Search Results - "Hanau, Cathleen E"

Discovery of N‑(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)‑5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)‑2H‑tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis by Ruminski, Peter G, Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E, Schmidt, Michelle, Scholten, Jeffrey A, Fletcher, Theresa R, Hamper, Bruce C, Carroll, Jeffery N, Shieh, Huey S, Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E, Collins, Joe, Baldus, John E, Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D, McDonald, Joseph, Munie, Grace E, Messing, Dean M, Portolan, Silvia, Whiteley, Laurence O, Sunyer, Teresa, Schnute, Mark E

“…Matrix metalloproteinase-13 (MMP-13) is a zinc-dependent protease responsible for the cleavage of type II collagen, the major structural protein of articular…”
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Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design by Walker, Daniel P., Arhancet, Graciela B., Lu, Hwang-Fun, Heasley, Steven E., Metz, Sue, Kablaoui, Natasha M., Franco, Francisco M., Hanau, Cathleen E., Scholten, Jeffrey A., Springer, John R., Fobian, Yvette M., Carter, Jeffrey S., Xing, Li, Yang, Shengtian, Shaffer, Alexander F., Jerome, Gina M., Baratta, Michael T., Moore, William M., Vazquez, Michael L.

“…Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. In the preceding letter, we detailed…”
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Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis by SCHNUTE, Mark E, O'BRIEN, Patrick M, CARROLL, Jeffery N, PATT, William C, SHIEH, Huey S, COLLINS, Brandon, PAVLOVSKY, Alexander G, PALMQUIST, Katherine E, ASTON, Karl W, HITCHCOCK, Jeffrey, ROGERS, Michael D, MCDONALD, Joseph, NAHRA, Joe, JOHNSON, Adam R, MUNIE, Grace E, WITTWER, Arthur J, MAN, Chiu-Fai, SETTLE, Steven L, NEMIROVSKIY, Olga, VICKERY, Lillian E, AGAWAL, Arun, DYER, Richard D, SUNYER, Teresa, MORRIS, Mark, HOWARD ROARK, W, HANAU, Cathleen E, RUMINSKI, Peter G, SCHOLTEN, Jeffrey A, FLETCHER, Theresa R, HAMPER, Bruce C

“…Potent, highly selective and orally-bioavailable MMP-13 inhibitors have been identified based upon a (pyridin-4-yl)-2H-tetrazole scaffold. Co-crystal structure…”
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Conformationally Restricted Peptide Mimetics: The Incorporation of 6,5-Bicyclic Lactam Ring Skeletons into Peptides by Li, Wenhao, Hanau, Cathleen E, dAvignon, Andre, Moeller, Kevin D

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Discovery of N -(4-Fluoro-3-methoxybenzyl)-6-(2-(((2 S ,5 R )-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2 H -tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis by Ruminski, Peter G., Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E., Schmidt, Michelle, Scholten, Jeffrey A., Fletcher, Theresa R., Hamper, Bruce C., Carroll, Jeffery N., Shieh, Huey S., Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E., Collins, Joe, Baldus, John E., Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D., McDonald, Joseph, Munie, Grace E., Messing, Dean M., Portolan, Silvia, Whiteley, Laurence O., Sunyer, Teresa, Schnute, Mark E.

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Discovery of (pyridin-4-yl)-2 H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis by Schnute, Mark E., O’Brien, Patrick M., Nahra, Joe, Morris, Mark, Howard Roark, W., Hanau, Cathleen E., Ruminski, Peter G., Scholten, Jeffrey A., Fletcher, Theresa R., Hamper, Bruce C., Carroll, Jeffery N., Patt, William C., Shieh, Huey S., Collins, Brandon, Pavlovsky, Alexander G., Palmquist, Katherine E., Aston, Karl W., Hitchcock, Jeffrey, Rogers, Michael D., McDonald, Joseph, Johnson, Adam R., Munie, Grace E., Wittwer, Arthur J., Man, Chiu-Fai, Settle, Steven L., Nemirovskiy, Olga, Vickery, Lillian E., Agawal, Arun, Dyer, Richard D., Sunyer, Teresa

“…Potent, highly selective and orally-bioavailable MMP-13 inhibitors have been identified which inhibit production of type II collagen neoepitope (TIINE), a…”
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