a class of small, positively charged peptides known for their broad-spectrum antimicrobial activity. These peptides have…”
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Dismantling the bacterial virulence program by Alford, Morgan A., Pletzer, Daniel, Hancock, Robert E.W.

“…Summary In the face of rising antimicrobial resistance, there is an urgent need for the development of efficient and effective anti‐infective compounds…”
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Cationic peptides: a new source of antibiotics by Hancock, Robert E.W, Lehrer, Robert

“…Antimicrobial cationic peptides are an important component of the innate defenses of all species of life. Different peptides may have antibacterial,…”
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Complexities of targeting innate immunity to treat infection by Brown, Kelly L, Cosseau, Céline, Gardy, Jennifer L, Hancock, Robert E.W

“…Innate immunity is an ancient form of host defence that is activated rapidly to enable, through a multiplicity of effector mechanisms, defence against a broad…”
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The immunology of host defence peptides: beyond antimicrobial activity by Hancock, Robert E.W., Haney, Evan F., Gill, Erin E.

“…Key Points Host defence peptides (HDPs) display substantial immunomodulatory properties in vitro and in vivo , and these features are becoming increasingly…”
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NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data by Xia, Jianguo, Gill, Erin E, Hancock, Robert E W

“…This protocol describes NetworkAnalyst, a web-based tool for performing network analysis and visualization from gene lists and meta-analysis of gene expression…”
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Designing antimicrobial peptides: form follows function by Fjell, Christopher D., Hiss, Jan A., Hancock, Robert E. W., Schneider, Gisbert

“…Key Points Cationic peptides based on natural templates represent one of the most exciting new strategies for developing novel antimicrobials and…”
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Modulating immunity as a therapy for bacterial infections by Hancock, Robert E. W., Nijnik, Anastasia, Philpott, Dana J.

“…Key Points Immunomodulatory therapies for the treatment of bacterial infections act on the host rather than the pathogen and are intended for use as adjunctive…”
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Host defense peptides: front-line immunomodulators by Mansour, Sarah C, Pena, Olga M, Hancock, Robert E.W

“…Highlights • The most relevant biological role of host defense peptides is immunomodulation. • These immunomodulatory functions are therapeutic in several…”
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Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection by Brown, Tyler H.T, David, Jason, Acosta-Ramirez, Elizabeth, Moore, Jessica M, Lee, Song, Zhong, Guangming, Hancock, Robert E.W, Xing, Zhou, Halperin, Scott A, Wang, Jun

“…Highlights ► An adenovirus-based vaccine expressing CPAF antigen (AdCPAF) is developed. ► We compared the immune responses induced by different vaccination…”
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Antimicrobial Peptides: An Introduction by Haney, Evan F, Mansour, Sarah C, Hancock, Robert E W

“…The "golden era" of antibiotic discovery has long passed, but the need for new antibiotics has never been greater due to the emerging threat of antibiotic…”
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Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model by Yu, Kai, Lo, Joey, Yan, Mei, Yang, Xiaoqiang, Brooks, Donald E, Hancock, Robert E.W, Lange, Dirk, Kizhakkedathu, Jayachandran N

“…Abstract Catheter-associated urinary tract infections (CAUTIs) represent one of the most common hospital acquired infections with significant economic…”
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Novel roles for two-component regulatory systems in cytotoxicity and virulence-related properties in Pseudomonas aeruginosa by Gellatly, Shaan L, Bains, Manjeet, Breidenstein, Elena B M, Strehmel, Janine, Reffuveille, Fany, Taylor, Patrick K, Yeung, Amy T Y, Overhage, Joerg, Hancock, Robert E W

“…The rapid adaptation of the opportunistic bacterial pathogen to various growth modes and environmental conditions is controlled in part through diverse…”
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Broad-spectrum anti-biofilm peptide that targets a cellular stress response by de la Fuente-Núñez, César, Reffuveille, Fany, Haney, Evan F, Straus, Suzana K, Hancock, Robert E W

“…Bacteria form multicellular communities known as biofilms that cause two thirds of all infections and demonstrate a 10 to 1000 fold increase in adaptive…”
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Action of lysozyme and nisin mixtures against lactic acid bacteria by Chung, Wilfred, Hancock, Robert E.W

“…Lysozyme was formulated together with nisin for usage against food spoilage lactobacilli. The mixtures demonstrated improved minimal inhibitory concentrations…”
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