Dextromethorphan protects male but not female mice with brain ischemia

Dextromethorphan protects male but not female mice with brain ischemia

The non-competitive N-methyl-D-aspartate receptor antagonist dextromethorphan is protective against some types of brain injury. Unilateral carotid ligation in postnatal day 12 CD1 mice produces ischemic brain injury. To evaluate the neuroprotective potential of dextromethorphan against ischemic inju...

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Bibliographic Details
Published in:Neuroreport Vol. 17; no. 12; pp. 1319 - 1322
Main Authors: Comi, Anne M, Highet, Bridget H, Mehta, Paulomi, Hana Chong, Tae, Johnston, Michael V, Ann Wilson, Mary
Format: Journal Article
Language:English
Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 21-08-2006
Lippincott Williams and Wilkins
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Brain Ischemia - prevention & control
Dextromethorphan - therapeutic use
Disease Models, Animal
Female
Male
Medical sciences
Mice
Neurology
Neuroprotective Agents - therapeutic use
Severity of Illness Index
Sex Factors
Vascular diseases and vascular malformations of the nervous system
Neuroprotection
Nervous system diseases
Rodentia
Sex
Cardiovascular disease
Male
Glutamate receptor
Dextromethorphan
Cerebral disorder
ischemia
Vascular disease
carotid ligation
Vertebrata
Mammalia
Mouse
immature mouse
Newborn animal
Central nervous system disease
Brain ischemia
N-methyl-D-aspartate receptor
sex-related neuroprotection
Female
NMDA receptor
Cerebrovascular disease
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Summary:The non-competitive N-methyl-D-aspartate receptor antagonist dextromethorphan is protective against some types of brain injury. Unilateral carotid ligation in postnatal day 12 CD1 mice produces ischemic brain injury. To evaluate the neuroprotective potential of dextromethorphan against ischemic injury in the immature brain, seven litters of postnatal day 12 CD1 mice received either dextromethorphan or vehicle after a unilateral carotid ligation. Only the male pups were protected, and brain injury was unchanged in the female pups treated with dextromethorphan. These results suggest that dextromethorphan neuroprotection against ischemic injury in the immature brain is sex-dependent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0959-4965
1473-558X
DOI:10.1097/01.wnr.0000220136.98918.41