Search Results - "Hampel, Harald"

Developing the ATX(N) classification for use across the Alzheimer disease continuum by Hampel, Harald, Cummings, Jeffrey, Blennow, Kaj, Gao, Peng, Jack, Clifford R., Vergallo, Andrea

“…Breakthroughs in the development of highly accurate fluid and neuroimaging biomarkers have catalysed the conceptual transformation of Alzheimer disease (AD)…”
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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease by Blennow, Kaj, Hampel, Harald, Zetterberg, Henrik, Weiner, Michael

“…The early detection of Alzheimer disease might be critical to the effectiveness of disease-modifying drugs, when such therapies become available. In this…”
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The Amyloid-β Pathway in Alzheimer’s Disease by Hampel, Harald, Hardy, John, Blennow, Kaj, Chen, Christopher, Perry, George, Kim, Seung Hyun, Villemagne, Victor L., Aisen, Paul, Vendruscolo, Michele, Iwatsubo, Takeshi, Masters, Colin L., Cho, Min, Lannfelt, Lars, Cummings, Jeffrey L., Vergallo, Andrea

“…Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology. While the detailed…”
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The cholinergic system in the pathophysiology and treatment of Alzheimer's disease by Hampel, Harald, Mesulam, M.-Marsel, Cuello, A Claudio, Farlow, Martin R, Giacobini, Ezio, Grossberg, George T, Khachaturian, Ara S, Vergallo, Andrea, Cavedo, Enrica, Snyder, Peter J, Khachaturian, Zaven S

“…Hampel et al. review the role of the cholinergic system in cognition and how cholinergic deficits in Alzheimer's disease interact with other aspects of disease…”
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Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic by Hampel, Harald, O’Bryant, Sid E., Molinuevo, José L., Zetterberg, Henrik, Masters, Colin L., Lista, Simone, Kiddle, Steven J., Batrla, Richard, Blennow, Kaj

“…Biomarker discovery and development for clinical research, diagnostics and therapy monitoring in clinical trials have advanced rapidly in key areas of medicine…”
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Blood-based biomarkers for Alzheimer’s disease: Current state and future use in a transformed global healthcare landscape by Hampel, Harald, Hu, Yan, Cummings, Jeffrey, Mattke, Soeren, Iwatsubo, Takeshi, Nakamura, Akinori, Vellas, Bruno, O’Bryant, Sid, Shaw, Leslie M., Cho, Min, Batrla, Richard, Vergallo, Andrea, Blennow, Kaj, Dage, Jeffrey, Schindler, Suzanne E.

“…Timely detection of the pathophysiological changes and cognitive impairment caused by Alzheimer’s disease (AD) is increasingly pressing because of the advent…”
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Blood and plasma-based proteomic biomarker research in Alzheimer's disease by Lista, Simone, Faltraco, Frank, Prvulovic, David, Hampel, Harald

“…Alzheimer's disease (AD) is the most important cause of dementia in the elderly. The molecular alterations preceding this neurodegenerative pathology may take…”
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Current state of Alzheimer’s fluid biomarkers by Molinuevo, José Luis, Ayton, Scott, Batrla, Richard, Bednar, Martin M., Bittner, Tobias, Cummings, Jeffrey, Fagan, Anne M., Hampel, Harald, Mielke, Michelle M., Mikulskis, Alvydas, O’Bryant, Sid, Scheltens, Philip, Sevigny, Jeffrey, Shaw, Leslie M., Soares, Holly D., Tong, Gary, Trojanowski, John Q., Zetterberg, Henrik, Blennow, Kaj

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number of people living with AD is…”
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Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia by Ewers, Michael, Sperling, Reisa A, Klunk, William E, Weiner, Michael W, Hampel, Harald

“…Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. At the time of clinical manifestation of dementia, significant irreversible…”
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Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease by Blennow, Kaj, Dubois, Bruno, Fagan, Anne M, Lewczuk, Piotr, de Leon, Mony J, Hampel, Harald

“…Abstract Several potential disease-modifying drugs for Alzheimer's disease (AD) have failed to show any effect on disease progression in clinical trials,…”
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A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease by Hampel, Harald, Caraci, Filippo, Cuello, A Claudio, Caruso, Giuseppe, Nisticò, Robert, Corbo, Massimo, Baldacci, Filippo, Toschi, Nicola, Garaci, Francesco, Chiesa, Patrizia A, Verdooner, Steven R, Akman-Anderson, Leyla, Hernández, Félix, Ávila, Jesús, Emanuele, Enzo, Valenzuela, Pedro L, Lucía, Alejandro, Watling, Mark, Imbimbo, Bruno P, Vergallo, Andrea, Lista, Simone

