Search Results - "Han, Jeehae"

DDS promotes longevity through a microbiome-mediated starvation signal by Choi, Haeri, Cho, Sung Chun, Ha, Young Wan, Ocampo, Billie, Park, Shirley, Chen, Shiwen, Bennett, Christopher F., Han, Jeehae, Rossner, Ryan, Kang, Jong-Sun, Lee, Yun-ll, Park, Sang Chul, Kaeberlein, Matt

“…The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously…”
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PKC downregulation upon rapamycin treatment attenuates mitochondrial disease by Martin-Perez, Miguel, Grillo, Anthony S., Ito, Takashi K., Valente, Anthony S., Han, Jeehae, Entwisle, Samuel W., Huang, Heather Z., Kim, Dayae, Yajima, Masanao, Kaeberlein, Matt, Villén, Judit

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A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A by Simon, Matthew, Yang, Jiping, Gigas, Jonathan, Earley, Eric J, Hillpot, Eric, Zhang, Lei, Zagorulya, Maria, Tombline, Greg, Gilbert, Michael, Yuen, Samantha L, Pope, Alexis, Van Meter, Michael, Emmrich, Stephan, Firsanov, Denis, Athreya, Advait, Biashad, Seyed Ali, Han, Jeehae, Ryu, Seungjin, Tare, Archana, Zhu, Yizhou, Hudgins, Adam, Atzmon, Gil, Barzilai, Nir, Wolfe, Aaron, Moody, Kelsey, Garcia, Benjamin A, Thomas, David D, Robbins, Paul D, Vijg, Jan, Seluanov, Andrei, Suh, Yousin, Gorbunova, Vera

“…Sirtuin 6 (SIRT6) is a deacylase and mono‐ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism…”
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Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing by Ryu, Seungjin, Han, Jeehae, Norden-Krichmar, Trina M, Schork, Nicholas J, Suh, Yousin

“…Identification of all genetic variants associated with complex traits is one of the most important goals in modern human genetics. Genome-wide association…”
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Genetic signature of human longevity in PKC and NF‐κB signaling by Ryu, Seungjin, Han, Jeehae, Norden‐Krichmar, Trina M., Zhang, Quanwei, Lee, Seunggeun, Zhang, Zhengdong, Atzmon, Gil, Niedernhofer, Laura J., Robbins, Paul D., Barzilai, Nir, Schork, Nicholas J., Suh, Yousin

“…Gene variants associated with longevity are also associated with protection against cognitive decline, dementia and Alzheimer's disease, suggesting that common…”
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Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews by Han, Jeehae, Atzmon, Gil, Barzilai, Nir, Suh, Yousin

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Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A by Simon, Matthew, Yang, Jiping, Gigas, Jonathan, Earley, Eric J, Hillpot, Eric, Zhang, Lei, Zagorulya, Maria, Tombline, Greg, Gilbert, Michael, Yuen, Samantha L, Pope, Alexis, Van Meter, Michael, Emmrich, Stephan, Firsanov, Denis, Athreya, Advait, Biashad, Seyed Ali, Han, Jeehae, Ryu, Seungjin, Tare, Archana, Zhu, Yizhou, Hudgins, Adam, Atzmon, Gil, Barzilai, Nir, Wolfe, Aaron, Moody, Kelsey, Garcia, Benjamin A, Robbins, Paul D, Vijg, Jan, Seluanov, Andrei, Suh, Yousin, Gorbunova, Vera

“…Graphical Abstract…”
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A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A by Simon, Matthew, Yang, Jiping, Gigas, Jonathan, Earley, Eric J, Hillpot, Eric, Zhang, Lei, Zagorulya, Maria, Tombline, Greg, Gilbert, Michael, Yuen, Samantha L, Pope, Alexis, Van Meter, Michael, Emmrich, Stephan, Firsanov, Denis, Athreya, Advait, Biashad, Seyed Ali, Han, Jeehae, Ryu, Seungjin, Tare, Archana, Zhu, Yizhou, Hudgins, Adam, Atzmon, Gil, Barzilai, Nir, Wolfe, Aaron, Moody, Kelsey, Garcia, Benjamin A, Robbins, Paul D, Vijg, Jan, Seluanov, Andrei, Suh, Yousin, Gorbunova, Vera

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Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews by Han, Jeehae, Atzmon, Gil, Barzilai, Nir, Suh, Yousin

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Effects of high-dose rapamycin on health and metabolism in mice by Bitto, Alessandro, Yanos, Melana, Ito, Takashi, Han, Jeehae, Sutlief, Elissa, Vizzini, Nicholas, Tung, Herman, Kaeberlein, Matt

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PKC downregulation upon rapamycin treatment attenuates mitochondrial disease by Martin-Perez, Miguel, Grillo, Anthony S., Ito, Takashi K., Valente, Anthony S., Han, Jeehae, Entwisle, Samuel W., Huang, Heather Z., Kim, Dayae, Yajima, Masanao, Kaeberlein, Matt, Villén, Judit

“…Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial function. Mechanistic target of rapamycin (mTOR) inhibition with rapamycin…”
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Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing by Han, Jeehae, Ryu, Seungjin, Moskowitz, David M., Rothenberg, Devorah, Leahy, Daniel J., Atzmon, Gil, Barzilai, Nir, Suh, Yousin

“…► Aim to study the role of rare functional variants in human longevity. ► Implementation of target capture and next-generation sequencing. ► Comprehensive…”
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Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene by Han, Jeehae, Hubbard, Basil P., Lee, Jaehoon, Montagna, Cristina, Lee, Han-Woong, Sinclair, David A., Suh, Yousin

“…SIRT1 is an evolutionarily conserved protein deacetylase that modulates stress response, cellular metabolism and aging in model organisms. While SIRT1 exerts…”
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A functional genomics approach to elucidate the role of genome maintenance in human longevity by Han, Jeehae

“…The genetic control of longevity and pro-longevity phenotypes is likely to be determined by subtle variations in many genes involved in multiple genetic…”
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Molecular mechanisms of a disease susceptibility variant of SIRT1: Genotoxic stress‐induced, CTCF‐dependent activation of SIRT1 gene expression by Song, Xiaoyuan, Cho, Miook, Han, Jeehae, Hazuda, Helen, Duggirala, Ravindranath, Blangero, John, Rosenfeld, Michael G., Suh, Yousin

“…SIRT1 is an evolutionarily conserved protein deacetylase that modulates life span and stress resistance in model organisms. While increased expression of SIRT1…”
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A functional genomics approach to elucidate the role of genome maintenance in human longevity by Han, Jeehae

“…The genetic control of longevity and pro-longevity phenotypes is likely to be determined by subtle variations in many genes involved in multiple genetic…”
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