Chemokine-Driven Migration of Pro-Inflammatory CD4 + T Cells in CNS Autoimmune Disease

Pro-inflammatory CD4 T helper (Th) cells drive the pathogenesis of many autoimmune conditions. Recent advances have modified views of the phenotype of pro-inflammatory Th cells in autoimmunity, extending the breadth of known Th cell subsets that operate as drivers of these responses. Heterogeneity a...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 13; p. 817473
Main Authors:	Heng, Aaron H S, Han, Caleb W, Abbott, Caitlin, McColl, Shaun R, Comerford, Iain
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 16-02-2022
Subjects:	Animals CD4-Positive T-Lymphocytes Central Nervous System Diseases - metabolism chemokine Chemokines - metabolism EAE (experimental autoimmune encephalomyelitis) Encephalomyelitis, Autoimmune, Experimental Immunology migration multiple sclerosis Receptors, Chemokine - metabolism Th subsets Th17 Cells migration chemokine EAE (experimental autoimmune encephalomyelitis) multiple sclerosis Th subsets
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Summary:	Pro-inflammatory CD4 T helper (Th) cells drive the pathogenesis of many autoimmune conditions. Recent advances have modified views of the phenotype of pro-inflammatory Th cells in autoimmunity, extending the breadth of known Th cell subsets that operate as drivers of these responses. Heterogeneity and plasticity within Th1 and Th17 cells, and the discovery of subsets of Th cells dedicated to production of other pro-inflammatory cytokines such as GM-CSF have led to these advances. Here, we review recent progress in this area and focus specifically upon evidence for chemokine receptors that drive recruitment of these various pro-inflammatory Th cell subsets to sites of autoimmune inflammation in the CNS. We discuss expression of specific chemokine receptors by subsets of pro-inflammatory Th cells and highlight which receptors may be tractable targets of therapeutic interventions to limit pathogenic Th cell recruitment in autoimmunity.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Gordana Leposavić, University of Belgrade, Serbia This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology Reviewed by: Cheng-Chih Hsiao, Amsterdam University Medical Center, Netherlands; Barbara Rossi, University of Verona, Italy; Makoto Inoue, University of Illinois at Urbana-Champaign, United States
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2022.817473