Search Results - "Hammond, Victoria J."

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease by Uderhardt, Stefan, Ackermann, Jochen A, Fillep, Tobias, Hammond, Victoria J, Willeit, Johann, Santer, Peter, Mayr, Manuel, Biburger, Markus, Miller, Meike, Zellner, Katie R, Stark, Konstantin, Zarbock, Alexander, Rossaint, Jan, Schubert, Irene, Mielenz, Dirk, Dietel, Barbara, Raaz-Schrauder, Dorette, Ay, Cihan, Gremmel, Thomas, Thaler, Johannes, Heim, Christian, Herrmann, Martin, Collins, Peter W, Schabbauer, Gernot, Mackman, Nigel, Voehringer, David, Nadler, Jerry L, Lee, James J, Massberg, Steffen, Rauh, Manfred, Kiechl, Stefan, Schett, Georg, O'Donnell, Valerie B, Krönke, Gerhard

“…Blood coagulation is essential for physiological hemostasis but simultaneously contributes to thrombotic disease. However, molecular and cellular events…”
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Esterified eicosanoids: Generation, characterization and function by Hammond, Victoria J., O'Donnell, Valerie B.

“…Eicosanoids are oxidation products of C20 polyunsaturated fatty acids (e.g. arachidonic acid) that include prostaglandins, thromboxanes, leukotrienes and…”
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Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation by Clark, Stephen R., Thomas, Christopher P., Hammond, Victoria J., Aldrovandi, Maceler, Wilkinson, Gavin W., Hart, Keith W., Murphy, Robert C., Collins, Peter W., O'Donnell, Valerie B.

“…Aminophospholipid (APL) trafficking across the plasma membrane is a key event in cell activation, apoptosis, and aging and is required for clearance of dying…”
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Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation[S] by Aldrovandi, Maceler, Hammond, Victoria J., Podmore, Helen, Hornshaw, Martin, Clark, Stephen R., Marnett, Lawrence J., Slatter, David A., Murphy, Robert C., Collins, Peter W., O'Donnell, Valerie B.

“…Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in inflammation. Their generation by cellular cyclooxygenases…”
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Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation by Fielding, Ceri A., Jones, Gareth W., McLoughlin, Rachel M., McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen S., Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal S., Hams, Emily, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John D., Williams, Geraint T., Davies, Simon J., Humphreys, Ian R., O’Donnell, Valerie B., Taylor, Philip R., Jenkins, Brendan J., Topley, Nicholas, Jones, Simon A.

“…Fibrosis in response to tissue damage or persistent inflammation is a pathological hallmark of many chronic degenerative diseases. By using a model of acute…”
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Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection by Clark, Stephen R., Guy, Christopher J., Scurr, Martin J., Taylor, Philip R, Kift-Morgan, Ann P., Hammond, Victoria J., Thomas, Christopher P., Coles, Barbara, Roberts, Gareth W., Eberl, Matthias, Jones, Simon A., Topley, Nicholas, Kotecha, Sailesh, O'Donnell, Valerie B.

“…5-Lipoxygenase (5-LOX) plays key roles in infection and allergic responses. Herein, four 5-LOX–derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE)…”
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AMPA receptor activation promotes non-amyloidogenic amyloid precursor protein processing and suppresses neuronal amyloid-β production by Hoey, Sarah E, Buonocore, Federica, Cox, Carla J, Hammond, Victoria J, Perkinton, Michael S, Williams, Robert J

“…Soluble oligomeric amyloid β peptide (Aβ) generated from processing of the amyloid precursor protein (APP) plays a central role in the pathogenesis of…”
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A novel role for 12/15-lipoxygenase in regulating autophagy by Morgan, Alwena H, Hammond, Victoria J, Sakoh-Nakatogawa, Machiko, Ohsumi, Yoshinori, Thomas, Christopher P, Blanchet, Fabien, Piguet, Vincent, Kiselyov, Kirill, O'Donnell, Valerie B

“…12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain…”
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice by Friedmann Angeli, Jose Pedro, Schneider, Manuela, Proneth, Bettina, Tyurina, Yulia Y., Tyurin, Vladimir A., Hammond, Victoria J., Herbach, Nadja, Aichler, Michaela, Walch, Axel, Eggenhofer, Elke, Basavarajappa, Devaraj, Rådmark, Olof, Kobayashi, Sho, Seibt, Tobias, Beck, Heike, Neff, Frauke, Esposito, Irene, Wanke, Rüdiger, Förster, Heidi, Yefremova, Olena, Heinrichmeyer, Marc, Bornkamm, Georg W., Geissler, Edward K., Thomas, Stephen B., Stockwell, Brent R., O’Donnell, Valerie B., Kagan, Valerian E., Schick, Joel A., Conrad, Marcus

“…Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells overexpressing oncogenic RAS…”
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Loss of CD4+ T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells by Jones, Gareth W, McLoughlin, Rachel M, Hammond, Victoria J, Parker, Clare R, Williams, John D, Malhotra, Raj, Scheller, Jurgen, Williams, Anwen S, Rose-John, Stefan, Topley, Nicholas, Jones, Simon A

