Search Results - "Han, Dasol"

Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate by Carrettiero, Daniel C., Almeida, Maria C., Longhini, Andrew P., Rauch, Jennifer N., Han, Dasol, Zhang, Xuemei, Najafi, Saeed, Gestwicki, Jason E., Kosik, Kenneth S.

“…The formation of membraneless organelles can be a proteotoxic stress control mechanism that locally condenses a set of components capable of mediating protein…”
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Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation by Han, Dasol, Longhini, Andrew P, Zhang, Xuemei, Hoang, Vivian, Wilson, Maxwell Z, Kosik, Kenneth S

“…m6A methylation is the most abundant and reversible chemical modification on mRNA with approximately one-fourth of eukaryotic mRNAs harboring at least one…”
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ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells by Han, Dasol, Liu, Guojing, Oh, Yujeong, Oh, Seyoun, Yang, Seungbok, Mandjikian, Lori, Rani, Neha, Almeida, Maria C., Kosik, Kenneth S., Jang, Jiwon

“…Development is generally viewed as one-way traffic of cell state transition from primitive to developmentally advanced states. However, molecular mechanisms…”
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Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation by Han, Dasol, Kwon, Mookwang, Lee, Sun Min, Pleasure, Samuel J., Yoon, Keejung

“…Although astrocytes have gained increased recognition as an important regulator in normal brain function and pathology, the mechanisms underlying their genesis…”
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YAP inhibits HCMV replication by impairing STING-mediated nuclear transport of the viral genome by Lee, Ju Hyun, Kwon, Mookwang, Lim, Woo Young, Yoo, Chae Rin, Yoon, Youngik, Han, Dasol, Ahn, Jin-Hyun, Yoon, Keejung

“…YES-associated protein (YAP), a critical actor of the mammalian Hippo signaling pathway involved in diverse biological events, has gained increased recognition…”
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Human Cytomegalovirus IE2 Protein Disturbs Brain Development by the Dysregulation of Neural Stem Cell Maintenance and the Polarization of Migrating Neurons by Han, Dasol, Byun, Sung-Hyun, Kim, Juwan, Kwon, Mookwang, Pleasure, Samuel J, Ahn, Jin-Hyun, Yoon, Keejung

“…Despite the high incidence of severe defects in the central nervous system caused by human cytomegalovirus (HCMV) congenital infection, the mechanism of HCMV…”
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Control over single-cell distribution of G1 lengths by WNT governs pluripotency by Jang, Jiwon, Han, Dasol, Golkaram, Mahdi, Audouard, Morgane, Liu, Guojing, Bridges, Daniel, Hellander, Stefan, Chialastri, Alex, Dey, Siddharth S, Petzold, Linda R, Kosik, Kenneth S

“…The link between single-cell variation and population-level fate choices lacks a mechanistic explanation despite extensive observations of gene expression and…”
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Neprilysin facilitates adipogenesis through potentiation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway by Kim, Juwan, Han, Dasol, Byun, Sung-Hyun, Kwon, Mookwang, Cho, Sun-Jung, Koh, Young Ho, Yoon, Keejung

“…Neprilysin (NEP) is a zinc metallopeptidase that cleaves a number of small peptides into inactive forms. Despite the recent evidence of a significant…”
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TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway by Byun, Sung-Hyun, Kim, Juwan, Han, Dasol, Kwon, Mookwang, Cho, Jae Youl, Ng, Hui Xuan, Pleasure, Samuel J, Yoon, Keejung

“…Transactivation response element RNA-binding protein (TRBP; TARBP2) is known to play important roles in human immunodeficiency virus (HIV) replication and…”
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Dynamic assembly of the mRNA m.sup.6A methyltransferase complex is regulated by METTL3 phase separation by Han, Dasol, Longhini, Andrew P, Zhang, Xuemei, Hoang, Vivian, Wilson, Maxwell Z, Kosik, Kenneth S

“…m.sup.6 A methylation is the most abundant and reversible chemical modification on mRNA with approximately one-fourth of eukaryotic mRNAs harboring at least…”
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SeeThroughNet: Resurrection of Auxiliary Loss by Preserving Class Probability Information by Han, Dasol, Yoo, Jaewook, Oh, Dokwan

“…Auxiliary loss is additional loss besides the main branch loss to help optimize the learning process of neural networks. In order to calculate the auxiliary…”
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Dynamic Text: How to Effectively Embed Emotions in Text-based Computer-Mediated Communication by Han, Dasol, Hamka, Sukayna, Kim, Sang-Hwan

