Search Results - "Han, R. Z."

Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition by Reich, Siegfried H, Sprengeler, Paul A, Chiang, Gary G, Appleman, James R, Chen, Joan, Clarine, Jeff, Eam, Boreth, Ernst, Justin T, Han, Qing, Goel, Vikas K, Han, Edward Z. R, Huang, Vera, Hung, Ivy N. J, Jemison, Adrianna, Jessen, Katti A, Molter, Jolene, Murphy, Douglas, Neal, Melissa, Parker, Gregory S, Shaghafi, Michael, Sperry, Samuel, Staunton, Jocelyn, Stumpf, Craig R, Thompson, Peggy A, Tran, Chinh, Webber, Stephen E, Wegerski, Christopher J, Zheng, Hong, Webster, Kevin R

“…Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)­1/2 are key regulators of mRNA…”
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Numerical simulation and experiment study on hollow spinning process for square cross-section cone by Jia, Z., Han, Z. R., Xu, Q., Peng, W. F.

“…Spinning process is investigated to reveal the mechanism of square cross-section spinning without mandrel. The finite element model with the roller path…”
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Very low prevalence of asthma and allergies in schoolchildren from rural Beijing, China by Ma, Yu, Zhao, Jing, Han, Z.R., Chen, Yuzhi, Leung, Ting F., Wong, Gary W.K.

“…Background The prevalence of asthma is relatively low in the Chinese population. There is consistent evidence that growing up on a farm is associated with…”
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Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers by Croucher, David R, Iconomou, Mary, Hastings, Jordan F, Kennedy, Sean P, Han, Jeremy Z R, Shearer, Robert F, McKenna, Jessie, Wan, Adrian, Lau, Joseph, Aparicio, Samuel, Saunders, Darren N

“…The dynamic assembly of multiprotein complexes is a central mechanism of many cell signaling pathways. This process is key to maintaining the spatiotemporal…”
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Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer by Kennedy, Sean P, Han, Jeremy Z R, Portman, Neil, Nobis, Max, Hastings, Jordan F, Murphy, Kendelle J, Latham, Sharissa L, Cadell, Antonia L, Miladinovic, Dushan, Marriott, Gabriella R, O'Donnell, Yolande E I, Shearer, Robert F, Williams, James T, Munoz, Amaya Garcia, Cox, Thomas R, Watkins, D Neil, Saunders, Darren N, Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David R

“…The oncogenic receptor tyrosine kinase (RTK) ERBB2 is known to dimerize with other EGFR family members, particularly ERBB3, through which it potently activates…”
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A zebrafish functional genomics model to investigate the role of human A20 variants in vivo by Cultrone, Daniele, Zammit, Nathan W., Self, Eleanor, Postert, Benno, Han, Jeremy Z. R., Bailey, Jacqueline, Warren, Joanna, Croucher, David R., Kikuchi, Kazu, Bogdanovic, Ozren, Chtanova, Tatyana, Hesselson, Daniel, Grey, Shane T.

“…Germline loss-of-function variation in TNFAIP3 , encoding A20, has been implicated in a wide variety of autoinflammatory and autoimmune conditions, with…”
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Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma by Phimmachanh, Monica, Han, Jeremy Z. R., O’Donnell, Yolande E. I., Latham, Sharissa L., Croucher, David R.

“…Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone…”
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Study on die-less spinning of square section cone with fillets by Jia, Z., Fan, Z. J., Han, Z. R.

“…Due to the high flexibility and low cost, die-less spinning has great potential in aviation, aerospace, agricultural machinery, and lighting manufacturing…”
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Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma by Hastings, Jordan F, Gonzalez Rajal, Alvaro, Latham, Sharissa L, Han, Jeremy Zr, McCloy, Rachael A, O'Donnell, Yolande Ei, Phimmachanh, Monica, Murphy, Alexander D, Nagrial, Adnan, Daneshvar, Dariush, Chin, Venessa, Watkins, D Neil, Burgess, Andrew, Croucher, David R

“…The identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has previously been hampered by…”
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A research on thickness distribution of oblique cone in dieless shear spinning by Han, Z. R., Fan, Z. J., Xiao, Y., Jia, Z.

