Search Results - "Hancock, Erin N."

Ladderane Natural Products: From the Ground Up by Hancock, Erin N., Brown, M. Kevin

“…The ladderane family of natural products are well known for their linearly concatenated cyclobutane skeletal structure. Owing to their unique carbocyclic…”
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Recent advances in the synthesis of gem-dimethylcyclobutane natural products by Hancock, Erin N, Wahl, Johannes M, Brown, M Kevin

“…Covering: January 2000 to July 2018 gem-Dimethylcyclobutanes are a common motif found in a multitude of natural products, and thus these structures have…”
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[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes by Epplin, Rachel C., Paul, Shashwati, Herter, Loïc, Salome, Christophe, Hancock, Erin N., Larrow, Jay F., Baum, Erich W., Dunstan, David R., Ginsburg-Moraff, Carol, Fessard, Thomas C., Brown, M. Kevin

“…Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of…”
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Synthesis of ent-[3]-Ladderanol: Development and Application of Intramolecular Chirality Transfer [2+2] Cycloadditions of Allenic Ketones and Alkenes by Line, Nathan J, Witherspoon, Brittany P, Hancock, Erin N, Brown, M. Kevin

“…An enantioselective synthesis of ent-[3]-ladderanol is presented. The ladderanes are an interesting class of molecules for their unique structure of fused…”
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Lessons in Strain and Stability: Enantioselective Synthesis of (+)‐[5]‐Ladderanoic Acid by Hancock, Erin N., Kuker, Erin L., Tantillo, Dean J., Brown, M. Kevin

“…The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new…”
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From UK-2A to florylpicoxamid: Active learning to identify a mimic of a macrocyclic natural product by Cleves, Ann E., Jain, Ajay N., Demeter, David A., Buchan, Zachary A., Wilmot, Jeremy, Hancock, Erin N.

“…Scaffold replacement as part of an optimization process that requires maintenance of potency, desirable biodistribution, metabolic stability, and…”
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Lessons in Strain and Stability: Enantioselective Synthesis of (+)‐[5]‐Ladderanoic Acid by Hancock, Erin N., Kuker, Erin L., Tantillo, Dean J., Brown, M. Kevin

“…The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new…”
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Lessons in Strain and Stability: Enantioselective Synthesis of (+)-5-Ladderanoic Acid by Hancock, Erin N, Kuker, Erin L, Tantillo, Dean J, Brown, M Kevin

“…The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new…”
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