Search Results - "Hamstra, Sophie I"

Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight by Braun, Jessica L, Geromella, Mia S, Hamstra, Sophie I, Messner, Holt N, Fajardo, Val A

“…It is well established that microgravity exposure causes significant muscle weakness and atrophy via muscle unloading. On Earth, muscle unloading leads to a…”
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SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin‐deficient mice by Braun, Jessica L., Hamstra, Sophie I., Messner, Holt N., Fajardo, Val A.

“…The sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) is imperative for normal cardiac function regulating both muscle relaxation and contractility. SERCA2a is…”
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Neuronatin regulates whole‐body metabolism: is thermogenesis involved? by Braun, Jessica L., Geromella, Mia S., Hamstra, Sophie I., Fajardo, Val A.

“…Neuronatin (NNAT) was originally discovered in 1995 and labeled as a brain developmental gene due to its abundant expression in developing brains. Over the…”
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Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice by Cleverdon, Riley E.G., Braun, Jessica L., Geromella, Mia S., Whitley, Kennedy C., Marko, Daniel M., Hamstra, Sophie I., Roy, Brian D., MacPherson, Rebecca E.K., Fajardo, Val A.

“…The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned…”
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GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production by Whitley, Kennedy C., Hamstra, Sophie I., Baranowski, Ryan W., Watson, Colton J. F., MacPherson, Rebecca E. K., MacNeil, Adam J., Roy, Brian D., Vandenboom, Rene, Fajardo, Val A.

“…Calcineurin is a Ca2+‐dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the…”
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A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells by Kurgan, Nigel, Whitley, Kennedy C, Maddalena, Lucas A, Moradi, Fereshteh, Stoikos, Joshua, Hamstra, Sophie I, Rubie, Elizabeth A, Kumar, Megha, Roy, Brian D, Woodgett, James R, Stuart, Jeffrey A, Fajardo, Val A

“…Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a…”
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Heterozygous SOD2 deletion selectively impairs SERCA function in the soleus of female mice by Braun, Jessica L., Messner, Holt N., Cleverdon, Riley E. G., Baranowski, Ryan W., Hamstra, Sophie I., Geromella, Mia S., Stuart, Jeffrey A., Fajardo, Val A.

“…The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) restores intracellular Ca2+ ([Ca2+]i) to resting levels after muscle contraction, ultimately eliciting…”
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GSK3-inhibition improves maximal SERCA activity in a murine model of Arrhythmogenic cardiomyopathy by Hamstra, Sophie I, Braun, Jessica L, Chelko, Stephen P, Fajardo, Val A

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The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function by Hamstra, Sophie I, Whitley, Kennedy C, Baranowski, Ryan W, Kurgan, Nigel, Braun, Jessica L, Messner, Holt N, Fajardo, Val A

“…Cardiac contractile function is largely mediated by the regulation of Ca cycling throughout the lifespan. The sarco(endo)plasmic reticulum Ca ATPase (SERCA)…”
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Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis by Braun, Jessica L., Geromella, Mia S., Hamstra, Sophie I.

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Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation by Hamstra, Sophie I, Roy, Brian D, Tiidus, Peter, MacNeil, Adam J, Klentrou, Panagiota, MacPherson, Rebecca E K, Fajardo, Val A

“…Lithium is most well-known for its mood-stabilizing effects in the treatment of bipolar disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum…”
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Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca2+ ATPase uncoupling in muscle by Geromella, Mia S., Ryan, Chantal R., Braun, Jessica L., Finch, Michael S., Maddalena, Lucas A., Bagshaw, Olivia, Hockey, Briana L., Moradi, Fereshteh, Fenech, Rachel K., Ryoo, Jisook, Marko, Daniel M., Dhaliwal, Roopan, Sweezey-Munroe, Jake, Hamstra, Sophie I., Gardner, Georgina, Silvera, Sebastian, Vandenboom, Rene, Roy, Brian D., Stuart, Jeffrey A., MacPherson, Rebecca E.K., Fajardo, Val A.

“…Sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) uncoupling in skeletal muscle and mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige…”
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Low-Dose Lithium Supplementation Influences GSK3β Activity in a Brain Region Specific Manner in C57BL6 Male Mice by Fenech, Rachel K, Hamstra, Sophie I, Finch, Michael S, Ryan, Chantal R, Marko, Daniel M, Roy, Brian D, Fajardo, Val A, MacPherson, Rebecca E K

“…Lithium, a commonly used treatment for bipolar disorder, has been shown to have neuroprotective effects for other conditions including Alzheimer's disease via…”
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Low‐dose lithium feeding increases the SERCA2a‐to‐phospholamban ratio, improving SERCA function in murine left ventricles by Hamstra, Sophie I., Kurgan, Nigel, Baranowski, Ryan W., Qiu, Liqun, Watson, Colton J. F., Messner, Holt N., MacPherson, Rebecca E. K., MacNeil, Adam J., Roy, Brian D., Fajardo, Val A.

“…New Findings What is the central question of this study? Inhibition of glycogen synthase kinase‐3 (GSK3) has been shown to improve cardiac SERCA2a function…”
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Glycogen synthase kinase 3 (GSK3) is a critical regulator of allergen-mediated mast cell activation by Crozier, Robert W.E., Hamstra, Sophie I., Fajardo, Val A., MacNeil, Adam J.

“…Abstract Mast cells are granulated immune sentinels responsible for perpetuating allergic inflammatory events. Allergen-induced FcɛRI signaling leads to the…”
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Low‐dose Lithium is Associated with Left Ventricular Ejection Fraction in Healthy Young Men but not Women by Dempster, Kylie S., Fajardo, Val A., Baranowski, Ryan W., Hamstra, Sophie I., Wade, Terrance J., O'Leary, Deborah D.

“…Abstract only The impact of lithium (Li) exposure on the cardiovascular system is perplexing, as beneficial, negative, and null effects have been identified…”
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Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation by Sophie I. Hamstra, Brian D. Roy, Peter Tiidus, Adam J. MacNeil, Panagiota Klentrou, Rebecca E.K. MacPherson, Val A. Fajardo

“…Lithium is most well-known for its mood-stabilizing effects in the treatment of bipolar disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum…”
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Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca 2+ ATPase uncoupling in muscle by Geromella, Mia S, Ryan, Chantal R, Braun, Jessica L, Finch, Michael S, Maddalena, Lucas A, Bagshaw, Olivia, Hockey, Briana L, Moradi, Fereshteh, Fenech, Rachel K, Ryoo, Jisook, Marko, Daniel M, Dhaliwal, Roopan, Sweezey-Munroe, Jake, Hamstra, Sophie I, Gardner, Georgina, Silvera, Sebastian, Vandenboom, Rene, Roy, Brian D, Stuart, Jeffrey A, MacPherson, Rebecca E K, Fajardo, Val A

“…Sarco(endo)plasmic reticulum Ca -ATPase (SERCA) uncoupling in skeletal muscle and mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige…”
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