Search Results - "Han, Bingsong"

Unintentional injury and its associated factors among left-behind children: a cross-sectional study by Jin, Zhiyu, Han, Bingsong, He, Jing, Huang, Xinyuan, Chen, Kun, Wang, Jiana, Liu, Zhuang

“…Unintentional injuries among children and adolescents are a major public health problem worldwide. These injuries not only have negative effects on children's…”
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Aggressive behaviors and associated factors in Chinese left-behind adolescents: a cross-sectional study by Yang, Fang, Jin, Zhiyu, He, Jing, Han, Bingsong, Huang, Xinyuan, Chen, Kun, Wang, Jiana

“…Background To examine whether the levels of aggressive behaviors and other individual and contextual variables differ between left-behind adolescents (LBA) and…”
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Effect of parenting style on the emotional and behavioral problems among Chinese adolescents: the mediating effect of resilience by Wang, Jiana, Huang, Xinyuan, Li, Zhe, Chen, Kun, Jin, Zhiyu, He, Jing, Han, Bingsong, Feng, Lin, Meng, Nana, Yang, Cong, Liu, Zhuang

“…Although previous studies have found that parenting style significantly predicts emotional and behavioral problems (EBPs) among Chinese adolescents, the…”
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Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors by Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Gunzner-Toste, Janet, Liederer, Bianca M, Ly, Justin, O’Brien, Thomas, Oh, Angela, Wang, Leslie, Wang, Weiru, Xiao, Yang, Zak, Mark, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W

“…Crystal structures of several urea- and thiourea-derived compounds in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein were utilized to…”
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Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors by Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Gunzner-Toste, Janet, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W

“…Nicotinamide phosphoribosyltransferase (Nampt) is a promising anticancer target. Virtual screening identified a thiourea analogue, compound 5, as a novel…”
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Parent-child attachment mediates the association between parental conflict perceptions and suicide intention: a cross-sectional survey among middle school students in China by Wang, Jiana, Chen, Kun, Huang, Xinyuan, Jin, Zhiyu, He, Jing, Han, Bingsong, Feng, Lin, Meng, Nana, Yang, Cong, Yao, Pin, Li, Zhe

“…Adolescent suicide is a prevalent issue globally, with various factors contributing to this phenomenon. This study aimed to investigate these factors and their…”
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Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors by Zheng, Xiaozhang, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Wang, Yunli, Yuen, Po-Wai, Bair, Kenneth W

“…A co-crystal structure of amide-containing compound (4) in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein and molecular modeling were…”
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Impact of Allosteric Modulation in Drug Discovery: Innovation in Emerging Chemical Modalities by Han, Bingsong, Salituro, Francesco G, Blanco, Maria-Jesus

“…Recent years have seen an unprecedented level of innovation in allosteric drug discovery and development, with multiple drug candidates advancing into clinical…”
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Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6 by Kerres, Nina, Steurer, Steffen, Schlager, Stefanie, Bader, Gerd, Berger, Helmut, Caligiuri, Maureen, Dank, Christian, Engen, John R., Ettmayer, Peter, Fischerauer, Bernhard, Flotzinger, Gerlinde, Gerlach, Daniel, Gerstberger, Thomas, Gmaschitz, Teresa, Greb, Peter, Han, Bingsong, Heyes, Elizabeth, Iacob, Roxana E., Kessler, Dirk, Kölle, Heike, Lamarre, Lyne, Lancia, David R., Lucas, Simon, Mayer, Moriz, Mayr, Katharina, Mischerikow, Nikolai, Mück, Katja, Peinsipp, Christoph, Petermann, Oliver, Reiser, Ulrich, Rudolph, Dorothea, Rumpel, Klaus, Salomon, Carina, Scharn, Dirk, Schnitzer, Renate, Schrenk, Andreas, Schweifer, Norbert, Thompson, Diane, Traxler, Elisabeth, Varecka, Roland, Voss, Tilman, Weiss-Puxbaum, Alexander, Winkler, Sandra, Zheng, Xiaozhang, Zoephel, Andreas, Kraut, Norbert, McConnell, Darryl, Pearson, Mark, Koegl, Manfred

“…The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its…”
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Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11 by Martin, Matthew W., Lee, Jennifer Y., Lancia, David R., Ng, Pui Yee, Han, Bingsong, Thomason, Jennifer R., Lynes, Maureen S., Marshall, C. Gary, Conti, Chiara, Collis, Alan, Morales, Monica Alvarez, Doshi, Kshama, Rudnitskaya, Aleksandra, Yao, Lili, Zheng, Xiaozhang

