Effectiveness of the critical congenital heart disease screening program for early diagnosis of cardiac abnormalities in newborn infants

Effectiveness of the critical congenital heart disease screening program for early diagnosis of cardiac abnormalities in newborn infants

To evaluate the effectiveness of critical congenital heart disease (CCHD) screening program for early diagnosis of cardiac anomalies in newborn infants.  Methods: This is a hospital-based prospective cross-sectional study conducted in the Pediatric and Neonatology Department, King Fahad Hospital at ...

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Bibliographic Details
Published in:Saudi medical journal Vol. 38; no. 10; pp. 1019 - 1024
Main Authors: Almawazini, Abdulmajid M, Hanafi, Hamdi K, Madkhali, Hasan A, Majrashi, Noura B
Format: Journal Article
Language:English
Published: Saudi Arabia Saudi Medical Journal 01-10-2017
Prince Sultan Military Medical City (PSMMC)
Subjects:
Analysis
Cardiovascular disease
Congenital heart defects
Health aspects
Health screening
Medical diagnosis
Medical screening
Newborn babies
Newborn infants
Original
Pediatrics
Saudi Arabia
Poland
Sweden
United States > US
Norway
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Summary:To evaluate the effectiveness of critical congenital heart disease (CCHD) screening program for early diagnosis of cardiac anomalies in newborn infants.  Methods: This is a hospital-based prospective cross-sectional study conducted in the Pediatric and Neonatology Department, King Fahad Hospital at  Albaha, Saudi Arabia, between February 2016 and February 2017. Results: We screened 2961 (95.4%) of 3103 patients in a nursery unit; 142 (4.6%) patients were not screened. The test was positive in 114 (3.9%) patients and negative in 2847 (96.1%). There were 94 (3.2%) false positives and 20 (0.7%) true positives. Critical cardiac defects were diagnosed in 7 (0.2%) patients of all screened infants, and severe pulmonary hypertension was diagnosed in 13 (0.4%) patients. True negative results were found in 2841(96%) patients, and no cardiac defect was diagnosed, whereas false negative results were seen in 6 (0.2%) patients diagnosed with ventricular septal defect. The sensitivity was 77%, and the specificity was very high at 97%, with a positive predictive value of 18%, and a negative predictive value of 99.8% (95% confidence interval 13.78-19.18, p=0.0001). Conclusion: Pulse oximetry was found to be easy, safe, sensitive, and highly specific for diagnosis of CCHD.
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ISSN:0379-5284
1658-3175
DOI:10.15537/smj.2017.10.20295