Search Results - "Hancock, Paula"
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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
Published in Biochemical journal (15-01-2005)“…We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their…”
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Quantitative evaluation of siRNA delivery in vivo
Published in RNA (Cambridge) (01-12-2010)“…Effective small interfering RNA (siRNA)-mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC)…”
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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members
Published in Molecular cancer therapeutics (01-02-2005)“…Recent studies indicate that dysregulation of the Akt/PKB family of serine/threonine kinases is a prominent feature of many human cancers. The Akt/PKB family…”
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Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen
Published in ACS medicinal chemistry letters (14-01-2021)“…By employing a phenotypic screen, a set of compounds, exemplified by , were identified which potentiate the ability of histone deacetylase inhibitor vorinostat…”
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RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice
Published in Molecular pharmacology (01-06-2011)“…Deeper knowledge of pharmacokinetic and pharmacodynamic (PK/PD) concepts for RNA therapeutics is important to streamline the drug development process and for…”
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The Crystal Structure of Human Protein Farnesyltransferase Reveals the Basis for Inhibition by CaaX Tetrapeptides and Their Mimetics
Published in Proceedings of the National Academy of Sciences - PNAS (06-11-2001)“…Protein farnesyltransferase (FTase) catalyzes the attachment of a farnesyl lipid group to the cysteine residue located in the C-terminal tetrapeptide of many…”
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Mentors need appropriate resources and training
Published in Nursing standard (14-09-2011)Get full text
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Mentors need appropriate resources and training
Published in Nursing standard (14-09-2011)Get full text
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Current Issues in Nursing – Eighth editionCurrent Issues in Nursing – Eighth edition
Published in Nursing standard (05-01-2011)Get full text
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Nurses on the Run – Why They Come, Why They StayNurses on the Run – Why They Come, Why They Stay
Published in Nursing standard (17-11-2010)Get full text
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Harmonising teaching across the continent: Paula Hancock has developed a Europe-wide occupational health nursing qualification
Published in Nursing standard (04-11-2009)Get full text
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P2-091: Instrumental Activities of Daily Living (IADL) Scale in the diagnosis of dementia
Published in Alzheimer's & dementia (01-07-2006)Get full text
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P3-014: Utility of Pittsburgh Sleep Quality Index as a diagnostic instrument to differentiate dementia from “not-dementia” in memory clinics
Published in Alzheimer's & dementia (01-07-2008)Get full text
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Cambridge Behavioural Inventory for the diagnosis of dementia
Published in Progress in neurology and psychiatry (Guildford) (01-09-2008)“…The Cambridge Behavioural Inventory (CBI) is a short, self‐administered informant questionnaire developed to distinguish between the behavioural and…”
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Issues of qualification assessment for nurses in a global market
Published in Nurse education today (01-01-2002)Get full text
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Reflective practice--using a learning journal
Published in Nursing standard (13-01-1999)“…Reflective practice learning journals have become a valued teaching and learning tool in nurse education, particularly for nursing students from other…”
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International recruitment. Quick fix or long-term investment
Published in Nursing management (Harrow, London, England) (01-06-2002)“…Recruiting nurses trained in other countries is central to the government's recruitment and retention strategy. Explains how the experience need not be…”
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Current Issues in Nursing--Eighth edition
Published in Nursing standard (05-01-2011)Get full text
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Nurses on the Run--Why They Come, Why They Stay
Published in Nursing standard (17-11-2010)Get full text
Book Review Journal Article