Search Results - "Hampton, David W"

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism by Hasel, Philip, Dando, Owen, Jiwaji, Zoeb, Baxter, Paul, Todd, Alison C., Heron, Samuel, Márkus, Nóra M., McQueen, Jamie, Hampton, David W., Torvell, Megan, Tiwari, Sachin S., McKay, Sean, Eraso-Pichot, Abel, Zorzano, Antonio, Masgrau, Roser, Galea, Elena, Chandran, Siddharthan, Wyllie, David J. A., Simpson, T. Ian, Hardingham, Giles E.

“…The influence that neurons exert on astrocytic function is poorly understood. To investigate this, we first developed a system combining cortical neurons and…”
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Cell-mediated neuroprotection in a mouse model of human tauopathy by Hampton, David W, Webber, Daniel J, Bilican, Bilada, Goedert, Michel, Spillantini, Maria Grazia, Chandran, Siddharthan

“…Tau protein in a hyperphosphorylated state makes up the intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease and cases…”
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HspB5 Activates a Neuroprotective Glial Cell Response in Experimental Tauopathy by Hampton, David W., Amor, Sandra, Story, David, Torvell, Megan, Bsibsi, Malika, van Noort, Johannes M., Chandran, Siddarthan

“…Progressive neuronal death during tauopathies is associated with aggregation of modified, truncated or mutant forms of tau protein. Such aggregates are…”
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A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy by Torvell, Megan, Hampton, David W., Connick, Peter, MacLullich, Alasdair M.J., Cunningham, Colm, Chandran, Siddharthan

“…Neuroinflammation, which contributes to neurodegeneration, is a consistent hallmark of dementia. Emerging evidence suggests that systemic inflammation also…”
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iPSC-derived myelinoids to study myelin biology of humans by James, Owen G., Selvaraj, Bhuvaneish T., Magnani, Dario, Burr, Karen, Connick, Peter, Barton, Samantha K., Vasistha, Navneet A., Hampton, David W., Story, David, Smigiel, Robert, Ploski, Rafal, Brophy, Peter J., ffrench-Constant, Charles, Lyons, David A., Chandran, Siddharthan

“…Myelination is essential for central nervous system (CNS) formation, health, and function. Emerging evidence of oligodendrocyte heterogeneity in health and…”
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CNS macrophages differentially rely on an intronic Csf1r enhancer for their development by Munro, David A D, Bradford, Barry M, Mariani, Samanta A, Hampton, David W, Vink, Chris S, Chandran, Siddharthan, Hume, David A, Pridans, Clare, Priller, Josef

“…The central nervous system hosts parenchymal macrophages, known as microglia, and non-parenchymal macrophages, collectively termed border-associated…”
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Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases by Nutma, Erik, Fancy, Nurun, Weinert, Maria, Tsartsalis, Stergios, Marzin, Manuel C., Muirhead, Robert C. J., Falk, Irene, Breur, Marjolein, de Bruin, Joy, Hollaus, David, Pieterman, Robin, Anink, Jasper, Story, David, Chandran, Siddharthan, Tang, Jiabin, Trolese, Maria C., Saito, Takashi, Saido, Takaomi C., Wiltshire, Katharine H., Beltran-Lobo, Paula, Phillips, Alexandra, Antel, Jack, Healy, Luke, Dorion, Marie-France, Galloway, Dylan A., Benoit, Rochelle Y., Amossé, Quentin, Ceyzériat, Kelly, Badina, Aurélien M., Kövari, Enikö, Bendotti, Caterina, Aronica, Eleonora, Radulescu, Carola I., Wong, Jia Hui, Barron, Anna M., Smith, Amy M., Barnes, Samuel J., Hampton, David W., van der Valk, Paul, Jacobson, Steven, Howell, Owain W., Baker, David, Kipp, Markus, Kaddatz, Hannes, Tournier, Benjamin B., Millet, Philippe, Matthews, Paul M., Moore, Craig S., Amor, Sandra, Owen, David R.

“…Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator…”
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iPSC-derived myelinoids to study myelin biology of humans by James, Owen G., Selvaraj, Bhuvaneish T., Magnani, Dario, Burr, Karen, Connick, Peter, Barton, Samantha K., Vasistha, Navneet A., Hampton, David W., Story, David, Smigiel, Robert, Ploski, Rafal, Brophy, Peter J., ffrench-Constant, Charles, Lyons, David A., Chandran, Siddharthan

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A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo by Hampton, David W., Asher, Richard A., Kondo, Toru, Steeves, John D., Ramer, Matt S., Fawcett, James W.

