Search Results - "Hanck, D A"

Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms by Fozzard, H A, Hanck, D A

“…Cardiac and nerve Na channels have broadly similar functional properties and amino acid sequences, but they demonstrate specific differences in gating,…”
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Isoform-dependent interaction of voltage-gated sodium channels with protons by Khan, A., Kyle, J. W., Hanck, D. A., Lipkind, G. M., Fozzard, H. A.

“…Protons are potent physiological modifiers of voltage-gated Na + channels, shifting the voltage range of channel gating and reducing current magnitude (p K a…”
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Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells by Hanck, D A, Sheets, M F

“…The spontaneous hyperpolarizing shift in Na+ channel kinetics that occurs during a series of voltage-clamp recordings was characterized in single canine…”
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Mechanism of cAMP-Dependent Modulation of Cardiac Sodium Channel Current Kinetics by Ono, Katsushige, Fozzard, Harry A, Hanck, Dorothy A

“…β-Adrenergic modulation is one of the most important regulatory mechanisms of ion channel function. Only recently, however, have β-adrenergic effects on…”
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Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells by Hanck, D A, Sheets, M F

“…1. The effects of the extracellular divalent cations barium, calcium, cadmium, cobalt, magnesium, manganese, nickel and zinc and the trivalent cation lanthanum…”
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Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells by Sheets, M F, Hanck, D A

“…1. Single canine cardiac Purkinje cells were internally perfused and voltage clamped with a large-bore perfusion pipette for measurement of sodium ionic…”
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Dose-Dependent Modulation of the Cardiac Sodium Channel by Sea Anemone Toxin ATXII by El-Sherif, Nabil, Fozzard, Harry A, Hanck, Dorothy A

“…The effects of sea anemone toxin ATXII on single sodium channels were studied in cell-attached patches on rabbit ventricular myocytes at 20–22°C. Exposure of…”
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Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells by SHEETS, M. F, HANCK, D. A, FOZZARD, H. A

“…We studied the relation of the maximal upstroke velocity (Vmax) of action potentials to the peak sodium current (INa) under voltage clamp in single, internally…”
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Optimization of a mammalian expression system for the measurement of sodium channel gating currents by Sheets, M F, Kyle, J W, Krueger, S, Hanck, D A

“…We describe a new mammalian expression system that optimizes conditions for the measurement of Na channel gating currents (Ig). The small magnitude of Ig…”
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Kinetic analysis of single sodium channels from canine cardiac Purkinje cells by SCANLEY, B. E, HANCK, D. A, CHAY, T, FOZZARD, H. A

“…Single sodium channel events were recorded from cell-attached patches on single canine cardiac Purkinje cells at 10-13 degrees C. Data from four patches…”
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Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin by Martin, R.L, Pittendrigh, B, Liu, J, Reenan, R, ffrench-Constant, R, Hanck, D.A

“…Voltage-gated sodium channels are the presumed site of action of pyrethroid insecticides and DDT. We screened several mutant sodium channel Drosophila lines…”
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Mibefradil block of cloned T-type calcium channels by Martin, R L, Lee, J H, Cribbs, L L, Perez-Reyes, E, Hanck, D A

“…Mibefradil is a tetralol derivative chemically distinct from other calcium channel antagonists. It is a very effective antihypertensive agent that is thought…”
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Is there a second external lidocaine binding site on mammalian cardiac cells? by Alpert, L A, Fozzard, H A, Hanck, D A, Makielski, J C

“…Lidocaine and its permanently charged analogue QX-314 block sodium current (INa) in nerve, and by this mechanism, lidocaine produces local anesthesia. When…”
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A Structural Motif for the Voltage-Gated Potassium Channel Pore by Lipkind, Gregory M., Hanck, Dorothy A., Fozzard, Harry A.

“…Mutation studies have identified a region of the S5-S6 loop of voltage-gated K+channels (P region) responsible for tetraethylammonium (TEA) block and…”
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Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8 by Zeng, D, Kyle, J W, Martin, R L, Ambler, K S, Hanck, D A

“…RT4-B is one of several cell lines derived from a multipotent stem cell line, RT4-AC, which originated from a rat peripheral neurotumor. Based on Northern blot…”
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Effect of external Ca2+ concentration on stretch-augmented natriuretic peptide secretion by rat atria by Page, E, Upshaw-Earley, J, Goings, G E, Hanck, D A

“…An in vitro noncontracting rat atrial preparation stretched at 37 degrees C by a distending pressure of 5.1 mmHg was used to examine effects of external Ca2+…”
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Gating currents associated with Na channels in canine cardiac Purkinje cells by HANCK, D. A, SHEETS, M. F, FOZZARD, H. A

“…Gating currents (Ig) were recorded in single canine cardiac Purkinje cells at 10-12 degrees C. Ig characteristics corresponded closely to macroscopic INa…”
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Inhibition of atrial peptide secretion at different stages of the secretory process: Ca2+ dependence by Page, E, Upshaw-Earley, J, Goings, G E, Hanck, D A

“…We have used a noncontracting in vitro preparation of stretched and unstretched rat atria to estimate contributions of constitutive and regulated pathways to…”
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The Na Channel Voltage Sensor Associated with Inactivation Is Localized to the External Charged Residues of Domain IV, S4 by Sheets, Michael F., Kyle, John W., Kallen, Roland G., Hanck, Dorothy A.

“…Site-3 toxins have been shown to inhibit a component of gating charge (33% of maximum gating charge, Q max) in native cardiac Na channels that has been…”
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Fluid-phase endocytosis by in situ cardiac myocytes of rat atria by Page, E, Upshaw-Earley, J, Goings, G E, Hanck, D A

“…Fluid-phase endocytosis (FPE) associated with recycling of fused plasmalemma-secretory granules or membranes and/or membrane receptors by in situ cardiac…”
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