Search Results - "Hanania, E G"

Results of MDR-1 Vector Modification Trial Indicate that Granulocyte/Macrophage Colony-Forming Unit Cells Do not Contribute to Posttransplant Hematopoietic Recovery Following Intensive Systemic Therapy by Hanania, E. G., Giles, R. E., Kavanagh, J., Ellerson, D., Zu, Z., Wang, T., Su, Y., Kudelka, A., Rahman, Z., Holmes, F., Hortobagyi, G., Claxton, D., Bachier, C., Thall, P., Cheng, S., Hester, J., Ostrove, J. M., Bird, R. E., Chang, A., Korbling, M., Seong, D., Cote, R., Holzmayer, T., Mechetner, E., Heimfeld, S., Berenson, R., Burtness, B., Edwards, C., Bast, R., Andreeff, M., Champlin, R., Deisseroth, A. B.

“…To formally test the hypothesis that the granulocyte/macrophage colony-forming unit (GM-CFU) cells can contribute to early hematopoietic reconstitution…”
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Real-time t(11;14) and t(14;18) PCR assays provide sensitive and quantitative assessments of minimal residual disease (MRD) by OLSSON, K, GERARD, C. J, ZEHNDER, J, JONES, C, RAMANATHAN, R, READING, C, HANANIA, E. G

“…Non-Hodgkin's lymphoma (NHL) arises as a clonal transformation of normal B and T cell differentiation and is often characterized by a higher incidence of…”
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Improved quantitation of minimal residual disease in multiple myeloma using real-time polymerase chain reaction and plasmid-DNA complementarity determining region III standards by GERARD, C. J, OLSSON, K, RAMANATHAN, R, READING, C, HANANIA, E. G

“…The complementarity determining region III of the rearranged immunoglobulin heavy chain gene has been the target for tumor-specific PCR assays for the…”
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Recent advances in the application of gene therapy to human disease by Hanania, E G, Kavanagh, J, Hortobagyi, G, Giles, R E, Champlin, R, Deisseroth, A B

“…To review the recent advances in the application of genetic modification strategies to the therapy of human diseases for which a molecular defect is known. A…”
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Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model by Hanania, E G, Deisseroth, A B

“…The administration of high and repeated doses of chemotherapy has been hampered by the bone marrow toxicity imposed by these drugs. This obstacle can be…”
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Resistance to taxol chemotherapy produced in mouse marrow cells by safety-modified retroviruses containing a human MDR-1 transcription unit by Hanania, E G, Fu, S, Roninson, I, Zu, Z, Deisseroth, A B

“…We used an animal model system to transplant lethally-irradiated mice with one million marrow cells which had been: (1) collected from 5-fluorouracil (5-FU)…”
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Addition of the human interferon beta scaffold attachment region to retroviral vector backbones increases the level of in vivo transgene expression among progeny of engrafted human hematopoietic stem cells by Murray, L, Travis, M, Luens-Abitorabi, K, Olsson, K, Plavec, I, Forestell, S, Hanania, E G, Hill, B

“…Absence of durable high-level expression of transgenes from Moloney murine leukemia (Mo-MuLV) retroviral vectors has been a hurdle in bringing effective gene…”
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Simultaneous genetic chemoprotection of normal marrow cells and genetic chemosensitization of breast cancer cells in a mouse cancer gene therapy model by HANANIA, E. G, DEISSEROTH, A. B

“…Repeated exposures to high doses of chemotherapy are often required to eradicate solid tumors. The success of such high-dose therapy is often limited by the…”
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Chemotherapy resistance to taxol in clonogenic progenitor cells following transduction of CD34 selected marrow and peripheral blood cells with a retrovirus that contains the MDR-1 chemotherapy resistance gene by Hanania, E G, Fu, S, Zu, Z, Hegewisch-Becker, S, Korbling, M, Hester, J, Durett, A, Andreeff, M, Mechetner, E, Holzmayer, T

“…A retrovirus containing the multiple drug resistance (MDR-1) cDNA, was used to transduce cultures of CD34 selected human marrow cells, on stromal monolayers in…”
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Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML by Deisseroth, A B, Zu, Z, Claxton, D, Hanania, E G, Fu, S, Ellerson, D, Goldberg, L, Thomas, M, Janicek, K, Anderson, W F

