Search Results - "Hamonic, Glenn"

Immune responses in the uterine mucosa: clues for vaccine development in pigs by Choudhary, Pooja, Magloire, Donaldson, Hamonic, Glenn, Wilson, Heather L

“…The immune system in the upper reproductive tract (URT) protects against sexually transmitted pathogens, while at the same time providing immune tolerance…”
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A DIO2 missense mutation and its impact on fetal response to PRRSV infection by Ko, Haesu, Pasternak, J Alex, Mulligan, Margaret K, Hamonic, Glenn, Ramesh, Naresh, MacPhee, Daniel J, Plastow, Graham S, Harding, John C S

“…Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) infection during late gestation substantially lowers fetal viability and survival. In a…”
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Expression of pattern recognition receptors in porcine uterine epithelial cells in vivo and in culture by Hamonic, Glenn, Pasternak, J. Alex, Forsberg, Nikki M., Käser, Tobias, Wilson, Heather L.

“…•A number of pattern recognition receptors are expressed by porcine uterine epithelial cells.•TLR3 and TLR9 localize to the apical cell membrane and TLR4…”
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Genome wide association study of thyroid hormone levels following challenge with porcine reproductive and respiratory syndrome virus by Van Goor, Angelica, Pasternak, Alex, Walugembe, Muhammed, Chehab, Nadya, Hamonic, Glenn, Dekkers, Jack C M, Harding, John C S, Lunney, Joan K

“…Porcine reproductive and respiratory syndrome virus (PRRSV) causes respiratory disease in piglets and reproductive disease in sows. Piglet and fetal serum…”
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Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection by Malgarin, Carolina M, Moser, Fiona, Pasternak, J Alex, Hamonic, Glenn, Detmer, Susan E, MacPhee, Daniel J, Harding, John C S

“…Mechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or placental detachment…”
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Assessment of Immunological Response and Impacts on Fertility Following Intrauterine Vaccination Delivered to Swine in an Artificial Insemination Dose by Hamonic, Glenn, Pasternak, J Alex, Ng, Siew Hon, Fourie, Kezia R, Simko, Olena M, Deluco, Brodie, Wilson, Heather L

“…To protect the health of sows and gilts, significant investments are directed toward the development of vaccines against infectious agents that impact…”
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Molecular and Physiological Effects on the Small Intestine of Weaner Pigs Following Feeding with Deoxynivalenol-Contaminated Feed by Pasternak, J Alex, Aiyer, Vaishnavi Iyer Aka, Hamonic, Glenn, Beaulieu, A Denise, Columbus, Daniel A, Wilson, Heather L

“…We intended to assess how exposure of piglets to deoxynivalenol (DON)-contaminated feed impacted their growth, immune response and gut development. Piglets…”
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The Adjuvants Polyphosphazene (PCEP) and a Combination of Curdlan Plus Leptin Promote a Th17-Type Immune Response to an Intramuscular Vaccine in Mice by Chaffey, Alyssa, Hamonic, Glenn, Chand, Dylan, Mutwiri, George K., Wilson, Heather L.

“…Our aim was to determine whether polyphosphazene (PCEP), Curdlan (β-glucan, a dectin-1 agonist), and Leptin could act as adjuvants to promote a Th17-type…”
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Postnatal regulation of MAMDC4 in the porcine intestinal epithelium is influenced by bacterial colonization by Pasternak, Alex J., Hamonic, Glenn M., Van Kessel, Andrew, Wilson, Heather L.

“…The MAM domain‐containing 4 (MAMDC4) protein is associated with the unique endocytotic mechanism observed in the intestine of mammals during the immediate…”
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Postnatal regulation of MAMDC 4 in the porcine intestinal epithelium is influenced by bacterial colonization by Pasternak, Alex J., Hamonic, Glenn M., Van Kessel, Andrew, Wilson, Heather L.

“…Abstract The MAM domain‐containing 4 ( MAMDC 4) protein is associated with the unique endocytotic mechanism observed in the intestine of mammals during the…”
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Recognizing conserved non-canonical localization patterns of toll-like receptors in tissues and across species by Hamonic, Glenn, Pasternak, J. Alex, Wilson, Heather L.

