Search Results - "Hammond, Philip W."

Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses by Grandea, Andres G., Olsen, Ole A., Cox, Thomas C., Renshaw, Mark, Hammond, Philip W., Chan-Hui, Po-Ying, Mitcham, Jennifer L., Cieplak, Witold, Stewart, Shaun M., Grantham, Michael L., Pekosz, Andrew, Kiso, Maki, Shinya, Kyoko, Hatta, Masato, Kawaoka, Yoshihiro, Moyle, Matthew, Chisari, Francis V.

“…Influenza remains a serious public health threat throughout the world. Vaccines and antivirals are available that can provide protection from infection…”
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A molecular immunology approach to antibody humanization and functional optimization by Lazar, Greg A., Desjarlais, John R., Jacinto, Jonathan, Karki, Sher, Hammond, Philip W.

“…We introduce a new method of humanization based on a novel and immunologically relevant metric of antibody humanness, termed human string content (HSC), that…”
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Accessing the human repertoire for broadly neutralizing HIV antibodies by Hammond, Philip W.

“…The human antibody response has special significance in the ongoing efforts to develop a protective HIV vaccine. The observation that a subset of HIV infected…”
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In Vitro Selection and Characterization of Bcl-XL-binding Proteins from a Mix of Tissue-specific mRNA Display Libraries by Hammond, Philip W., Alpin, Julia, Rise, Cecil E., Wright, Martin, Kreider, Brent L.

“…The covalent coupling of an mRNA to the protein that it encodes (mRNA display) provides a powerful tool for analysis of protein function in the post-genomic…”
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Generating addressable protein microarrays with PROfusion™ covalent mRNA-protein fusion technology by Weng, Shawn, Gu, Ke, Hammond, Philip W., Lohse, Peter, Rise, Cecil, Wagner, Richard W., Wright, Martin C., Kuimelis, Robert G.

“…An mRNA‐protein fusion consists of a polypeptide covalently linked to its corresponding mRNA. These species, prepared individually or en masse by in vitro…”
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Immobilization of acrylamide-modified oligonucleotides by co-polymerization by Rehman, Farah N., Audeh, Mark, Abrams, Ezra S., Hammond, Philip W., Kenney, Mary, Boles, T. Christian

“…A flexible chemistry for solid phase attachment of oligonucleotides is described. Oligonucleotides bearing 5′-terminal acrylamide modifications efficiently…”
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Euplotes Telomerase:  Evidence for Limited Base-Pairing during Primer Elongation and dGTP as an Effector of Translocation by Hammond, Philip W, Cech, Thomas R

“…The telomeric sequence repeats at the ends of eukaryotic chromosomes are maintained by the ribonucleoprotein enzyme telomerase. Telomeric DNA primers are bound…”
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Drug Receptor Identification from Multiple Tissues Using Cellular-Derived mRNA Display Libraries by McPherson, Michael, Yang, Yingfei, Hammond, Philip W, Kreider, Brent L

“…The use of display technologies to identify small molecule receptors from proteome libraries would provide a significant advantage in drug discovery. We have…”
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Chemical genomics: targets on display by Doberstein, Steve, Hammond, Philip W, Hubert, René S

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The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers by Hammond, Philip W., Lively, Tricia N., Cech, Thomas R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Humanized Anti-CD30 Monoclonal Antibody, XmAb™2513, with Enhanced In Vitro Potency Against CD30-Positive Lymphomas Mediated by High Affinity Fc-Receptor Binding by Hammond, Philip W., Vafa, Omid, Jacinto, Jonathan, Vielmetter, Jost, Karki, Sher, Yoder, Sean, Lazar, Greg, Raturi, Dinesh, Mollet, Mike, Zhu, Marie, Kunkel, Lori, Carmichael, David

“…CD30 (also known as Ki-1), a member of the TNF-receptor superfamily, is normally expressed at low levels on activated lymphocytes and has been implicated in…”
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dGTP-dependent processivity and possible template switching of Euplotes telomerase by Hammond, Philip W., Cech, Thomas R.

“…We have measured the processivity of telomeric DNA extension by Euplotes aediculatus telomerase at various concentrations of the nucleotide substrates dGTP and…”
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Nucleophilic addition to the 9 position of 9-phenylcarboxylate-10-methylacridinium protects against hydrolysis of the ester by Hammond, P W, Wiese, W A, Waldrop, 3rd, A A, Nelson, N C, Arnold, Jr, L J

“…The chemiluminescent reaction of an acridinium ester (AE) requires addition of peroxide to the 9 position of the acridinium ring. The addition of a hydroxide…”
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Detection of All Single-Base Mismatches in Solution by Chemiluminescence by Nelson, Norman C., Hammond, Philip W., Matsuda, Eiji, Goud, Anil A., Becker, Michael M.

“…A rapid in-solution method for the detection of all 12 single-base mismatches is described. The technique is based on the hybridization protection assay (HPA)…”
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