“…Relapse after autologous bone marrow transplantation for chronic myelogenous leukemia (CML) can be due either to the persistence of leukemia cells in systemic…”
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Regulation of retinoblastoma gene expression in a mouse mammary tumor model by Hanania, E G, Au, W W, Ullrich, R L, Papaconstantinou, J

“…We initiated studies to investigate the involvement of the murine retinoblastoma (RB) gene in mammary carcinogenesis using cell lines derived from mammary…”
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Suppression of tumorigenesis by transcription units expressing the antisense E6 and E7 messenger RNA (mRNA) for the transforming proteins of the human papilloma virus and the sense mRNA for the retinoblastoma gene in cervical carcinoma cells by Hu, G, Liu, W, Hanania, E G, Fu, S, Wang, T, Deisseroth, A B

“…Human cervical carcinoma cell lines that harbor human papilloma virus (HPV) have been reported to express HPV E6 and E7 proteins at least in the beginning…”
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Transduction of MDR1 into human and mouse haemopoietic progenitor cells: use of rhodamine (Rh123) to determine transduction frequency and in vivo selection by Hegewisch-Becker, S, Hanania, E G, Fu, S, Körbling, M, Deisseroth, A B, Andreeff, M

“…The MDR1 gene product P-glycoprotein (P-gp) extrudes several anticancer drugs including taxol and fluorescent dyes such as rhodamine (Rh123). Modulation of the…”
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PML/RARalpha, a fusion protein in acute promyelocytic leukemia, prevents growth factor withdrawal-induced apoptosis in TF-1 cells by Fu, S, Consoli, U, Hanania, E G, Zu, Z, Claxton, D F, Andreeff, M, Deisseroth, A B

“…A unique mRNA produced by the t(15;17) (q22-24;q11-21) translocation in the leukemic cells of acute promyelocytic leukemia patients encodes a chimeric protein,…”
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Hematopoietic Retroviral Gene Marking in Patients with Follicular Non-Hodgkin's Lymphoma by Bachier, Carlos R., Giles, Richard E., Ellerson, Deborah, Hanania, Ellie G., Garcia-Sanchez, Felix, Andreeff, Michael, Cabanillas, Fernando, Champlin, Richard, Choudhury, Raja, Berenson, Ronald, Heimfeld, Shelly, Deisseroth, Albert B.

“…We conducted a double retroviral vector (RV) gene marking trial to test for the possible contribution to relapse of follicular non-Hodgkin's lymphoma (FNHL)…”
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PML/RARα, a fusion protein in acute promyelocytic leukemia, prevents growth factor withdrawal-induced apoptosis in TF-1 cells by FU, S, CONSOLI, U, HANANIA, E. G, ZU, Z, CLAXTON, D. F, ANDREEFF, M, DEISSEROTH, A. B

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Genetic therapy using bone marrow transplantation by Giles, R E, Hanania, E G, Fu, S, Deisseroth, A

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Molecular approaches to the diagnosis and treatment of cancer by Deisseroth, A B, Kantarjian, H, Talpaz, M, Champlin, R, Reading, C, Hanania, E G, Fu, S, Randhawa, G S, Cha, Y, Fang, X

“…We have used autologous bone marrow transplantation (ABMT) as a setting to develop the genetic therapy of cancer in hematopoietic neoplasms based on the use of…”
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Optoinjection for efficient targeted delivery of a broad range of compounds and macromolecules into diverse cell types by Clark, Imran B, Hanania, Elie G, Stevens, Janine, Gallina, Marijo, Fieck, Annabeth, Brandes, Rolf, Palsson, Bernhard O, Koller, Manfred R

“…Efficient delivery of compounds and macromolecules into living cells is essential in many fields including basic research, applied drug discovery, and clinical…”
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High‐throughput laser‐mediated in situ cell purification with high purity and yield by Koller, Manfred R., Hanania, Elie G., Stevens, Janine, Eisfeld, Timothy M., Sasaki, Glenn C., Fieck, Annabeth, Palsson, Bernhard Ø.

“…Background Technologies for purification of living cells have significantly advanced basic and applied research in many settings. Nevertheless, certain…”
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