Search Results - "Hanaoka, Kenjiro"

Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy by Piao, Wen, Hanaoka, Kenjiro, Fujisawa, Tomotsumi, Takeuchi, Satoshi, Komatsu, Toru, Ueno, Tasuku, Terai, Takuya, Tahara, Tahei, Nagano, Tetsuo, Urano, Yasuteru

“…Photodynamic therapy (PDT) utilizes photoirradiation in the presence of photosensitizers to ablate cancer cells via generation of singlet oxygen (1O2), but it…”
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Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling by Takano, Yoko, Echizen, Honami, Hanaoka, Kenjiro

“…Hydrogen sulfide (H S) plays roles in many physiological processes, including relaxation of vascular smooth muscles, mediation of neurotransmission, inhibition…”
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Evolution of Group 14 Rhodamines as Platforms for Near-Infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer by Koide, Yuichiro, Urano, Yasuteru, Hanaoka, Kenjiro, Terai, Takuya, Nagano, Tetsuo

“…The absorption and emission wavelengths of group 14 pyronines and rhodamines, which contain silicon, germanium, or tin at the 10 position of the xanthene…”
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General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process by Hanaoka, Kenjiro, Iwaki, Shimpei, Yagi, Kiyoshi, Myochin, Takuya, Ikeno, Takayuki, Ohno, Hisashi, Sasaki, Eita, Komatsu, Toru, Ueno, Tasuku, Uchigashima, Motokazu, Mikuni, Takayasu, Tainaka, Kazuki, Tahara, Shinya, Takeuchi, Satoshi, Tahara, Tahei, Uchiyama, Masanobu, Nagano, Tetsuo, Urano, Yasuteru

“…Fluorogenic probes for bioimaging have become essential tools for life science and medicine, and the key to their development is a precise understanding of the…”
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Development and Application of a Near-Infrared Fluorescence Probe for Oxidative Stress Based on Differential Reactivity of Linked Cyanine Dyes by Oushiki, Daihi, Kojima, Hirotatsu, Terai, Takuya, Arita, Makoto, Hanaoka, Kenjiro, Urano, Yasuteru, Nagano, Tetsuo

“…Reactive oxygen species (ROS) operate as signaling molecules under various physiological conditions, and overproduction of ROS is involved in the pathogenesis…”
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Design of Photostable, Activatable Near‐Infrared Photoacoustic Probes Using Tautomeric Benziphthalocyanine as a Platform by Toriumi, Naoyuki, Asano, Norihito, Ikeno, Takayuki, Muranaka, Atsuya, Hanaoka, Kenjiro, Urano, Yasuteru, Uchiyama, Masanobu

“…Near‐infrared (NIR) imaging techniques have attracted significant attention for biological and medicinal applications due to the ability of NIR to penetrate…”
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Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples by Takahashi, Shodai, Kagami, Yu, Hanaoka, Kenjiro, Terai, Takuya, Komatsu, Toru, Ueno, Tasuku, Uchiyama, Masanobu, Koyama-Honda, Ikuko, Mizushima, Noboru, Taguchi, Tomohiko, Arai, Hiroyuki, Nagano, Tetsuo, Urano, Yasuteru

“…In biological systems, the pH in intracellular organelles or tissues is strictly regulated, and differences of pH are deeply related to key biological events…”
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Development of Novel Dark Quenchers and Their Application to Imaging Probes by Hanaoka, Kenjiro

“…Rhodamine dyes are among the most widely used fluorescent dyes for bioimaging due to their high fluorescence quantum yield and high photostability. Recently,…”
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Development of a Highly Selective Fluorescence Probe for Hydrogen Sulfide by Sasakura, Kiyoshi, Hanaoka, Kenjiro, Shibuya, Norihiro, Mikami, Yoshinori, Kimura, Yuka, Komatsu, Toru, Ueno, Tasuku, Terai, Takuya, Kimura, Hideo, Nagano, Tetsuo

“…Hydrogen sulfide (H2S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe…”
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Rational Design of Highly Sensitive Fluorescence Probes for Protease and Glycosidase Based on Precisely Controlled Spirocyclization by Sakabe, Masayo, Asanuma, Daisuke, Kamiya, Mako, Iwatate, Ryu J, Hanaoka, Kenjiro, Terai, Takuya, Nagano, Tetsuo, Urano, Yasuteru

“…We have synthesized and evaluated a series of hydroxymethyl rhodamine derivatives and found an intriguing difference of intramolecular spirocyclization…”
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Development of Responsive Lanthanide-Based Magnetic Resonance Imaging and Luminescent Probes for Biological Applications by Hanaoka, Kenjiro

