Search Results - "Hammond, H. Kirk"

Design of a Phase 3 trial of intracoronary administration of human adenovirus 5 encoding human adenylyl cyclase type 6 (RT-100) gene transfer in patients with heart failure with reduced left ventricular ejection fraction: The FLOURISH Clinical Trial by Penny, William F., Henry, Timothy D., Watkins, Matthew W., Patel, Amit N., Hammond, H. Kirk

“…The prognosis of patients with HFrEF remains poor despite the use of current medical and device therapies. Preclinical studies of HFrEF using IC delivery of…”
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Impact of blood factors on endothelial cell metabolism and function in two diverse heart failure models by Song, Young, Leem, Joseph, Dhanani, Mehul, McKirnan, M Dan, Ichikawa, Yasuhiro, Braza, Julie, Harrington, Elizabeth O, Hammond, H Kirk, Roth, David M, Patel, Hemal H

“…Role of blood-based factors in development and progression of heart failure (HF) is poorly characterized. Blood contains factors released during…”
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Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina by Mathur, Pranav Dinesh, Zou, Junhuang, Neiswanger, Grace, Zhu, Daniel, Wang, Yong, Almishaal, Ali A., Vashist, Deepti, Hammond, H. Kirk, Park, Albert H., Yang, Jun

“…Adenylyl cyclase 6 (AC6) synthesizes second messenger cAMP in G protein-coupled receptor (GPCR) signaling. In cochlear hair cells, AC6 distribution relies on…”
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Adenylate Cyclase 6 Determines cAMP Formation and Aquaporin-2 Phosphorylation and Trafficking in Inner Medulla by RIEG, Timo, TONG TANG, MURRAY, Fiona, SCHROTH, Jana, INSEL, Paul A, FENTON, Robert A, KIRK HAMMOND, H, VALLON, Volker

“…Arginine vasopressin (AVP) enhances water reabsorption in the renal collecting duct by vasopressin V₂ receptor (V₂R)-mediated activation of adenylyl cyclase…”
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Urocortin 2 Gene Transfer Reduces the Adverse Effects of a Western Diet on Cardiac Function in Mice by Kim, Young Chul, Giamouridis, Dimosthenis, Lai, N Chin, Guo, Tracy, Xia, Bing, Fu, Zhenxing, Gao, Mei Hua, Hammond, H Kirk

“…Diabetes mellitus is associated with increased risk of heart failure. It has been previously demonstrated in mice that a single injection of adeno-associated…”
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Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain ( C1C2 ) Attenuates Deleterious Effects of Pressure Overload by Tan, Zhen, Giamouridis, Dimosthenis, Lai, N Chin, Kim, Young Chul, Guo, Tracy, Xia, Bing, Gao, Mei Hua, Hammond, H Kirk

“…A fusion protein (C1C2) constructed by fusing the intracellular C1 and C2 segments of adenylyl cyclase type 6 (AC6) retains beneficial effects of AC6…”
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Human Oxidation-Specific Antibodies Reduce Foam Cell Formation and Atherosclerosis Progression by Tsimikas, Sotirios, MD, Miyanohara, Atsushi, PhD, Hartvigsen, Karsten, PhD, Merki, Esther, PhD, Shaw, Peter X., PhD, Chou, Meng-Yun, PhD, Pattison, Jennifer, BA, Torzewski, Michael, MD, Sollors, Janina, Friedmann, Theodore, MD, Lai, N. Chin, PhD, Hammond, H. Kirk, MD, Getz, Godfrey S., MD, PhD, Reardon, Catherine A., PhD, Li, Andrew C., MD, Banka, Carole L., PhD, Witztum, Joseph L., MD

“…Objectives We sought to assess the in vivo importance of scavenger receptor (SR)–mediated uptake of oxidized low-density lipoprotein (OxLDL) in atherogenesis…”
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Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance by Kim, Young Chul, Truax, Agnieszka D, Giamouridis, Dimosthenis, Lai, N Chin, Guo, Tracy, Hammond, H Kirk, Gao, Mei Hua

“…Urocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector…”
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Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice by Giamouridis, Dimosthenis, Gao, Mei Hua, Lai, N. Chin, Guo, Tracy, Miyanohara, Atsushi, Blankesteijn, W. Matthijs, Biessen, Erik A.L., Hammond, H. Kirk

