Search Results - "Han, Kevin Tianxiang"

Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers by Han, Tianxiang Kevin, Proctor, William R, Costales, Chester L, Cai, Hao, Everett, Ruth S, Thakker, Dhiren R

“…Metformin is the frontline therapy for type II diabetes mellitus. The oral bioavailability of metformin is unexpectedly high, between 40 and 60%, given its…”
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Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes by Han, Tianxiang Kevin, Everett, Ruth S, Proctor, William R, Ng, Chee M, Costales, Chester L, Brouwer, Kim L R, Thakker, Dhiren R

“…Organic cation transporters (OCTs) are members of the solute carrier 22 family of transporter proteins that are involved in absorption, distribution, and…”
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Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis by Proctor, William R, Ming, Xin, Bourdet, David, Han, Tianxiang Kevin, Everett, Ruth S, Thakker, Dhiren R

“…Transport proteins in intestinal epithelial cells facilitate absorption of nutrients/compounds that are organic anions, cations, and zwitterions. For two…”
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Cation‐selective transporters are critical to the AMPK‐mediated antiproliferative effects of metformin in human breast cancer cells by Cai, Hao, Zhang, Yunhui, Han, Tianxiang (Kevin), Everett, Ruth S., Thakker, Dhiren R.

“…The antidiabetic drug metformin exerts antineoplastic effects against breast cancer and other cancers. One mechanism by which metformin is believed to exert…”
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Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib by Morin, Gabriel, Degrugillier-Chopinet, Caroline, Vincent, Marie, Fraissenon, Antoine, Aubert, Hélène, Chapelle, Célia, Hoguin, Clément, Dubos, François, Catteau, Benoit, Petit, Florence, Mezel, Aurélie, Domanski, Olivia, Herbreteau, Guillaume, Alesandrini, Marie, Boddaert, Nathalie, Boutry, Nathalie, Broissand, Christine, Han, Tianxiang Kevin, Branle, Fabrice, Sarnacki, Sabine, Blanc, Thomas, Guibaud, Laurent, Canaud, Guillaume

“…PIK3CA-related overgrowth spectrum (PROS) includes rare genetic conditions due to gain-of-function mutations in the PIK3CA gene. There is no approved medical…”
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Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells: Transporters in metformin effect against breast cancer cells by Cai, Hao, Zhang, Yunhui, Han, Tianxiang Kevin, Everett, Ruth S., Thakker, Dhiren R.

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Combination of pasireotide and octreotide: effects on GH and IGF-I secretion and glucose metabolism in healthy volunteers by Tauchmanova, Libuse, Breitschaft, Astrid, Holder, Geoffrey, Han, Kevin Tianxiang, Choudhury, Somesh, Darstein, Christelle, Paul, Michaela, Drutinus, Eric, Gericke, Germo, Schmid, Herbert A., Pedroncelli, Alberto M.

“…Purpose To assess the pharmacokinetics, pharmacodynamics and tolerability of different doses of octreotide and pasireotide (subcutaneous [sc] and long-acting…”
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