Search Results - "Han, Jiami"

Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain by Taft, Joseph M., Weber, Cédric R., Gao, Beichen, Ehling, Roy A., Han, Jiami, Frei, Lester, Metcalfe, Sean W., Overath, Max D., Yermanos, Alexander, Kelton, William, Reddy, Sai T.

“…The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines and neutralizing antibodies threaten to prolong the…”
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Simvastatin functions as a heat shock protein 90 inhibitor against triple‐negative breast cancer by Kou, Xinhui, Jiang, Xiaoxiao, Liu, Huijuan, Wang, Xuan, Sun, Fanghui, Han, Jiami, Fan, Jiaxing, Feng, Guize, Lin, Zhaohu, Jiang, Lan, Yang, Yonghua

“…Acetylation plays an important role in regulating the chaperone activity of heat shock protein 90 (Hsp90) during malignant transformation through the…”
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TLR7 Signaling Shapes and Maintains Antibody Diversity Upon Virus-Like Particle Immunization by Chang, Xinyue, Krenger, Pascal, Krueger, Caroline C, Zha, Lisha, Han, Jiami, Yermanos, Alexander, Roongta, Salony, Mohsen, Mona O, Oxenius, Annette, Vogel, Monique, Bachmann, Martin F

“…Virus-like particles (VLPs) are used in different marketed vaccines and are able to induce potent antibody responses. The innate pattern recognition receptors…”
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DeepSARS: simultaneous diagnostic detection and genomic surveillance of SARS-CoV-2 by Yermanos, Alexander, Hong, Kai-Lin, Agrafiotis, Andreas, Han, Jiami, Nadeau, Sarah, Valenzuela, Cecilia, Azizoglu, Asli, Ehling, Roy, Gao, Beichen, Spahr, Michael, Neumeier, Daniel, Chang, Ching-Hsiang, Dounas, Andreas, Petrillo, Ezequiel, Nissen, Ina, Burcklen, Elodie, Feldkamp, Mirjam, Beisel, Christian, Oxenius, Annette, Savic, Miodrag, Stadler, Tanja, Rudolf, Fabian, Reddy, Sai T

“…The continued spread of SARS-CoV-2 and emergence of new variants with higher transmission rates and/or partial resistance to vaccines has further highlighted…”
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Learning what not to select for in antibody drug discovery by Gao, Beichen, Han, Jiami, Reddy, Sai T.

“…Identifying antibodies with high affinity and target specificity is crucial for drug discovery and development; however, filtering out antibody candidates with…”
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Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single‐cell analysis by Neumeier, Daniel, Pedrioli, Alessandro, Genovese, Alessandro, Sandu, Ioana, Ehling, Roy, Hong, Kai‐Lin, Papadopoulou, Chrysa, Agrafiotis, Andreas, Kuhn, Raphael, Shlesinger, Danielle, Robbiani, Damiano, Han, Jiami, Hauri, Laura, Csepregi, Lucia, Greiff, Victor, Merkler, Doron, Reddy, Sai T., Oxenius, Annette, Yermanos, Alexander

“…Plasma cells and their secreted antibodies play a central role in the long‐term protection against chronic viral infection. However, due to experimental…”
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ePlatypus: an ecosystem for computational analysis of immunogenomics data by Cotet, Tudor-Stefan, Agrafiotis, Andreas, Kreiner, Victor, Kuhn, Raphael, Shlesinger, Danielle, Manero-Carranza, Marcos, Khodaverdi, Keywan, Kladis, Evgenios, Desideri Perea, Aurora, Maassen-Veeters, Dylan, Glänzer, Wiona, Massery, Solène, Guerci, Lorenzo, Hong, Kai-Lin, Han, Jiami, Stiklioraitis, Kostas, D’Arcy, Vittoria Martinolli, Dizerens, Raphael, Kilchenmann, Samuel, Stalder, Lucas, Nissen, Leon, Vogelsanger, Basil, Anzböck, Stine, Laslo, Daria, Bakker, Sophie, Kondorosy, Melinda, Venerito, Marco, Sanz García, Alejandro, Feller, Isabelle, Oxenius, Annette, Reddy, Sai T, Yermanos, Alexander

“…Abstract Motivation The maturation of systems immunology methodologies requires novel and transparent computational frameworks capable of integrating diverse…”
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Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes by Yermanos, Alexander, Agrafiotis, Andreas, Kuhn, Raphael, Robbiani, Damiano, Yates, Josephine, Papadopoulou, Chrysa, Han, Jiami, Sandu, Ioana, Weber, Cédric, Bieberich, Florian, Vazquez-Lombardi, Rodrigo, Dounas, Andreas, Neumeier, Daniel, Oxenius, Annette, Reddy, Sai T

“…Abstract High-throughput single-cell sequencing (scSeq) technologies are revolutionizing the ability to molecularly profile B and T lymphocytes by offering the…”
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Echidna: integrated simulations of single-cell immune receptor repertoires and transcriptomes by Han, Jiami, Masserey, Solène, Shlesinger, Danielle, Kuhn, Raphael, Papadopoulou, Chrysa, Agrafiotis, Andreas, Kreiner, Victor, Dizerens, Raphael, Hong, Kai-Lin, Weber, Cédric, Greiff, Victor, Oxenius, Annette, Reddy, Sai T, Yermanos, Alexander

“…Single-cell sequencing now enables the recovery of full-length immune receptor repertoires [B cell receptor (BCR) and T cell receptor (TCR) repertoires], in…”
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