“…Toll-like receptors (TLR) 1, 2, 4, 5 and 6 were originally characterized as exclusively expressed on the cell surface and TLR 3, 7, 8 and 9 were said to be…”
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Complex immunogenomic control of serum thyroid hormone levels in fetuses and piglets challenged with Porcine Reproductive and Respiratory Syndrome Virus by Van Goor, Angelica G, Pasternak, Alex, Walugembe, Muhammed, Hamonic, Glenn, Dekkers, Jack, Harding, John C. S., Lunney, Joan K

“…Abstract Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) causes respiratory disease in piglets and reproductive disease in sows. However, the…”
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Phenotypic effect of a single nucleotide polymorphism on SSC7 on fetal outcomes in PRRSV-2 infected gilts by Ko, Haesu, Sammons, Jourdyn, Pasternak, J. Alex, Hamonic, Glenn, Starrak, Gregory, MacPhee, Daniel J., Detmer, Susan E., Plastow, Graham S., Harding, John C.S.

“…•A single nucleotide polymorphism near the iodothyronine deiodinase 2 (DIO2) gene in fetal pigs was associated with variation in serum total T4 level and size…”
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Dual infections of CD163 expressing NPTr epithelial cells with influenza A virus and PRRSV by Provost, Chantale, Hamonic, Glenn, Gagnon, Carl A., Meurens, François

“…•An epithelial cell line expressing, CD163, the main receptor of PRRSV was generated.•swIAV as well as PRRSV interfere with each other.•PRRSV impacted the…”
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Effect of porcine reproductive and respiratory syndrome virus 2 on tight junction gene expression at the maternal-fetal interface by Guidoni, Pauline B., Pasternak, J. Alex, Hamonic, Glenn, MacPhee, Daniel J., Harding, John C.S.

“…Understanding why intrauterine growth restricted (IUGR) fetuses are more resilient to transplacental porcine reproductive and respiratory syndrome virus-2…”
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Decreased tight junction protein intensity in the placenta of porcine reproductive and respiratory syndrome virus-2 infected fetuses by Guidoni, Pauline B., Pasternak, Jonathan A., Hamonic, Glenn, MacPhee, Daniel J., Harding, John C.S.

“…Existing strategies to control porcine reproductive and respiratory syndrome (PRRS) are not completely effective and require alternative approaches. Although…”
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Efficacy of a stable broadly protective subunit vaccine platform against SARS-CoV-2 variants of concern by Garg, Ravendra, Liu, Qiang, Van Kessel, Jill, Asavajaru, Akarin, Uhlemann, Eva-Maria, Joessel, Morgane, Hamonic, Glenn, Khatooni, Zahed, Kroeker, Andrea, Lew, Jocelyne, Scruten, Erin, Pennington, Paul, Deck, William, Prysliak, Tracy, Nickol, Michaela, Apel, Falko, Courant, Thomas, Kelvin, Alyson A., Van Kessel, Andrew, Collin, Nicolas, Gerdts, Volker, Köster, Wolfgang, Falzarano, Darryl, Racine, Trina, Banerjee, Arinjay

“…The emergence and ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the need for rapid vaccine development…”
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Effect of porcine reproductive and respiratory syndrome virus 2 on angiogenesis and cell proliferation at the maternal-fetal interface by Barrera-Zarate, Javier A., Detmer, Susan E., Pasternak, J. Alex, Hamonic, Glenn, MacPhee, Daniel J., Harding, John C. S.

“…Angiogenesis and cell proliferation in reproductive tissues are essential events for the maintenance of pregnancy, and alterations can lead to compromised…”
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Detection of PRRSV-2 alone and co-localized with CD163 positive macrophages in porcine placental areolae by Barrera-Zarate, Javier, Detmer, Susan E., Pasternak, J. Alex, Hamonic, Glenn, MacPhee, Daniel J., Harding, John C.S.

“…The porcine epitheliochorial placenta creates a barrier for the transplacental transfer of some nutrients from the dam to the fetus, as well as feto-lethal…”
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Intrauterine delivery of subunit vaccines induces a systemic and mucosal immune response in rabbits by Pasternak, Jonathan Alexander, Hamonic, Glenn, Forsberg, Nikki M., Wheler, Colette L., Dyck, Michael K., Wilson, Heather L.

“…Problem Mucosal vaccines have long been sought after to improve protection though the production of both a mucosal and systemic immune response, and are…”
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