Search Results - "Hanash, S. M."

Identification of novel targets for cancer therapy using expression proteomics by HANASH, S. M, MADOZ-GURPIDE, J, MISEK, D. E

“…Although most drugs target proteins, the proteome has remained largely untapped for the discovery of drug targets. The sequencing of the human genome has had a…”
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Whole-genome methylation scan in ICF syndrome : hypomethylation of non-satellite DNA repeats D4Z4 and NBL2 by KONDO, T, BOBEK, M. P, KUICK, R, LAMB, B, XIAOXIANG ZHU, NARAYAN, A, BOURC'HIS, D, VIEGAS-PEQUIGNOT, E, EHRLICH, M, HANASH, S. M

“…The ICF (immunodeficiency, centromeric instability and facial abnormalities) syndrome is a rare recessive disease characterized by immunodeficiency,…”
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Arcuate Nucleus Transcriptome Profiling Identifies Ankyrin Repeat and Suppressor of Cytokine Signalling Box-Containing Protein 4 as a Gene Regulated by Fasting in Central Nervous System Feeding Circuits by Li, J.-Y., Kuick, R., Thompson, R. C., Misek, D. E., Lai, Y.-M., Liu, Y.-Q., Chai, B.-X., Hanash, S. M., Gantz, I.

“…The arcuate nucleus of the hypothalamus is a primary site for sensing blood borne nutrients and hormonal messengers that reflect caloric status. To identify…”
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Quantitative analysis of Op18 phosphorylation in childhood acute leukemia by MELHEM, R, HAILAT, N, KUICK, R, HANASH, S. M

“…Oncoprotein 18 (Op18) is a major cystolic phosphoprotein constituent of leukemia cells. There is cumulative evidence that suggests a role for Op18 in…”
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Co-amplification of a novel gene, NAG, with the N-myc gene in neuroblastoma by WIMMER, K, ZHU, X. X, LAMB, B. J, KUICK, R, AMBROS, P. F, KOVAR, H, THORAVAL, D, MOTYKA, S, ALBERTS, J. R, HANASH, S. M

“…Substantial evidence implicates amplification of the N-myc gene with aggressive tumor growth and poor outcome in neuroblastoma. However some evidence suggests…”
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Proliferation-related expression of p19/nm23 nucleoside diphosphate kinase by KEIM, D, HAILAT, N, MELHEM, R, ZHU, X. X, LASCU, I, VERON, M, STRAHLER, J, HANASH, S. M

“…High level expression of the nm23-H1 gene, which encodes for a nucleoside diphosphate kinase, has been found to correlate with diminished metastasis in some…”
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Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients by Grolleau, A, Kaplan, M J, Hanash, S M, Beretta, L, Richardson, B

“…Activation of peripheral blood T cells results in a rapid and substantial rise in translation rates and proliferation, but proliferation in response to mitogen…”
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Identification of a polypeptide associated with the malignant phenotype in acute leukemia by Hanash, S M, Strahler, J R, Kuick, R, Chu, E H, Nichols, D

“…A novel polypeptide, designated p18, was detected in a variety of hematopoietic cells by two-dimensional polyacrylamide gel electrophoresis. Quantitative…”
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Insulin-like growth factor II in the pathogenesis of human neuroblastoma by Sullivan, KA, Castle, VP, Hanash, SM, Feldman, EL

“…Insulin-like growth factor II (IGF-II) acts as an autocrine growth factor for many in vitro tumor cell lines including neuroblastoma. To examine the role of…”
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High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification by HAILAT, N, KEIM, D. R, HANASH, S. M, MELHEM, R. F, XIAO-XIANG ZHU, ECKERSKORN, C, BRODEUR, G. M, REYNOLDS, C. P, SEEGER, R. C, LOTTSPEICH, F, STRAHLER, J. R

“…The gene encoding a novel protein designated nm23-H1, which was recently identified as identical to the A subunit of nucleotide diphosphate kinase from human…”
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Operomics: molecular analysis of tissues from DNA to RNA to protein by Hanash, S M

“…The identification of coding sequences in a number of species, including human in the near future, has ushered in the post-genome era. In this era,…”
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Characterization of the gene for a proliferation-related phosphoprotein (oncoprotein 18) expressed in high amounts in acute leukemia by MELHEM, R. F, XIAO-XIANG ZHU, HALIAT, N, STRAHLER, J. R, HANASH, S. M

“…The oncoprotein 18 (Op18) gene encodes a proliferation-related cytosolic phosphoprotein, which is induced in normal lymphocytes following mitogenic…”
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Proteomics-based Identification of RS/DJ-1 as a Novel Circulating Tumor Antigen in Breast Cancer by Le Naour, F, Misek, D E, Krause, M C, Deneux, L, Giordano, T J, Scholl, S, Hanash, S M

“…Purpose: We used a proteomics-based approach to identify tumor proteins that elicit a humoral response in breast carcinoma and that may occur as circulating…”
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Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis by RICKMAN, David S, BOBEK, Miroslav P, MISEK, David E, KUICK, Rork, BLAIVAS, Mila, KURNIT, David M, TAYLOR, Jeremy, HANASH, Samir M

“…Astrocytomas are heterogeneous intracranial glial neoplasms ranging from the highly aggressive malignant glioblastoma multiforme (GBM) to the indolent,…”
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The major CD9 and CD81 molecular partner. Identification and characterization of the complexes by Charrin, S, Le Naour, F, Oualid, M, Billard, M, Faure, G, Hanash, S M, Boucheix, C, Rubinstein, E

“…By associating with specific partner molecules and with each other, the tetraspanins are thought to assemble multimolecular complexes that may be especially…”
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Protein Profiles Associated with Survival in Lung Adenocarcinoma by Chen, Guoan, Gharib, Tarek G., Wang, Hong, Huang, Chiang-Ching, Kuick, Rork, Thomas, Dafydd G., Shedden, Kerby A., Misek, David E., Jeremy M. G. Taylor, Giordano, Thomas J., Sharon L. R. Kardia, Iannettoni, Mark D., Yee, John, Hogg, Philip J., Orringer, Mark B., Hanash, Samir M., Beer, David G.

“…Morphologic assessment of lung tumors is informative but insufficient to adequately predict patient outcome. We previously identified transcriptional profiles…”
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Involvement of OP18 in cell proliferation by Melhem, R F, Strahler, J R, Hailat, N, Zhu, X X, Hanash, S M

“…Op18 is a highly conserved major cytosolic phosphoprotein that is expressed at high levels in acute leukemia and in neuroblastoma. In this study we present…”
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An Immune Response Manifested by the Common Occurrence of Annexins I and II Autoantibodies and High Circulating Levels of IL-6 in Lung Cancer by Brichory, Franck M., Misek, David E., Yim, Anne-Marie, Krause, Melissa C., Giordano, Thomas J., Beer, David G., Hanash, Samir M.

“…The identification of circulating tumor antigens or their related autoantibodies provides a means for early cancer diagnosis as well as leads for therapy. The…”
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A role for chromosome 1 in colorectal cancer by Hanash, SM

“…This article has no abstract. To view the article, select the "View Print Version (PDF)" link above…”
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Molecular cloning of a novel human leukemia-associated gene. Evidence of conservation in animal species by XIAO-XIANG ZHU, KOZARSKY, K, STRAHLER, J. R, ECKERSKORN, C, LOTTSPEICH, F, MELHEM, R, LOWE, J, FOX, D. A, HANASH, S. M, ATWEH, G. F

“…We have recently described an 18-kilodalton polypeptide (p18) that is present in much greater abundance in acute leukemic blast cells (myeloid and lymphoid)…”
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