Search Results - "Hanada, Toshikatsu"

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses by Lu, Li-Fan, Boldin, Mark P., Chaudhry, Ashutosh, Lin, Ling-Li, Taganov, Konstantin D., Hanada, Toshikatsu, Yoshimura, Akihiko, Baltimore, David, Rudensky, Alexander Y.

“…Foxp3 + regulatory T (Treg) cells maintain immune homeostasis by limiting different types of inflammatory responses. Here, we report that miR-146a, one of the…”
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Zebrafish as a Useful Model System for Human Liver Disease by Shimizu, Nobuyuki, Shiraishi, Hiroshi, Hanada, Toshikatsu

“…Liver diseases represent a significant global health challenge, thereby necessitating extensive research to understand their intricate complexities and to…”
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Ankle2 deficiency-associated microcephaly and spermatogenesis defects in zebrafish are alleviated by heterozygous deletion of vrk1 by Apridita Sebastian, Wulan, Shiraishi, Hiroshi, Shimizu, Nobuyuki, Umeda, Ryohei, Lai, Shaohong, Ikeuchi, Mayo, Morisaki, Ikuko, Yano, Shinji, Yoshimura, Akihiko, Hanada, Reiko, Hanada, Toshikatsu

“…Autosomal recessive primary microcephaly (MCPH) is a rare congenital disorder characterized by a below average brain volume at birth and is associated with…”
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Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor by Amada, Kohei, Hijiya, Naoki, Ikarimoto, Sawa, Yanagihara, Kazuyoshi, Hanada, Toshikatsu, Hidano, Shinya, Kurogi, Shusaku, Tsukamoto, Yoshiyuki, Nakada, Chisato, Kinoshita, Keisuke, Hirashita, Yuka, Uchida, Tomohisa, Shin, Toshitaka, Yada, Kazuhiro, Hirashita, Teijiro, Kobayashi, Takashi, Murakami, Kazunari, Inomata, Masafumi, Shirao, Kuniaki, Aoki, Masahiro, Takekawa, Mutsuhiro, Moriyama, Masatsugu

“…Constitutive activation of the mitogen‐activated protein kinase (MAPK) signaling pathway is essential for tumorigenesis of pancreatic ductal adenocarcinoma…”
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Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish by Inoue, Masanori, Miyahara, Hiroaki, Shiraishi, Hiroshi, Shimizu, Nobuyuki, Tsumori, Mika, Kiyota, Kyoko, Maeda, Miwako, Umeda, Ryohei, Ishitani, Tohru, Hanada, Reiko, Ihara, Kenji, Hanada, Toshikatsu

“…Leucyl-tRNA synthetase (LARS) is an enzyme that catalyses the ligation of leucine with leucine tRNA. LARS is also essential to sensitize the intracellular…”
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Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function by Karaca, Ender, Weitzer, Stefan, Pehlivan, Davut, Shiraishi, Hiroshi, Gogakos, Tasos, Hanada, Toshikatsu, Jhangiani, Shalini N., Wiszniewski, Wojciech, Withers, Marjorie, Campbell, Ian M., Erdin, Serkan, Isikay, Sedat, Franco, Luis M., Gonzaga-Jauregui, Claudia, Gambin, Tomasz, Gelowani, Violet, Hunter, Jill V., Yesil, Gozde, Koparir, Erkan, Yilmaz, Sarenur, Brown, Miguel, Briskin, Daniel, Hafner, Markus, Morozov, Pavel, Farazi, Thalia A., Bernreuther, Christian, Glatzel, Markus, Trattnig, Siegfried, Friske, Joachim, Kronnerwetter, Claudia, Bainbridge, Matthew N., Gezdirici, Alper, Seven, Mehmet, Muzny, Donna M., Boerwinkle, Eric, Ozen, Mustafa, Clausen, Tim, Tuschl, Thomas, Yuksel, Adnan, Hess, Andreas, Gibbs, Richard A., Martinez, Javier, Penninger, Josef M., Lupski, James R.

