A study of genetic variants associated with skin traits in the Vietnamese population

Most skin-related traits have been studied in Caucasian genetic backgrounds. A comprehensive study on skin-associated genetic effects on underrepresented populations such as Vietnam is needed to fill the gaps in the field. We aimed to develop a computational pipeline to predict the effect of genetic...

Full description

Saved in:

Bibliographic Details
Published in:	BMC genomics Vol. 25; no. 1; p. 52
Main Authors:	Hoang, Tham Hong, Vu, Duc Minh, Vu, Giang Minh, Nguyen, Thien Khac, Do, Nguyet Minh, Duong, Vinh Chi, Pham, Thang Luong, Tran, Mai Hoang, Khanh Nguyen, Ly Thi, Han, Han Thi Tuong, Can, Thu-Thuy, Pham, Thai Hong, Pham, Tho Duc, Nguyen, Thanh Hong, Do, Huy Phuoc, Vo, Nam S, Nguyen, Xuan-Hung
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 11-01-2024 BioMed Central BMC
Subjects:	Aging Analysis Arrays Candidate genes Collagen Comparative analysis Consent Correlation analysis Database industry Datasets Dermatology DNA sequencing Eating behavior Gene loci Gene sequencing Genes Genetic diversity Genetic effects Genetic factors Genetic Predisposition to Disease Genetic variance Genetic variation Genome-Wide Association Study Genomes Genomic variants Genomics Genotyping Humans Nucleotide sequencing Phenotype Polymorphism, Single Nucleotide Population Population genetics Population studies Populations Questionnaires Single-nucleotide polymorphism Skin Skin diseases Skin health Skin-related traits Southeast Asian People Sunburn & sun tanning Vietnam Vietnamese cohort Whole genome sequencing Vietnam United Kingdom China Skin health Skin-related traits Genomic variants Vietnamese cohort Candidate genes
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Most skin-related traits have been studied in Caucasian genetic backgrounds. A comprehensive study on skin-associated genetic effects on underrepresented populations such as Vietnam is needed to fill the gaps in the field. We aimed to develop a computational pipeline to predict the effect of genetic factors on skin traits using public data (GWAS catalogs and whole-genome sequencing (WGS) data from the 1000 Genomes Project-1KGP) and in-house Vietnamese data (WGS and genotyping by SNP array). Also, we compared the genetic predispositions of 25 skin-related traits of Vietnamese population to others to acquire population-specific insights regarding skin health. Vietnamese cohorts of whole-genome sequencing (WGS) of 1008 healthy individuals for the reference and 96 genotyping samples (which do not have any skin cutaneous issues) by Infinium Asian Screening Array-24 v1.0 BeadChip were employed to predict skin-associated genetic variants of 25 skin-related and micronutrient requirement traits in population analysis and correlation analysis. Simultaneously, we compared the landscape of cutaneous issues of Vietnamese people with other populations by assessing their genetic profiles. The skin-related genetic profile of Vietnamese cohorts was similar at most to East Asian cohorts (JPT: Fst = 0.036, CHB: Fst = 0.031, CHS: Fst = 0.027, CDX: Fst = 0.025) in the population study. In addition, we identified pairs of skin traits at high risk of frequent co-occurrence (such as skin aging and wrinkles (r = 0.45, p = 1.50e-5) or collagen degradation and moisturizing (r = 0.35, p = 1.1e-3)). This is the first investigation in Vietnam to explore genetic variants of facial skin. These findings could improve inadequate skin-related genetic diversity in the currently published database.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-2164 1471-2164
DOI:	10.1186/s12864-023-09932-y