Therapeutic potency of A1 adenosine receptor antagonists in the treatment of cardiovascular diseases, current status and perspectives

Therapeutic potency of A1 adenosine receptor antagonists in the treatment of cardiovascular diseases, current status and perspectives

Background Cardiomyocytes form, transport, and metabolize the omnipresent metabolite adenosine. Depending upon the adenosine concentrations and the pharmacological properties of receptor subtypes, adenosine exerts (patho)physiological responses in the cardiovascular system. The objective of this rev...

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Published in:Molecular biology reports Vol. 51; no. 1; p. 358
Main Authors: Bahreyni, Amirhossein, Saeedi, Nikoo, Al-Asady, Abdulridha Mohammed, Soleimani, Atena, Ghorbani, Elnaz, Khazaei, Majid, Alaei, Maryam, Hanaei, Reyhane, Ryzhikov, Mikhail, Avan, Amir, Hassanian, Seyed Mahdi
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-12-2024
Springer Nature B.V
Subjects:
Adenosine
Animal Anatomy
Animal Biochemistry
Biochemistry
Biomedical and Life Sciences
Blood pressure
Cardiac arrhythmia
Cardiomyocytes
Cardiovascular disease
Cardiovascular diseases
Cardiovascular system
Drug dosages
Fatty acids
Heart rate
Histology
Hypotension
Kinases
Life Sciences
Lipolysis
Medicine
Metabolism
Metabolites
Mini Review
Molecular biology
Morphology
Physiology
Proteins
Risk factors
Toxicity
A1 adenosine receptor
Cardiovascular diseases
Pharmacological inhibitors
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Summary:Background Cardiomyocytes form, transport, and metabolize the omnipresent metabolite adenosine. Depending upon the adenosine concentrations and the pharmacological properties of receptor subtypes, adenosine exerts (patho)physiological responses in the cardiovascular system. The objective of this review is to present different protective mechanisms of A1-adenosine receptor inhibitors in cardiovascular diseases. Methods and results Literature references were collected and sorted using relevant keywords and key phrases as search terms in scientific databases such as Web of Science, PubMed and Google Scholar. A1 adenosine receptor regulates free fatty acid metabolism, lipolysis, heart rate, blood pressure, and cardiovascular toxicity. The evidence clearly supporting the therapeutic potency of pharmacological A1 adenosine receptors agonists and antagonists in modulating cardiovascular risk factor parameters and treatment of cardiovascular diseases. Conclusion This review summarizes the protective role of pharmacological A1-adenosine receptor regulators in the pathogenesis of cardiovascular diseases for a better management of cardiovascular diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-024-09246-6