“…Bone morphogenetic proteins (BMPs) and their endogenous inhibitors, including noggin, chordin and follistatin, have roles in pattern formation and fate…”
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Focal Immune-Mediated White Matter Demyelination Reveals an Age-Associated Increase in Axonal Vulnerability and Decreased Remyelination Efficiency by Hampton, David W, Innes, Neill, Merkler, Doron, Zhao, Chao, Franklin, Robin J.M, Chandran, Siddharthan

“…In addition to being an established risk factor for neurodegenerative diseases, age is increasingly recognized as adversely influencing regeneration…”
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Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage by Strappe, Padraig M, Hampton, David W, Brown, Douglas, Cachon-Gonzalez, Begona, Caldwell, Maeve, Fawcett, James W, Lever, Andrew M L

“…Lentiviral vectors have shown immense promise as vehicles for gene delivery to non-dividing cells particularly to cells of the central nervous system (CNS)…”
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Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism by Hasel, Philip, Dando, Owen, Jiwaji, Zoeb, Baxter, Paul, Todd, Alison C, Heron, Samuel, Márkus, Nóra M, McQueen, Jamie, Hampton, David W, Torvell, Megan, Tiwari, Sachin S, McKay, Sean, Eraso-Pichot, Abel, Zorzano, Antonio, Masgrau, Roser, Galea, Elena, Chandran, Siddharthan, Wyllie, David J A, Simpson, T Ian, Hardingham, Giles E

“…This corrects the article DOI: 10.1038/ncomms15132…”
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Correction: Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism by Hasel, Philip, Dando, Owen, Jiwaji, Zoeb, Baxter, Paul, Todd, Alison C., Heron, Samuel, Márkus, Nóra M., McQueen, Jamie, Hampton, David W., Torvell, Megan, Tiwari, Sachin S., McKay, Sean, Eraso-Pichot, Abel, Zorzano, Antonio, Masgrau, Roser, Galea, Elena, Chandran, Siddharthan, Wyllie, David J. A., Simpson, T. Ian, Hardingham, Giles E.

“…Nature Communications 8: Article number: 15132 (2017); Published: 2 May 2017; Updated: 6 February 2018 Michel Goedert, who developed the Thy1-P301S transgenic…”
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An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss by Hampton, David W, Anderson, Jane, Pryce, Gareth, Irvine, Karen-Amanda, Giovannoni, Gavin, Fawcett, James W, Compston, Alastair, Franklin, Robin J.M, Baker, David, Chandran, Siddharthan

“…Abstract Multiple sclerosis (MS) represents a considerable challenge to experimentally model due to its twin pathologies of inflammatory demyelination and…”
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Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis by Hampton, David W, Serio, Andrea, Pryce, Gareth, Al-Izki, Sarah, Franklin, Robin Jm, Giovannoni, Gavin, Baker, David, Chandran, Siddharthan

“…[corrected] Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the…”
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Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system by Strappe, Padraig M., Hampton, David W., Cachon-Gonzalez, Begona, Fawcett, James W., Lever, Andrew

“…Lentiviral vectors have been demonstrated as efficient tools for gene delivery to the CNS. We describe a novel approach for vector delivery using the…”
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Spinally upregulated noggin suppresses axonal and dendritic plasticity following dorsal rhizotomy by Hampton, David W., Steeves, John D., Fawcett, James W., Ramer, Matt S.

“…Bone morphogenetic proteins (BMPs) and their antagonists, including noggin, are required for nervous system development, but their potential roles in the…”
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Cell-mediated Neuroprotection in P301S Human Tau Transgenic Mice, a Model of Human Tauopathy by Hampton, David W, Webber, Daniel J, Bilican, Bilada, Goedert, Michel, Spillantini, Maria Grazia, Chandran, Siddharthan

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Role of Ca2+-permeable non-NMDA glutamate receptors in spinal nociceptive transmission by Stanfa, Louise C, Hampton, David W, Dickenson, Anthony H

“…The functional role of Ca-permeable non-NMDA receptors in spinal nociceptive processing was investigated using joro spider toxin (JSTx), a selective blocker of…”
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O4‐03‐08: Cell‐mediated Neuroprotection in P301S Human Tau Transgenic Mice, a Model of Human Tauopathy by Hampton, David W., Webber, Daniel J., Bilican, Bilada, Goedert, Michel, Spillantini, Maria Grazia, Chandran, Siddharthan

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