Search Results - "Hamrick, M. W."

Leptin and the sympathetic connection of fat to bone by Hamrick, M. W., Ferrari, S. L.

“…Loss of body weight is associated with bone loss, and body weight gain is associated with increased bone formation. The molecular mechanisms linking body…”
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Leptin deficiency produces contrasting phenotypes in bones of the limb and spine by Hamrick, M.W, Pennington, C, Newton, D, Xie, D, Isales, C

“…Leptin is a hormone secreted by adipocytes that can regulate bone mass through a central, neuroendocrine signaling pathway. We tested the hypothesis that the…”
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Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading by Hamrick, M.W, Shi, X, Zhang, W, Pennington, C, Thakore, H, Haque, M, Kang, B, Isales, C.M, Fulzele, S, Wenger, K.H

“…Abstract Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking myostatin show a significant increase in muscle mass and bone…”
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Bone and fat relationships in postadolescent black females: a pQCT study by Pollock, N. K, Laing, E. M, Hamrick, M. W, Baile, C. A, Hall, D. B, Lewis, R. D

“…Summary Despite adolescent black females experiencing the highest rates of obesity, the effect of excess fat mass on bone structure and strength in this…”
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25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth by Breen, M. E, Laing, E. M, Hall, D. B, Hausman, D. B, Taylor, R. G, Isales, C. M, Ding, K. H, Pollock, N. K, Hamrick, M. W, Baile, C. A, Lewis, R. D

“…Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear…”
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Resistance to body fat gain in 'double-muscled' mice fed a high-fat diet by HAMRICK, M. W, PENNINGTON, C, WEBB, C. N, ISALES, C. M

“…To determine if myostatin deficiency attenuates body fat gain with increased dietary fat intake. Normal and myostatin-deficient mice were fed control (8-10…”
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Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse by Bettis, T., Kim, B.-J., Hamrick, M. W.

“…Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or…”
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Craniofacial Morphology in Myostatin-deficient Mice by Vecchione, L., Byron, C., Cooper, G.M., Barbano, T., Hamrick, M.W., Sciote, J.J., Mooney, M.P.

“…GDF-8 (myostatin) is a negative growth regulator of skeletal muscle, and myostatin-deficient mice are hypermuscular. Muscle size and force production are…”
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Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice by Hamrick, M.W, McPherron, A.C, Lovejoy, C.O, Hudson, J

“…GDF-8, also known as myostatin, is a member of the transforming growth factor-β (TGF-β) superfamily of secreted growth and differentiation factors that is…”
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25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth by Breen, M. E, Laing, E. M, Hall, D. B, Hausman, D. B, Taylor, R. G, Isales, C. M, Ding, K. H, Pollock, N. K, Hamrick, M. W, Baile, C. A, Lewis, R. D

“…J Clin Endocrinol Metab, published October 20, 2010, 10.1210/jc.2010-0595…”
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25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth by Breen, M. E, Laing, E. M, Hall, D. B, Hausman, D. B, Taylor, R. G, Isales, C. M, Ding, K. H, Pollock, N. K, Hamrick, M. W, Baile, C. A, Lewis, R. D

“…J Clin Endocrinol Metab, published October 20, 2010, 10.1210/jc.2010-0595…”
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Development and evolution of the mammalian limb: adaptive diversification of nails, hooves, and claws by Hamrick, Mark W.

“…SUMMARY Paleontological evidence indicates that the evolutionary diversification of mammals early in the Cenozoic era was characterized by an adaptive…”
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The positive association of total protein intake with femoral neck strength (KNHANES IV) by Kim, B.-J., Lee, S. H., Isales, C. M., Koh, J.-M., Hamrick, M. W.

“…Summary Data gathered from a nationally representative cohort demonstrate that higher dietary protein intake was positively associated with the composite…”
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Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture by Kim, B.-J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H., Koh, J.-M.

“…Summary The plasma n-3 fatty acid level was 26.2% lower in patients with osteoporotic hip fracture than in those with osteoarthritis. In all patients, n-3…”
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Bone mineral content and density in the humerus of adult myostatin-deficient mice by Hamrick, M W, McPherron, A C, Lovejoy, C O

“…Myostatin (GDF-8), a member of the transforming growth factor-b superfamily of secreted growth and differentiation factors, is a negative regulator of skeletal…”
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The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice by Hamrick, M.W., Dukes, A., Arounleut, P., Davis, C., Periyasamy-Thandavan, S., Mork, S., Herberg, S., Johnson, M.H., Isales, C.M., Hill, W.D., Otvos, L., Belin de Chantemèle, E.J.

“…Muscle- and liver-derived IGF-1 play important roles in muscle anabolism throughout growth and aging. Yet, prolonged food restriction is thought to increase…”
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Leptin Treatment Induces Loss of Bone Marrow Adipocytes and Increases Bone Formation in Leptin‐Deficient ob/ob Mice by Hamrick, Mark W, Della‐Fera, Mary Anne, Choi, Yang‐Ho, Pennington, Catherine, Hartzell, Diane, Baile, Clifton A

“…Normal mice and leptin‐deficient ob/ob mice were treated with leptin to study effects on osteogenesis and adipogenesis in bone marrow. Leptin treatment…”
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Increased Muscle Mass With Myostatin Deficiency Improves Gains in Bone Strength With Exercise by Hamrick, Mark W, Samaddar, Ted, Pennington, Catherine, McCormick, John

“…We tested the hypothesis that increased muscle mass augments increases in bone strength normally observed with exercise. Myostatin‐deficient mice, which show…”
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Myostatin (GDF-8) as a key factor linking muscle mass and bone structure by Elkasrawy, M N, Hamrick, M W

“…Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin…”
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Pattern and process in the evolution of primate nails and claws by Hamrick, Mark W.

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