Search Results - "Hampson, L"

Defining consensus opinion to develop randomised controlled trials in rare diseases using Bayesian design: An example of a proposed trial of adalimumab versus pamidronate for children with CNO/CRMO by Ramanan, A V, Hampson, L V, Lythgoe, H, Jones, A P, Hardwick, B, Hind, H, Jacobs, B, Vasileiou, D, Wadsworth, I, Ambrose, N, Davidson, J, Ferguson, P J, Herlin, T, Kavirayani, A, Killeen, O G, Compeyrot-Lacassagne, S, Laxer, R M, Roderick, M, Swart, J F, Hedrich, C M, Beresford, M W

“…Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory bone disorder primarily affecting children and adolescents. It can lead to chronic pain,…”
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"Threshold-crossing": A Useful Way to Establish the Counterfactual in Clinical Trials? by Eichler, H-G, Bloechl-Daum, B, Bauer, P, Bretz, F, Brown, J, Hampson, LV, Honig, P, Krams, M, Leufkens, H, Lim, R, Lumpkin, MM, Murphy, MJ, Pignatti, F, Posch, M, Schneeweiss, S, Trusheim, M, Koenig, F

“…A central question in the assessment of benefit/harm of new treatments is: how does the average outcome on the new treatment (the factual) compare to the…”
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Impact of Stress Urinary Incontinence after Radical Prostatectomy on Time to Intervention, Quality of Life and Work Status by Braun, A, Washington, SL, Cowan, JE, Hampson, LA, Carroll, PR

“…To characterize the incidence of stress urinary incontinence (SUI) after radical prostatectomy (RP), its treatment, and impact on quality of life (QoL) and…”
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Association Between Common Urologic Medications and Onset of Alzheimer's Disease and Related Dementias in Men With Prostate Cancer Managed by Different Primary Treatment Modalities by Braun, A E, Cowan, J E, Hampson, L A, Broering, J M, Suskind, A M, Carroll, P R

“…To understand the relationship between common urologic medications phosphodiesterase-5 inhibitors (PDE5i) and anticholinergics (AC) and risk of dementia onset…”
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The role of HPV type in Recurrent Respiratory Papillomatosis by Donne, A.J, Hampson, L, Homer, J.J, Hampson, I.N

“…Abstract Objective Human Papillomavirus (HPV) 6 and 11 are the aetiological agents responsible for Recurrent Respiratory Papillomatosis (RRP). There is general…”
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Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs by Hampson, L. J, Mackin, P, Agius, L

“…Aims/hypothesis Intraportal infusion of serotonin (5-hydroxytryptamine, 5-HT) or inhibitors of its cellular uptake stimulate hepatic glucose uptake in vivo by…”
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Effects of quinolinic acid-induced lesions of the nucleus accumbens core on inter-temporal choice : a quantitative analysis by BEZZINA, G, CHEUNG, T. H. C, ASGARI, K, HAMPSON, C. L, BODY, S, BRADSHAW, C. M, SZABADI, E, DEAKIN, J. F. W, ANDERSON, I. M

“…There is evidence that lesions of the nucleus accumbens core (AcbC) promote preference for smaller earlier reinforcers over larger delayed reinforcers in…”
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The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42 by Oliver, A W, He, X, Borthwick, K, Donne, A J, Hampson, L, Hampson, I N

“…Background: Guanidine exchange factor (GEF)-catalysed activation of Rho proteins such as Cdc42 has been shown to have a crucial role in cellular…”
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A proposal for a new PhD level curriculum on quantitative methods for drug development by Jaki, T., Gordon, A., Forster, P., Bijnens, L., Bornkamp, B., Brannath, W., Fontana, R., Gasparini, M., Hampson, L.V., Jacobs, T., Jones, B., Paoletti, X., Posch, M., Titman, A., Vonk, R., Koenig, F.

“…This paper provides an overview of “Improving Design, Evaluation and Analysis of early drug development Studies” (IDEAS), a European Commission–funded network…”
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Long-term follow-up of urethral reconstruction for blunt urethral injury at a young age: urinary and sexual quality of life outcomes by Baradaran, N., McAninch, J.W., Copp, H.L., Quanstrom, K., Breyer, B.N., Hampson, L.A.