“…Prevalence of left ventricular (LV) systolic and diastolic dysfunction increases with aging. We previously reported that urocortin 2 (Ucn2) gene transfer…”
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Reduced Collagen Deposition in Infarcted Myocardium Facilitates Induced Pluripotent Stem Cell Engraftment and Angiomyogenesis for Improvement of Left Ventricular Function by Dai, Bo, MD, PhD, Huang, Wei, MD, PhD, Xu, Meifeng, MD, PhD, Millard, Ronald W., PhD, Gao, Mei Hua, PhD, Hammond, H. Kirk, PhD, Menick, Donald R., PhD, Ashraf, Muhammad, PhD, Wang, Yigang, MD, PhD

“…Objectives The purpose of this study was to assess the effect of scar tissue composition on engraftment of progenitor cells into infarcted myocardium…”
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Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6 by Bull Melsom, Caroline, Cosson, Marie-Victoire, Ørstavik, Øivind, Lai, Ngai Chin, Hammond, H Kirk, Osnes, Jan-Bjørn, Skomedal, Tor, Nikolaev, Viacheslav, Levy, Finn Olav, Krobert, Kurt Allen

“…We previously reported that inhibitory G protein (Gi) exerts intrinsic receptor-independent inhibitory activity upon adenylyl cyclase (AC) that regulates…”
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Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation by Gao, Mei Hua, Lai, N Chin, Giamouridis, Dimosthenis, Kim, Young Chul, Guo, Tracy, Hammond, H Kirk

“…Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and…”
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Adenylyl Cyclase Type 6 Deletion Decreases Left Ventricular Function via Impaired Calcium Handling by TONG TANG, MEI HUA GAO, CHIN LAI, N, FIRTH, Amy L, TAKAHASHI, Toshiyuki, GUO, Tracy, YUAN, Jason X.-J, ROTH, David M, KIRK HAMMOND, H

“…Adenylyl cyclases (ACs) are a family of effector molecules for G-protein-coupled receptors. The 2 ACs most abundantly expressed in cardiac myocytes are types 5…”
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Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits by Ichikawa, Yasuhiro, Zemljic-Harpf, Alice E, Zhang, Zheng, McKirnan, M Dan, Manso, Ana Maria, Ross, Robert S, Hammond, H Kirk, Patel, Hemal H, Roth, David M

“…Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an…”
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Prospects for gene transfer for clinical heart failure by Tang, T, Gao, M H, Hammond, H Kirk

“…Congestive heart failure is an inexorable disease associated with unacceptably high morbidity and mortality. Preclinical results indicate that gene transfer…”
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Activation of Cardiac Adenylyl Cyclase Expression Increases Function of the Failing Ischemic Heart in Mice by Lai, N. Chin, PhD, Tang, Tong, PhD, Gao, Mei Hua, PhD, Saito, Miho, MD, Takahashi, Toshiyuki, MD, PhD, Roth, David M., MD, PhD, Hammond, H. Kirk, MD

“…Activation of Cardiac Adenylyl Cyclase Expression Increases Function of the Failing Ischemic Heart in Mice N. Chin Lai, Tong Tang, Mei Hua Gao, Miho Saito,…”
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Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer by Fang, Hongfei, Lai, Ngai Chin, Gao, Mei Hua, Miyanohara, Atsushi, Roth, David M, Tang, Tong, Hammond, H Kirk

“…Cardiac gene transfer is a potentially useful strategy for cardiovascular diseases. The adeno-associated virus (AAV) is a common vector to obtain transgene…”
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Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency by Gao, Mei Hua, Giamouridis, Dimosthenis, Lai, N. Chin, Guo, Tracy, Xia, Bing, Kim, Young Chul, Huu, Viet Anh Nguyen, Skowronska-Krawczyk, Dorota, Lantier, Louise, Bhargava, Raag, Hammond, H. Kirk

“…Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of…”
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Stimulation of Renin Secretion by Catecholamines Is Dependent on Adenylyl Cyclases 5 and 6 by Aldehni, Fadi, Tang, Tong, Madsen, Kirsten, Plattner, Michael, Schreiber, Andrea, Friis, Ulla G, Hammond, H. Kirk, Han, Pyung Lim, Schweda, Frank

“…The sympathetic nervous system stimulates renin release from juxtaglomerular cells via the β-adrenoreceptor-cAMP pathway. Recent in vitro studies have…”
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Clinical Evaluation of Heart Failure: Agreement among Tests by Pandey, Amit K, Penny, William F, Bhargava, Valmik, Lai, N Chin, Xu, Ronghui, Hammond, H Kirk

“…Methods commonly used clinically to assess cardiac function in patients with heart failure include ejection fraction (EF), exercise treadmill testing (ETT),…”
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