“…IL-6 responses are classically orchestrated via a membrane-bound IL-6R (CD126) alpha subunit (classical IL-6R signaling) or through a soluble form of this…”
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Novel Keto-phospholipids Are Generated by Monocytes and Macrophages, Detected in Cystic Fibrosis, and Activate Peroxisome Proliferator-activated Receptor-γ by Hammond, Victoria J., Morgan, Alwena H., Lauder, Sarah, Thomas, Christopher P., Brown, Sarah, Freeman, Bruce A., Lloyd, Clare M., Davies, Jane, Bush, Andrew, Levonen, Anna-Liisa, Kansanen, Emilia, Villacorta, Luis, Chen, Y.Eugene, Porter, Ned, Garcia-Diaz, Yoel M., Schopfer, Francisco J., O'Donnell, Valerie B.

“…12/15-Lipoxygenases (LOXs) in monocytes and macrophages generate novel phospholipid-esterified eicosanoids. Here, we report the generation of two additional…”
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Contribution of Individual Histidines to Prion Protein Copper Binding by Davies, Paul, McHugh, Patrick C, Hammond, Victoria J, Marken, Frank, Brown, David R

“…The prion protein is well-established as a copper binding protein. The N-terminus of the protein contains an octameric repeat region with each of the four…”
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Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells by Thomas, Christopher P, Clark, Stephen R, Hammond, Victoria J, Aldrovandi, Maceler, Collins, Peter W, O'Donnell, Valerie B

“…This protocol measures externalization of aminophospholipids (APLs) to the outside of the plasma membrane using mass spectrometry (MS). APL externalization…”
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Correction: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease by Uderhardt, Stefan, Ackermann, Jochen A, Fillep, Tobias, Hammond, Victoria J, Willeit, Johann, Santer, Peter, Mayr, Manuel, Biburger, Markus, Miller, Meike, Zellner, Katie R, Stark, Konstantin, Zarbock, Alexander, Rossaint, Jan, Schubert, Irene, Mielenz, Dirk, Dietel, Barbara, Raaz-Schrauder, Dorette, Ay, Cihan, Gremmel, Thomas, Thaler, Johannes, Heim, Christian, Herrmann, Martin, Collins, Peter W, Schabbauer, Gernot, Mackman, Nigel, Voehringer, David, Nadler, Jerry L, Lee, James J, Massberg, Steffen, Rauh, Manfred, Kiechl, Stefan, Schett, Georg, O'Donnell, Valerie B, Krönke, Gerhard

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An optical sensor for reactive oxygen species: encapsulation of functionalised silica nanoparticles into silicate nanoprobes to reduce fluorophore leaching by Hammond, Victoria J, Aylott, Jonathan W, Greenway, Gillian M, Watts, Paul, Webster, Abigail, Wiles, Charlotte

“…Sol-gel nanoprobes, also known as Photonic Explorer for Bioanalysis with Biologically Localised Embedding (PEBBLE), capable of performing in-vitro…”
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Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation by Hams, Emily, Colmont, Chantal S, Dioszeghy, Vincent, Hammond, Victoria J, Fielding, Ceri A, Williams, Anwen S, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip R, Topley, Nicholas, Jones, Simon A

“…Although the IL-6-related cytokine oncostatin M (OSM) affects processes associated with disease progression, the specific function of OSM in the face of an…”
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Quantitative assays for esterified oxylipins generated by immune cells by O'Donnell, Valerie B, Morgan, Alwena H, Hammond, Victoria J, Morgan, Lloyd, Thomas, Christopher P, Tallman, Keri A, Garcia-Diaz, Yoel R, McGuigan, Christopher, Serpi, Michaela, Porter, Ned A, Murphy, Robert C

“…Phospholipid-esterified oxylipins include newly described families of bioactive lipids generated by lipoxygenases in immune cells. Until now, assays for their…”
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Inactivation of the Ferroptosis Regulator Gpx4 Triggers Acute Renal Failure in a Therapeutically Relevant Mechanism by Angeli, Jose Pedro Friedmann, Proneth, Bettina, Hammond, Victoria J., Tyurina, Yulia Y., Tyurin, Vladimir A., O`Donnell, Valerie B., Kagan, Valerian E., Conrad, Marcus

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170 - Inactivation of the Ferroptosis Regulator Gpx4 Triggers Acute Renal Failure in a Therapeutically Relevant Mechanism by Angeli, Jose Pedro Friedmann, Proneth, Bettina, Hammond, Victoria J., Tyurina, Yulia Y., Tyurin, Vladimir A., O`Donnell, Valerie B., Kagan, Valerian E., Conrad, Marcus

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212 by Rice, Christopher M., Greenhill, Claire J., Jones, Gareth W., Aldrovandi, Maceler, Hammond, Victoria J., O’Donnell, Valerie B., Topley, Nicholas, Taylor, Philip R., Jones, Simon A.

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