“…[Display omitted] •Identified novel, potent, and selective first-in-class inhibitors of HDAC11.•Synthesis and structure activity relationships of compounds are…”
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Abstract 3354: Chemically induced degradation of the transcription factor BCL6 by Kerres, Nina, Steurer, Steffen, Schlager, Stefanie, Bader, Gerd, Caligiuri, Maureen, Dank, Christian, Engen, John R., Ettmayer, Peter, Gerlach, Daniel, Gerstberger, Thomas, Han, Bingsong, Iacob, Roxana E., Kessler, Dirk, Lancia, David R., Moriz, Mayer, Mischerikow, Nikolai, Rumpel, Klaus, Schnitzer, Renate, Voss, Tilman, Zheng, Xiaozhang, Zoephel, Andreas, Kraut, Norbert, McConnell, Darryl, Pearson, Mark, Koegl, Manfred

“…The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B-cell lymphoma (DLBCL). Disruption of its…”
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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) by Zheng, Xiaozhang, Bair, Kenneth W., Bauer, Paul, Baumeister, Timm, Bowman, Krista K., Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Feng, Yezhen, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Li, Hong, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Ly, Justin, O’Brien, Thomas, Oeh, Jason, Oh, Angela, Reynolds, Dominic J., Sampath, Deepak, Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Tremayne, Jarrod, Wang, Leslie, Wang, Weiru, Wang, Zhongguo, Wu, Hongxing, Wu, Jiansheng, Xiao, Yang, Yang, Guangxing, Yuen, Po-wai, Zak, Mark, Dragovich, Peter S.

“…Potent, 1H-pyrazolo[3,4-b]pyridine-containing inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified using…”
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Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility by Zak, Mark, Liederer, Bianca M., Sampath, Deepak, Yuen, Po-wai, Bair, Kenneth W., Baumeister, Timm, Buckmelter, Alexandre J., Clodfelter, Karl H., Cheng, Eric, Crocker, Lisa, Fu, Bang, Han, Bingsong, Li, Guangkun, Ho, Yen-Ching, Lin, Jian, Liu, Xiongcai, Ly, Justin, O’Brien, Thomas, Reynolds, Dominic J., Skelton, Nicholas, Smith, Chase C., Tay, Suzanne, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Zhang, Lei, Zhao, Guiling, Zheng, Xiaozhang, Dragovich, Peter S.

“…[Display omitted] Herein we report the optimization efforts to ameliorate the potent CYP3A4 time-dependent inhibition (TDI) and low aqueous solubility…”
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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties by Gunzner-Toste, Janet, Zhao, Guiling, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Fu, Bang, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Mukadam, Sophie, O’Brien, Thomas, Oh, Angela, Reynolds, Dominic J., Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Sodhi, Jasleen, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhang, Lei, Zheng, Xiaozhang, Bair, Kenneth W., Dragovich, Peter S.

“…Potent, reversible inhibition of the cytochrome P450 CYP2C9 isoform was observed in a series of urea-containing nicotinamide phosphoribosyltransferase (NAMPT)…”
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Development of a Scaleable Synthesis of NDT 9533750, a Key Intermediate to a Series of Novel Subtype Preferring GABA A Partial Agonists by Xu, Yuelian, Han, Bingsong, Wang, Zhe-Qing, Shaw, Kenneth R., Chenard, Bertrand L., Maynard, George, Xie, Linghong

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Development of a Scaleable Synthesis of NDT 9533750, a Key Intermediate to a Series of Novel Subtype Preferring GABAA Partial Agonists by Xu, Yuelian, Han, Bingsong, Wang, Zhe-Qing, Shaw, Kenneth R, Chenard, Bertrand L, Maynard, George, Xie, Linghong

“…A scaleable route to 6-chloro-4-[2-(3-fluoropyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine (NDT 9533750), a key intermediate to a series of novel…”
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Synthetic studies on roseophilin, pentalongin and selected angucyclines by Han, Bingsong

“…Synthetic studies on roseophilin, pentalongin and two angucyclines are described. Part I. Roseophilin: Two different model studies were tested to synthesize…”
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Synthetic studies on roseophilin, pentalongin and selected angucyclines by Han, Bingsong

“…Synthetic studies on roseophilin, pentalongin and two angucyclines are described. Part I. Roseophilin: Two different model studies were tested to synthesize…”
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