“…CLP1 is a RNA kinase involved in tRNA splicing. Recently, CLP1 kinase-dead mice were shown to display a neuromuscular disorder with loss of motor neurons and…”
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AIF-regulated oxidative phosphorylation supports lung cancer development by Rao, Shuan, Mondragón, Laura, Pranjic, Blanka, Hanada, Toshikatsu, Stoll, Gautier, Köcher, Thomas, Zhang, Peng, Jais, Alexander, Lercher, Alexander, Bergthaler, Andreas, Schramek, Daniel, Haigh, Katharina, Sica, Valentina, Leduc, Marion, Modjtahedi, Nazanine, Pai, Tsung-Pin, Onji, Masahiro, Uribesalgo, Iris, Hanada, Reiko, Kozieradzki, Ivona, Koglgruber, Rubina, Cronin, Shane J., She, Zhigang, Quehenberger, Franz, Popper, Helmut, Kenner, Lukas, Haigh, Jody J., Kepp, Oliver, Rak, Malgorzata, Cai, Kaican, Kroemer, Guido, Penninger, Josef M.

“…Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue…”
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Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease by Tokumaru, Tomoko, Apolinario, Magdeline E. Carrasco, Shimizu, Nobuyuki, Umeda, Ryohei, Honda, Koichi, Shikano, Kenshiro, Teranishi, Hitoshi, Hikida, Takatoshi, Hanada, Toshikatsu, Ohta, Keisuke, Li, Yulong, Murakami, Kazunari, Hanada, Reiko

“…Steatotic liver disease (SLD) is a burgeoning health problem predominantly associated with excessive alcohol consumption, which causes alcohol-related liver…”
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Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10 by Morisaki, Ikuko, Shiraishi, Hiroshi, Fujinami, Hiroyuki, Shimizu, Nobuyuki, Hikida, Takatoshi, Arai, Yuji, Kobayashi, Takashi, Hanada, Reiko, Penninger, Josef M., Fujiki, Minoru, Hanada, Toshikatsu

“…Cleavage factor polyribonucleotide kinase subunit 1 (CLP1), an RNA kinase, plays essential roles in protein complexes involved in the 3′-end formation and…”
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Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy by Inoue, Masanori, Sebastian, Wulan Apridita, Sonoda, Shota, Miyahara, Hiroaki, Shimizu, Nobuyuki, Shiraishi, Hiroshi, Maeda, Miwako, Yanagi, Kumiko, Kaname, Tadashi, Hanada, Reiko, Hanada, Toshikatsu, Ihara, Kenji

“…Biallelic pathogenic variants of LARS1 cause infantile liver failure syndrome type 1 (ILFS1), which is characterized by acute hepatic failure with steatosis in…”
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Metabolome Characteristics of Liver Autophagy Deficiency under Starvation Conditions in Infancy by Sekiguchi, Kazuhito, Miyahara, Hiroaki, Inoue, Masanori, Kiyota, Kyoko, Sakai, Kumiko, Hanada, Toshikatsu, Ihara, Kenji

“…The liver function is essential for metabolism, detoxification, and bile synthesis, even in the neonatal period. Autophagy plays significance roles in THE…”
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Vrk2 deficiency elicits aggressive behavior in female zebrafish by Umeda, Ryohei, Teranishi, Hitoshi, Hada, Kazumasa, Shimizu, Nobuyuki, Shiraishi, Hiroshi, Urushibata, Hirotaro, Lai, Shaohong, Shide, Masahito, Carrasco Apolinario, Magdeline E., Higa, Ryoko, Shikano, Kenshiro, Shin, Toshitaka, Mimata, Hiromitsu, Hikida, Takatoshi, Hanada, Toshikatsu, Hanada, Reiko