“…Little is known about long-term patient-reported outcomes following surgical repair for pediatric blunt urethral trauma. The purpose was to evaluate long-term…”
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Effects of lesions of the nucleus accumbens core on inter-temporal choice: Further observations with an adjusting-delay procedure by da Costa Araújo, S., Body, S., Hampson, C.L., Langley, R.W., Deakin, J.F.W., Anderson, I.M., Bradshaw, C.M., Szabadi, E.

“…Previous experiments using progressive-delay schedules showed that destruction of the nucleus accumbens core (AcbC) altered rats’ choice between food…”
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role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes by Aiston, S, Hampson, L. J, Arden, C, Iynedjian, P. B, Agius, L

“…Aims/hypothesis An insulin signalling pathway leading from activation of protein kinase B (PKB, also known as Akt) to phosphorylation (inactivation) of…”
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Clinical versus economic interpretations of RCT results - Mixed messages? by McKell-Redwood, D, Hampson, L, Metcalfe, C, Noble, S, Hollingworth, W

“…Background For randomised controlled trials (RCT), the sample size needed to detect an important effect on clinical outcome is commonly believed to be…”
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Effect of disconnecting the orbital prefrontal cortex from the nucleus accumbens core on inter-temporal choice behaviour: A quantitative analysis by Bezzina, G., Body, S., Cheung, T.H.C., Hampson, C.L., Bradshaw, C.M., Szabadi, E., Anderson, I.M., Deakin, J.F.W.

“…Previous experiments showed that destruction of the orbital prefrontal cortex (OPFC) or the nucleus accumbens core (AcbC) in rats altered choice between two…”
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Effect of quinolinic acid-induced lesions of the nucleus accumbens core on performance on a progressive ratio schedule of reinforcement: implications for inter-temporal choice by Bezzina, G., Body, S., Cheung, T. H. C., Hampson, C. L., Deakin, J. F. W., Anderson, I. M., Szabadi, E., Bradshaw, C. M.

“…Rationale The nucleus accumbens core (AcbC) is believed to contribute to the control of operant behaviour by reinforcers. Recent evidence suggests that it is…”
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Effect of quinolinic acid-induced lesions of the subthalamic nucleus on performance on a progressive-ratio schedule of reinforcement: A quantitative analysis by Bezzina, G., Boon, F.S. den, Hampson, C.L., Cheung, T.H.C., Body, S., Bradshaw, C.M., Szabadi, E., Anderson, I.M., Deakin, J.F.W.

“…The subthalamic nucleus (STN), a major relay in the indirect striatofugal pathway, plays an important role in extrapyramidal motor control. Recent evidence…”
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Attenuation of the effects of d-amphetamine on interval timing behavior by central 5-hydroxytryptamine depletion by Body, S., Cheung, T. H. C., Hampson, C. L., den Boon, F. S., Bezzina, G., Fone, K. C. F., Bradshaw, C. M., Szabadi, E.

“…Rationale Interval timing in the free-operant psychophysical procedure is sensitive to the monoamine-releasing agent d -amphetamine, the D 2 -like dopamine…”
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Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies by Hampson, L, He, X T, Oliver, A W, Hadfield, J A, Kemp, T, Butler, J, McGown, A, Kitchener, H C, Hampson, I N

“…Background: Constitutive activation of RhoA-dependent RhoA kinase (ROCK) signalling is known to promote cellular transformation and the ROCK inhibitor Y-27632…”
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Effects of amisulpride and aripiprazole on progressive-ratio schedule performance: comparison with clozapine and haloperidol by den Boon, FS, Body, S, Hampson, CL, Bradshaw, CM, Szabadi, E, de Bruin, N

“…Clozapine and some other atypical antipsychotics (e.g. quetiapine, olanzapine) have been found to exert a characteristic profile of action on operant behaviour…”
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Evidence for the sensitivity of operant timing behaviour to stimulation of D1 dopamine receptors by CHEUNG, T. H. C, BEZZINA, G, HAMPSON, C. L, BODY, S, FONE, K. C. F, BRADSHAW, C. M, SZABADI, E

“…Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Previous studies using the fixed-interval peak procedure implicated…”
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