Search Results - "Hancock, Arthur A."

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention by Cowart, Marlon, Faghih, Ramin, Curtis, Michael P, Gfesser, Gregory A, Bennani, Youssef L, Black, Lawrence A, Pan, Liping, Marsh, Kennan C, Sullivan, James P, Esbenshade, Timothy A, Fox, Gerard B, Hancock, Arthur A

“…H3 receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and rat H3 receptors, with K i…”
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Perspectives on cognitive domains, H3 receptor ligands and neurological disease by Hancock, Arthur A, Fox, Gerard B

“…Histamine H(3) receptor agonists and antagonists have been evaluated in numerous in vitro and in vivo animal models to better understand how H(3) receptors…”
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A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans by COWART, Marion, PRATT, John K, STEWART, Andrew O, BENNANI, Youssef L, ESBENSHADE, Timothy A, HANCOCK, Arthur A

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Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization by Fox, Gerard B, Pan, Jia Bao, Radek, Richard J, Lewis, Angela M, Bitner, R Scott, Esbenshade, Timothy A, Faghih, Ramin, Bennani, Youssef L, Williams, Michael, Yao, Betty B, Decker, Michael W, Hancock, Arthur A

“…Pharmacological blockade of central histamine H3 receptors (H3Rs) enhances cognition in rodents and offers promise for the clinical treatment of neurological…”
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Effects of histamine H3 receptor antagonists in two models of spatial learning by KOMATER, Victoria A, BUCKLEY, Michael J, BROWMAN, Kaitlin E, JIA BAO PAN, HANCOCK, Arthur A, DECKER, Michael W, FOX, Gerard B

“…Despite the well-described attention and short-term memory enhancing effects of H3 receptor antagonists, and evidence to suggest a close relationship between…”
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An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity by Bongers, Gerold, Krueger, Kathleen M, Miller, Thomas R, Baranowski, John L, Estvander, Brian R, Witte, David G, Strakhova, Marina I, van Meer, Peter, Bakker, Remko A, Cowart, Marlon D, Hancock, Arthur A, Esbenshade, Timothy A, Leurs, Rob

“…In this article, we pharmacologically characterized two naturally occurring human histamine H3 receptor (hH3R) isoforms, hH3R(445) and hH3R(365). These…”
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Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects by Esbenshade, Timothy A, Krueger, Kathleen M, Miller, Thomas R, Kang, Chae Hee, Denny, Lynne I, Witte, David G, Yao, Betty B, Fox, Gerard B, Faghih, Ramin, Bennani, Youssef L, Williams, Michael, Hancock, Arthur A

“…Histamine H3 receptor (H3R) antagonists enhance neurotransmitter release and are being developed for the treatment of a variety of neurological and cognitive…”
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Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup by FOX, Gerard B, JIA BAO PAN, ESBENSHADE, Timothy A, BENNANI, Youssef L, BLACK, Lawrence A, FAGHIH, Ramin, HANCOCK, Arthur A, DECKER, Michael W

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Structure–activity relationships of arylbenzofuran H3 receptor antagonists by Gfesser, Gregory A., Faghih, Ramin, Bennani, Youssef L., Curtis, Michael P., Esbenshade, Timothy A., Hancock, Arthur A., Cowart, Marlon D.

“…An SAR study of histamine H3 receptor antagonists based on substituted (R)-2-methyl-1-[2-(5-phenyl-benzofuran-2-yl)-ethyl]-pyrrolidines is presented. An SAR…”
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Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist by ESBENSHADE, Timothy A, FOX, Gerard B, FAGHIH, Ramin, BENNANI, Youssef L, WILLIAMS, Michael, HANCOCK, Arthur A, KRUEGER, Kathleen M, BARANOWSKI, John L, MILLER, Thomas R, CHAE HEE KANG, DENNY, Lynne I, WITTE, David G, YAO, Betty B, JIA BAO PAN

“…Histamine H3 receptors regulate the release of a variety of central neurotransmitters involved in cognitive processes. A-349821…”
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Enhancement of prepulse inhibition of startle in mice by the H3 receptor antagonists thioperamide and ciproxifan by BROWMAN, Kaitlin E, KOMATER, Victoria A, CURZON, Peter, RUETER, Lynne E, HANCOCK, Arthur A, DECKER, Michael W, FOX, Gerard B

