Search Results - "Hammonds, Timothy R"

Antitumor Polycyclic Acridines. 7. Synthesis and Biological Properties of DNA Affinic Tetra- and Pentacyclic Acridines by Stanslas, Johnson, Hagan, Damien J, Ellis, Michael J, Turner, Claire, Carmichael, James, Ward, Wynne, Hammonds, Timothy R, Stevens, Malcolm F. G

“…New synthetic routes to a series of tetra- and pentacyclic acridines related in structure to marine natural products are reported. The novel water-soluble…”
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Use of a Rapid Throughput In Vivo Screen To Investigate Inhibitors of Eukaryotic Topoisomerase II Enzymes by HAMMONDS, T. R, MAXWELL, A, JENKINS, J. R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The N-Terminal Domain of Human Topoisomerase IIα Is a DNA-Dependent ATPase by Gardiner, Laurence P, Roper, David I, Hammonds, Timothy R, Maxwell, Anthony

“…We have constructed clones encoding N-terminal fragments of human DNA topoisomerase IIα. We show that the N-terminal domain (∼50 kDa) has an intrinsic ATPase…”
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The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase IIα by Hammonds, Timothy R., Maxwell, Anthony

“…We have purified human topoisomerase IIα from HeLa cells and studied its ATPase reaction. The ATPase activity is stimulated by DNA and shows apparent…”
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The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase IIÎ by Timothy R. Hammonds, Anthony Maxwell

“…We have purified human topoisomerase IIα from HeLa cells and studied its ATPase reaction. The ATPase activity is stimulated by DNA and shows apparent…”
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Increased sensitivity to quinolone antibacterials can be engineered in human topoisomerase IIα by selective mutagenesis by Hammonds, Timothy R, Foster, Simon R, Maxwell, Anthony

“…A potential region of drug-DNA interaction in the A subunit of DNA gyrase has previously been identified from crystallographic studies. The local amino acid…”
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