“…Vaccinia‐related kinase 2 (VRK2) is a serine/threonine kinase initially identified in highly proliferative cells such as thymocytes and fetal liver cells, and…”
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Central control of fever and female body temperature by RANKL/RANK by Ueta, Yoichi, Klaere, Steffen, Hanada, Reiko, Leibbrandt, Andreas, Bader, Michael, Trichereau, Jean, Paolino, Magdalena, Penninger, Josef M, Hanada, Toshikatsu, Kilic, Sara Sebnem, Pifl, Christian, Furuyashiki, Tomoyuki, Qadri, Fatimunnisa, von Haeseler, Arndt, Plehm, Ralph, Komnenovic, Vukoslav, Narumiya, Shuh, Fujihara, Hiroaki, Takahashi, Naoyuki, Kitaoka, Shiho, Mimata, Hiromitsu, Yoshimatsu, Hironobu

“…Receptor-activator of NF-κB ligand (TNFSF11, also known as RANKL, OPGL, TRANCE and ODF) and its tumour necrosis factor (TNF)-family receptor RANK are essential…”
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Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity by Yoshimura, Akihiko, Mori, Hiroyuki, Hanada, Reiko, Hanada, Toshikatsu, Aki, Daisuke, Mashima, Ryuichi, Nishinakamura, Hitomi, Torisu, Takehiro, Chien, Kenneth R, Yasukawa, Hideo

“…Leptin is an adipocyte-derived hormone that plays a key role in energy homeostasis, yet resistance to leptin is a feature of most cases of obesity in humans…”
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CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders by Weitzer, Stefan, Hanada, Toshikatsu, Penninger, Josef M., Martinez, Javier

“…Defects in RNA metabolic pathways are well‐established causes for neurodegenerative disorders. Several mutations in genes involved in pre‐messenger RNA…”
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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages by Yoshimura, Akihiko, Yasukawa, Hideo, Ohishi, Masanobu, Mori, Hiroyuki, Murakami, Masaaki, Chinen, Takatoshi, Aki, Daisuke, Hanada, Toshikatsu, Takeda, Kiyoshi, Akira, Shizuo, Hoshijima, Masahiko, Hirano, Toshio, Chien, Kenneth R

“…Whereas interleukin-6 (IL-6) is a proinflammatory cytokine, IL-10 is an anti-inflammatory cytokine. Although signal transducer and activator of transcription 3…”
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Physiology and pathophysiology of the RANKL/RANK system by Hanada, Reiko, Hanada, Toshikatsu, Penninger, Josef M

“…The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during…”
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Negative regulation of cytokine signaling and immune responses by SOCS proteins by Yoshimura, Akihiko, Nishinakamura, Hitomi, Matsumura, Yumiko, Hanada, Toshikatsu

“…Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological…”
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CD105 maintains the thermogenic program of beige adipocytes by regulating Smad2 signaling by Higa, Ryoko, Hanada, Toshikatsu, Teranishi, Hitoshi, Miki, Daisuke, Seo, Kazuyuki, Hada, Kazumasa, Shiraishi, Hiroshi, Mimata, Hiromitsu, Hanada, Reiko, Kangawa, Kenji, Murai, Toshiya, Nakao, Kazuwa

“…Beige adipocytes are thermogenic adipocytes with developmental and anatomical properties distinct from those of classical brown adipocytes. Recent studies have…”
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Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice by Teranishi, Hitoshi, Hayashi, Masafumi, Higa, Ryoko, Mori, Kenji, Miyazawa, Takashi, Hino, Jun, Amano, Yuichiro, Tozawa, Ryuichi, Ida, Takanori, Hanada, Toshikatsu, Miyazato, Mikiya, Hanada, Reiko, Kangawa, Kenji, Nakao, Kazuwa

“…•Neuromedin U (NMU) and NMU receptor 1 (NMUR1) are undetectable in normal liver.•In NASH, NMU and NMUR1 production is increased with inflammation.•Hepatic NMU…”
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