Search Results - "Hanage, WP"

Invasiveness of Serotypes and Clones of Streptococcus pneumoniae among Children in Finland by Hanage, William P, Kaijalainen, Tarja H, Syrjänen, Ritva K, Auranen, Kari, Leinonen, Maija, Mäkelä, P. Helena, Spratt, Brian G

“…Streptococcus pneumoniae (the pneumococcus) causes diseases from otitis media to life-threatening invasive infection. The species is extremely antigenically…”
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Evolution via recombination: Cell-to-cell contact facilitates larger recombination events in Streptococcus pneumoniae by Cowley, Lauren A, Petersen, Fernanda C, Junges, Roger, Jimson D Jimenez, Med, Morrison, Donald A, Hanage, William P

“…Homologous recombination in the genetic transformation model organism Streptococcus pneumoniae is thought to be important in the adaptation and evolution of…”
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eBURST: Inferring Patterns of Evolutionary Descent among Clusters of Related Bacterial Genotypes from Multilocus Sequence Typing Data by FELL, Edward J, LI, Bao C, AANENSEN, David M, HANAGE, William P, SPRATT, Brian G

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Fuzzy species among recombinogenic bacteria by Hanage, William P, Fraser, Christophe, Spratt, Brian G

“…It is a matter of ongoing debate whether a universal species concept is possible for bacteria. Indeed, it is not clear whether closely related isolates of…”
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Neutral Microepidemic Evolution of Bacterial Pathogens by Fraser, Christophe, Hanage, William P., Spratt, Brian G., Mekalanos, John J.

“…Understanding bacterial population genetics is vital for interpreting the response of bacterial populations to selection pressures such as antibiotic treatment…”
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Pneumococcal protein antigen serology varies with age and may predict antigenic profile of colonizing isolates by Azarian, T, Grant, LR, Georgieva, M, Hammitt, LL, Reid, R, Bentley, SD, Goldblatt, D, Santosham, M, Weatherholtz, R, Burbidge, P, Goklish, N, Thompson, CM, Hanage, WP, O’Brien, KL, Lipsitch, M

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Displaying the relatedness among isolates of bacterial species – the eBURST approach by Spratt, Brian G., Hanage, William P., Li, Bao, Aanensen, David M., Feil, Edward J.

“…Determining the most appropriate way to represent the relationships between bacterial isolates is complicated by the differing rates of recombination within…”
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The impact of homologous recombination on the generation of diversity in bacteria by Hanage, William P., Fraser, Christophe, Spratt, Brian G.

“…The imprint of demographic and selective processes on bacterial population structure needs to be evaluated as deviation from the expectations of an appropriate…”
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Streptococcus pneumoniae Contains 3 rlrA Pilus Variants That Are Clonally Related by Moschioni, Monica, Donati, Claudio, Muzzi, Alessandro, Masignani, Vega, Censini, Stefano, Hanage, William P., Bishop, Cynthia J., Reis, Joice Neves, Normark, Staffan, Henriques-Normark, Birgitta, Covacci, Antonello, Rappuoli, Rino, Barocchi, Michèle A.

“…BackgroundPilus components of Streptococcus pneumoniae encoded by rlrA were recently shown to elicit protection in an animal model of infection. Limited data…”
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Using Multilocus Sequence Data To Define the Pneumococcus by HANAGE, William P, KAIJALAINEN, Tarja, HERVA, Elja, SAUKKORIIPI, Annika, SYRJÄNEN, Ritva, SPRATT, Brian G

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Modelling infectious disease — time to think outside the box? by Wiles, Siouxsie, Hanage, William P, Frankel, Gad, Robertson, Brian

“…Models occupy an essential position in the study of infectious disease as a result of the ethical problems of exposing humans to potentially lethal agents…”
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The relative contributions of recombination and point mutation to the diversification of bacterial clones by Spratt, Brian G, Hanage, William P, Feil, Edward J

“…Low levels of recombination in bacterial species have often been inferred from the presence of linkage disequilibrium between the alleles at different loci in…”
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A Successful, Diverse Disease-Associated Lineage of Nontypeable Pneumococci That Has Lost the Capsular Biosynthesis Locus by HANAGE, W. P, KAIJALAINEN, T, SAUKKORIIPI, A, RICKCORD, J. L, SPRATT, B. G

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Clonal replacement among 19AStreptococcus pneumoniaein Massachusetts, prior to 13 valent conjugate vaccination by Hanage, WP, Bishop, CJ, Lee, GM, Lipsitch, M, Stevenson, A, Rifas-Shiman, SL, Pelton, SI, Huang, SS, Finkelstein, JA

“…Highlights * Long-term ongoing study of PCV-7 impact on pneumococcal population structure using MLST. * Multiply resistant 19A clone ST 320 replacing…”
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Ability of Pneumococcal Serotypes and Clones To Cause Acute Otitis Media: Implications for the Prevention of Otitis Media by Conjugate Vaccines by HANAGE, William P, AURANEN, Kari, SYRJÄNEN, Ritva, HERVA, Elja, MÄKELÄ, P. Helena, KILPI, Terhi, SPRATT, Brian G

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Stimulation of Cytokine Release and Adhesion Molecule Expression by Products of Viridans Streptococci by Hanage, W. P., Cohen, J.

“…The viridans streptococci (VS) are associated with the development of a rapidly fulminant shock syndrome in neutropenic patients. A panel of 52 VS strains…”
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