“…Histamine H3 receptor antagonists/inverse agonists have been proposed as potential therapeutic agents for the treatment of a number of neurological disorders…”
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G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations by Krueger, Kathleen M, Witte, David G, Ireland-Denny, Lynne, Miller, Thomas R, Baranowski, John L, Buckner, Steve, Milicic, Ivan, Esbenshade, Timothy A, Hancock, Arthur A

“…Previously reported pharmacological studies using the imidazole-containing histamine H3 receptor ligands GT-2331 (Cipralisant) and proxyfan resulted in a range…”
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Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships by Zhao, Chen, Sun, Minghua, Bennani, Youssef L, Miller, Thomas R, Witte, David G, Esbenshade, Timothy A, Wetter, Jill, Marsh, Kennan C, Hancock, Arthur A, Brioni, Jorge D, Cowart, Marlon D

“…A new histamine H3 receptor (H3R) antagonist chemotype 1 was designed by combining key pharmacophoric elements from two different precursor structural series…”
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In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists : Trends across multiple chemical series by NERSESIAN, Diana L, BLACK, Lawrence A, MILLER, Thomas R, VORTHERMS, Timothy A, ESBENSHADE, Timothy A, HANCOCK, Arthur A, COWART, Marlon D

“…Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were…”
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An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration by Liu, Huaqing, Kerdesky, Francis A, Black, Lawrence A, Fitzgerald, Michael, Henry, Rodger, Esbenshade, Timothy A, Hancock, Arthur A, Bennani, Youssef L

“…GT-2331 is a potent histamine H3 antagonist which has entered clinical trials. Efficient multigram syntheses of this compound and its enantiomer are described…”
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Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists by FAGHIH, Ramin, DWIGHT, Wesley, JIA BAO PAN, FOX, Gerard B, KRUEGER, Kathy M, ESBENSHADE, Timothy A, MCVEY, Jill M, MARSH, Kennan, BENNANI, Youssef L, HANCOCK, Arthur A

“…Novel 4'-[(NR1R2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most…”
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Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model by FOX, Gerard B, JIA BAO PAN, HANCOCK, Arthur A, DECKER, Michael W, ESBENSHADE, Timothy A, BITNER, R. Scott, NIKKEL, Arthur L, MILLER, Tom, CHAE HEE KANG, BENNANI, Youssef L, BLACK, Lawrence A, FAGHIH, Ramin

“…The selective H(3) receptor agonist (R)-alpha-methylhistamine [(R)-alpha-MeHA] stimulates drinking in the adult rat. In the present study, we investigated the…”
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Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor by Witte, David G, Cassar, Steven C, Masters, Jeffrey N, Esbenshade, Timothy, Hancock, Arthur A

“…The cloned vanilloid receptor 1 (VR1) is a ligand-gated calcium channel that is believed to be the capsaicin-activated vanilloid receptor found in native…”
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Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist by Esbenshade, Timothy A, Browman, Kaitlin E, Miller, Thomas R, Krueger, Kathleen M, Komater-Roderwald, Victoria, Zhang, Min, Fox, Gerard B, Rueter, Lynne, Robb, Holly M, Radek, Richard J, Drescher, Karla U, Fey, Thomas A, Bitner, R Scott, Marsh, Kennan, Polakowski, James S, Zhao, Chen, Cowart, Marlon D, Hancock, Arthur A, Sullivan, James P, Brioni, Jorge D

“…Blockade of the histamine H(3) receptor (H(3)R) enhances central neurotransmitter release, making it an attractive target for the treatment of cognitive…”
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Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist by Fox, Gerard B, Esbenshade, Timothy A, Pan, Jia Bao, Radek, Richard J, Krueger, Kathleen M, Yao, Betty B, Browman, Kaitlin E, Buckley, Michael J, Ballard, Michael E, Komater, Victoria A, Miner, Holly, Zhang, Min, Faghih, Ramin, Rueter, Lynne E, Bitner, R Scott, Drescher, Karla U, Wetter, Jill, Marsh, Kennan, Lemaire, Martine, Porsolt, Roger D, Bennani, Youssef L, Sullivan, James P, Cowart, Marlon D, Decker, Michael W, Hancock, Arthur A

“…Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is little information available…”
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