“…Lanthanide complexes have unique chemical characteristics compared with typical organic complexes, and have recently attracted much interest because of the…”
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Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide (NO) activate TRPA1 channels by Miyamoto, Ryo, Koike, Shin, Takano, Yoko, Shibuya, Norihiro, Kimura, Yuka, Hanaoka, Kenjiro, Urano, Yasuteru, Ogasawara, Yuki, Kimura, Hideo

“…Hydrogen sulfide (H 2 S) exerts synergistic effects with another gaseous signaling molecule nitric oxide (NO) on ion channels and vasculature. However, the…”
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Recent advances in probe design to detect reactive sulfur species and in the chemical reactions employed for fluorescence switching by Echizen, Honami, Hanaoka, Kenjiro

“…Reactive sulfur species, including hydrogen sulfide, hydropersulfide, and polysulfide, have many roles in biological systems. For example, hydrogen sulfide is…”
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Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor by Kitajima, Nami, Takikawa, Kenji, Sekiya, Hiroshi, Satoh, Kaname, Asanuma, Daisuke, Sakamoto, Hirokazu, Takahashi, Shodai, Hanaoka, Kenjiro, Urano, Yasuteru, Namiki, Shigeyuki, Iino, Masamitsu, Hirose, Kenzo

“…Adenosine 5' triphosphate (ATP) is a ubiquitous extracellular signaling messenger. Here, we describe a method for in-vivo imaging of extracellular ATP with…”
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Design and Synthesis of a Highly Sensitive Off-On Fluorescent Chemosensor for Zinc Ions Utilizing Internal Charge Transfer by Hanaoka, Kenjiro, Muramatsu, Yasuaki, Urano, Yasuteru, Terai, Takuya, Nagano, Tetsuo

“…Fluorescence imaging is a powerful tool for the visualization of biological molecules in living cells, tissue slices, and whole bodies, and is important for…”
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A Fluorescent Probe for Rapid, High‐Contrast Visualization of Folate‐Receptor‐Expressing Tumors In Vivo by Numasawa, Koji, Hanaoka, Kenjiro, Saito, Naoko, Yamaguchi, Yoshifumi, Ikeno, Takayuki, Echizen, Honami, Yasunaga, Masahiro, Komatsu, Toru, Ueno, Tasuku, Miura, Masayuki, Nagano, Tetsuo, Urano, Yasuteru

“…Folate receptors (FRs) are membrane proteins involved in folic acid uptake, and the alpha isoform (FR‐α) is overexpressed in ovarian and endometrial cancer…”
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Sulfide catabolism ameliorates hypoxic brain injury by Marutani, Eizo, Morita, Masanobu, Hirai, Shuichi, Kai, Shinichi, Grange, Robert M. H., Miyazaki, Yusuke, Nagashima, Fumiaki, Traeger, Lisa, Magliocca, Aurora, Ida, Tomoaki, Matsunaga, Tetsuro, Flicker, Daniel R., Corman, Benjamin, Mori, Naohiro, Yamazaki, Yumiko, Batten, Annabelle, Li, Rebecca, Tanaka, Tomohiro, Ikeda, Takamitsu, Nakagawa, Akito, Atochin, Dmitriy N., Ihara, Hideshi, Olenchock, Benjamin A., Shen, Xinggui, Nishida, Motohiro, Hanaoka, Kenjiro, Kevil, Christopher G., Xian, Ming, Bloch, Donald B., Akaike, Takaaki, Hindle, Allyson G., Motohashi, Hozumi, Ichinose, Fumito

“…The mammalian brain is highly vulnerable to oxygen deprivation, yet the mechanism underlying the brain’s sensitivity to hypoxia is incompletely understood…”
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Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT) by Sugimoto, Mizuki, Sasaki, Eita, Ohno, Hisashi, Ikeno, Takayuki, Yamada, Sota, Hanaoka, Kenjiro

“…Twisted intramolecular charge transfer (TICT) is a phenomenon involving intramolecular charge transfer together with intramolecular rotation upon…”
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A Water-Soluble Mechanochromic Luminescent Pyrene Derivative Exhibiting Recovery of the Initial Photoluminescence Color in a High-Humidity Environment by Sagara, Yoshimitsu, Komatsu, Toru, Ueno, Tasuku, Hanaoka, Kenjiro, Kato, Takashi, Nagano, Tetsuo

“…Switching of the luminescence properties of molecular materials in response to mechanical stimulation is of fundamental interest and also has a range of…”
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Design and Synthesis of an Activatable Photoacoustic Probe for Hypochlorous Acid by Ikeno, Takayuki, Hanaoka, Kenjiro, Iwaki, Shimpei, Myochin, Takuya, Murayama, Yoshiaki, Ohde, Hisashi, Komatsu, Toru, Ueno, Tasuku, Nagano, Tetsuo, Urano, Yasuteru

“…Photoacoustic (PA) imaging is a novel imaging modality that combines the high contrast of optical imaging and the deep tissue penetration of ultrasound. PA…”
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