“…In order to shorten the preparation period, dieless shear spinning is widely used in various industrial fields with advantage of economy of materials and easy…”
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Parental Support for Autonomy and Child Depressive Symptoms in Middle Childhood: The Mediating Role of Parent–Child Attachment by Yan, J., Han, Z. R., Tang, Y., Zhang, X.

“…To facilitate understanding of the factors associated with child depressive symptoms in middle childhood, we examined the roles of parental support for…”
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The constant temperature control system of multi-pass and die-less shear spinning by flame heating by Han, Z. R., Fan, Z. J., Xiao, Y., Jia, Z.

“…In order to improve the formability of challenging materials, the innovative flame-heating integration into a spinning machine is proposed to apply new…”
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Numerical simulation and experimental study on the non-axisymmetric die-less shear spinning by Jia, Z., Han, Z. R., Liu, B. M., Fan, Z. J.

“…The non-axisymmetric cone has broad application prospects and is feasible to be manufactured via die-less shear spinning process which however lacks of…”
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Experimental study on wrinkle suppressing in multi-pass drawing spinning of 304 stainless steel cylinder by Jia, Z., Li, L., Han, Z. R., Fan, Z. J., Liu, B. M.

“…Cylinder shell parts are widely used in industrial and civil areas, and 304 stainless steel cylinders were attempted to be formed by multi-pass drawing…”
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Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma by Hastings, Jordan F, Latham, Sharissa L, Kamili, Alvin, Wheatley, Madeleine S, Han, Jeremy Z R, Wong-Erasmus, Marie, Phimmachanh, Monica, Nobis, Max, Pantarelli, Chiara, Cadell, Antonia L, O'Donnell, Yolande E I, Leong, King Ho, Lynn, Sophie, Geng, Fan-Suo, Cui, Lujing, Yan, Sabrina, Achinger-Kawecka, Joanna, Stirzaker, Clare, Norris, Murray D, Haber, Michelle, Trahair, Toby N, Speleman, Frank, De Preter, Katleen, Cowley, Mark J, Bogdanovic, Ozren, Timpson, Paul, Cox, Thomas R, Kolch, Walter, Fletcher, Jamie I, Fey, Dirk, Croucher, David R

“…Gene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare cancer cells. However, we now…”
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Effects of processing parameters on the surface quality of square section die-less spinning by Jia, Z., Han, Z. R., Xu, Q., Peng, W. F., Kong, Q. M.

“…In view of the importance of the surface quality in the application to the square section die-less spinning, the effects of several key parameters which…”
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Novel Weight Mapping Method for Reliable NVM based Neural Network by Han, L.X., Xiang, Y.C., Huang, P., Yu, G. H., Han, R. Z., Liu, X. Y., Kang, J. F.

“…Errors of vector-matrix-multiplication induced by interconnect resistance become a crucial reliability challenge in non-volatile memory (NVM) based neural…”
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Study on the behavior of magnesium in molten salt electrolysis in-situ desulfurization during hot metal pretreatment by L. Cheng, K. Liu, R. Z. Han, N. Luo

“…A desulfurization method based molten salt electrochemistry using magnesite-based desulfurizer for hot metal pretreatment was investigated. The feasibility of…”
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Prediction of phosphorylation sites based on the integration of multiple classifiers by Han, R Z, Wang, D, Chen, Y H, Dong, L K, Fan, Y L

“…Phosphorylation is an important part of post-translational modifications of proteins, and is essential for many biological activities. Phosphorylation and…”
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The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family by Kennedy, Sean P, Hastings, Jordan F, Han, Jeremy Z R, Croucher, David R

“…Each member of the epidermal growth factor receptor (EGFR) family plays a key role in normal development, homeostasis, and a variety of pathophysiological…”
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