“…Despite being an effective mode of communication, Computer-Mediated Communication (CMC), particularly regarding text-based exchanges, still has inherent…”
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Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission by Lach, Ryan S, Qiu, Chongxu, Kajbaf, Erfan Zeyaei, Baxter, Naomi, Han, Dasol, Wang, Alex, Lock, Hannah, Chirikian, Orlando, Pruitt, Beth, Wilson, Maxwell Z

“…Wnt signal transduction is controlled by the destruction complex (DC), a condensate comprising scaffold proteins and kinases that regulate β-catenin stability…”
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YAP/TAZ enhance mammalian embryonic neural stem cell characteristics in a Tead-dependent manner by Han, Dasol, Byun, Sung-Hyun, Park, Soojeong, Kim, Juwan, Kim, Inhee, Ha, Soobong, Kwon, Mookwang, Yoon, Keejung

“…Mammalian brain development is regulated by multiple signaling pathways controlling cell proliferation, migration and differentiation. Here we show that…”
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Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway by Kim, Juwan, Han, Dasol, Byun, Sung‐Hyun, Kwon, Mookwang, Cho, Jae Youl, Pleasure, Samuel J, Yoon, Keejung

“…Despite growing evidence linking Drosophila melanogaster tweety‐homologue 1 (Ttyh1) to normal mammalian brain development and cell proliferation, its exact…”
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Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer's disease profile and possible mechanisms of disease protection by Almeida, Maria Camila, Eger, Sarah J, He, Caroline, Audouard, Morgane, Nikitina, Arina, Glasauer, Stella M K, Han, Dasol, Mejía-Cupajita, Barbara, Acosta-Uribe, Juliana, Villalba-Moreno, Nelson David, Littau, Jessica Lisa, Elcheikhali, Megan, Rivera, Erica Keane, Carrettiero, Daniel Carneiro, Villegas-Lanau, Carlos Andrés, Sepulveda-Falla, Diego, Lopera, Francisco, Kosik, Kenneth S

“…Highly penetrant autosomal dominant Alzheimer's disease (ADAD) comprises a distinct disease entity as compared to the far more prevalent form of AD in which…”
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Gamma secretase inhibition impairs HCMV replication by reduction of immediate early gene expression at the transcriptional level by Lee, Sun Min, Han, Dasol, Kwon, Mookwang, Noh, Hogyun, Lee, Ju Hyun, Yoon, Youngik, Cho, Jae Youl, Ahn, Jin-Hyun, Yoon, Keejung

“…Due to diverse pathogenic potentials, there is a growing need for anti-HCMV agents. In this study, we show that treatment with DAPT, a γ-secretase inhibitor…”
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TRBP maintains mammalian embryonic neural stem cell properties by enhancing the Notch signaling pathway as a novel transcriptional coactivator by Byun, Sung-Hyun, Kim, Juwan, Han, Dasol, Kwon, Mookwang, Cho, Jae Youl, Ng, Hui Xuan, Pleasure, Samuel J., Yoon, Keejung

“…Transactivation response element RNA-binding protein (TRBP) is known to play important roles in human immunodeficiency virus (HIV) replication and microRNA…”
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Creatine inhibits adipogenesis by downregulating insulin-induced activation of the phosphatidylinositol 3-kinase signaling pathway by Lee, Nayeon, Kim, Inhee, Park, Soojeong, Han, Dasol, Ha, Soobong, Kwon, Mookwang, Kim, Juwan, Byun, Sung-Hyun, Oh, Wonil, Jeon, Hong Bae, Kweon, Dae-Hyuk, Cho, Jae Youl, Yoon, Keejung

“…Creatine is a nitrogenous organic acid known to function in adenosine triphosphate (ATP) metabolism. Recent evidence indicates that creatine regulates the…”
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Notch intracellular domain deficiency in nuclear localization activity retains the ability to enhance neural stem cell character and block neurogenesis in mammalian brain development by Jang, Jiwon, Byun, Sung-Hyun, Han, Dasol, Lee, Junsub, Kim, Juwan, Lee, Nayeon, Kim, Inhee, Park, Soojeong, Ha, Soobong, Kwon, Mookwang, Ahn, Jyhyun, Chung, Woo-Jae, Kweon, Dae-Hyuk, Cho, Jae Youl, Kim, Sunyoung, Yoon, Keejung

“…Notch has a broad range of regulatory functions in many developmental processes, including hematopoiesis, neurogenesis, and angiogenesis. Notch has several key…”
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