“…Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and represents one of the earliest pathomechanistic alterations throughout…”
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Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria by Dubois, Bruno, Hampel, Harald, Feldman, Howard H, Scheltens, Philip, Aisen, Paul, Andrieu, Sandrine, Bakardjian, Hovagim, Benali, Habib, Bertram, Lars, Blennow, Kaj, Broich, Karl, Cavedo, Enrica, Crutch, Sebastian, Dartigues, Jean-François, Duyckaerts, Charles, Epelbaum, Stéphane, Frisoni, Giovanni B, Gauthier, Serge, Genthon, Remy, Gouw, Alida A, Habert, Marie-Odile, Holtzman, David M, Kivipelto, Miia, Lista, Simone, Molinuevo, José-Luis, O'Bryant, Sid E, Rabinovici, Gil D, Rowe, Christopher, Salloway, Stephen, Schneider, Lon S, Sperling, Reisa, Teichmann, Marc, Carrillo, Maria C, Cummings, Jeffrey, Jack, Cliff R

“…Abstract During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to…”
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Implementation of subjective cognitive decline criteria in research studies by Molinuevo, José L, Rabin, Laura A, Amariglio, Rebecca, Buckley, Rachel, Dubois, Bruno, Ellis, Kathryn A, Ewers, Michael, Hampel, Harald, Klöppel, Stefan, Rami, Lorena, Reisberg, Barry, Saykin, Andrew J, Sikkes, Sietske, Smart, Colette M, Snitz, Beth E, Sperling, Reisa, van der Flier, Wiesje M, Wagner, Michael, Jessen, Frank

“…Abstract Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention…”
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microRNA-Based Biomarkers in Alzheimer's Disease (AD) by Zhao, Yuhai, Jaber, Vivian, Alexandrov, Peter N, Vergallo, Andrea, Lista, Simone, Hampel, Harald, Lukiw, Walter J

“…Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized by complex pathophysiological dynamics taking place at multiple…”
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Relevance of Magnetic Resonance Imaging for Early Detection and Diagnosis of Alzheimer Disease by Teipel, Stefan J., MD, Grothe, Michel, PhD, Lista, Simone, PhD, Toschi, Nicola, PhD, Garaci, Francesco G., PhD, Hampel, Harald, MD

“…Magnetic resonance imaging (MRI)-based indicators of regional and global brain atrophy and more advanced measures of cortical functional and structural…”
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Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis by Matsunaga, Shinji, Kishi, Taro, Annas, Peter, Basun, Hans, Hampel, Harald, Iwata, Nakao

“…This is the first meta-analysis of randomized placebo-controlled trials testing lithium as a treatment for patients with Alzheimer's disease (AD) and…”
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Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage by Vos, Stephanie J. B., Verhey, Frans, Frölich, Lutz, Kornhuber, Johannes, Wiltfang, Jens, Maier, Wolfgang, Peters, Oliver, Rüther, Eckart, Nobili, Flavio, Morbelli, Silvia, Frisoni, Giovanni B., Drzezga, Alexander, Didic, Mira, van Berckel, Bart N. M., Simmons, Andrew, Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Lovestone, Simon, Muscio, Cristina, Herukka, Sanna-Kaisa, Salmon, Eric, Bastin, Christine, Wallin, Anders, Nordlund, Arto, de Mendonça, Alexandre, Silva, Dina, Santana, Isabel, Lemos, Raquel, Engelborghs, Sebastiaan, Van der Mussele, Stefan, Freund-Levi, Yvonne, Wallin, Åsa K., Hampel, Harald, van der Flier, Wiesje, Scheltens, Philip, Visser, Pieter Jelle

“…© The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email:…”
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Revising the definition of Alzheimer's disease: a new lexicon by Dubois, Bruno, Prof, Feldman, Howard H, Prof, Jacova, Claudia, PhD, Cummings, Jeffrey L, MD, DeKosky, Steven T, Prof, Barberger-Gateau, Pascale, MD, Delacourte, André, PhD, Frisoni, Giovanni, Prof, Fox, Nick C, Prof, Galasko, Douglas, Prof, Gauthier, Serge, Prof, Hampel, Harald, Prof, Jicha, Gregory A, MD, Meguro, Kenichi, MD, O'Brien, John, DM, Pasquier, Florence, Prof, Robert, Philippe, Prof, Rossor, Martin, Prof, Salloway, Steven, Prof, Sarazin, Marie, MD, de Souza, Leonardo C, MD, Stern, Yaakov, Prof, Visser, Pieter J, MD, Scheltens, Philip, Prof

“…Summary Alzheimer's disease (AD) is classically defined as a dual clinicopathological entity. The recent advances in use of reliable biomarkers of AD that…”
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Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study by O'Dwyer, Laurence, Lamberton, Franck, Matura, Silke, Tanner, Colby, Scheibe, Monika, Miller, Julia, Rujescu, Dan, Prvulovic, David, Hampel, Harald

“…The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer's disease (AD). The E4 allele is also associated…”
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Total and phosphorylated tau protein as biological markers of Alzheimer’s disease by Hampel, Harald, Blennow, Kaj, Shaw, Leslie M., Hoessler, Yvonne C., Zetterberg, Henrik, Trojanowski, John Q.

“…Advances in our understanding of tau-mediated neurodegeneration in Alzheimer’s disease (AD) are moving this disease pathway to center stage for the development…”
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