Search Results - "Hammond, Donna L"

Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats by Hamity, Marta V., White, Stephanie R., Walder, Roxanne Y., Schmidt, Mark S., Brenner, Charles, Hammond, Donna L.

“…Injury to sensory afferents may contribute to the peripheral neuropathies that develop after administration of chemotherapeutic agents. Manipulations that…”
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Nicotinamide riboside relieves paclitaxel-induced peripheral neuropathy and enhances suppression of tumor growth in tumor-bearing rats by Hamity, Marta V., White, Stephanie R., Blum, Christopher, Gibson-Corley, Katherine N., Hammond, Donna L.

“…Nicotinamide riboside (NR) is a vitamin B3 precursor of NAD that blunts diabetic and chemotherapy-induced peripheral neuropathy in preclinical models. This…”
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Heat hyperalgesia and mechanical hypersensitivity induced by calcitonin gene-related peptide in a mouse model of neurofibromatosis by White, Stephanie, Marquez de Prado, Blanca, Russo, Andrew F, Hammond, Donna L

“…This study examined whether mice with a deficiency of neurofibromin, a Ras GTPase activating protein, exhibit a nociceptive phenotype and probed a possible…”
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Substance P Enhances Excitatory Synaptic Transmission on Spinally Projecting Neurons in the Rostral Ventromedial Medulla After Inflammatory Injury by Zhang, Liang, Hammond, Donna L

“…1 Departments of Anesthesia and 2 Pharmacology, The University of Iowa, Iowa City, Iowa Submitted 18 December 2008; accepted in final form 31 May 2009 It has…”
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Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice by Marquez de Prado, Blanca, Hammond, Donna L, Russo, Andrew F

“…Calcitonin gene-related peptide (CGRP) is a key player in migraine. To address the role of CGRP in mechanical allodynia, which is a common feature of migraine,…”
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Effects of spinal nerve ligation on immunohistochemically identified neurons in the L4 and L5 dorsal root ganglia of the rat by Hammond, Donna L., Ackerman, Laurie, Holdsworth, Ryan, Elzey, Brian

“…This study examined the effect of spinal nerve ligation on different populations of immunohistochemically identified neurons in the dorsal root ganglia (DRG)…”
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Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia by HURLEY, Robert W, CHATTERJEA, Debika, FENG, Meihua Rose, TAYLOR, Charles P, HAMMOND, Donna L

“…Gabapentin and pregabalin are anticonvulsants with antihyperalgesic effects in animal models of neuropathic and inflammatory nociception. This study…”
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Nicotinamide Riboside Alleviates Corneal and Somatic Hypersensitivity Induced by Paclitaxel in Male Rats by Hamity, Marta V, Kolker, Sandra J, Hegarty, Deborah M, Blum, Christopher, Langmack, Lucy, Aicher, Sue A, Hammond, Donna L

“…Patients receiving chemotherapy may experience ocular discomfort and dry eye-like symptoms; the latter may be neuropathic in nature. This study assessed…”
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Electrophysiological Heterogeneity of Spinally Projecting Serotonergic and Nonserotonergic Neurons in the Rostral Ventromedial Medulla by Zhang, Liang, Sykes, Kenneth T, Buhler, Amber V, Hammond, Donna L

“…1 Departments of Anesthesia and 2 Pharmacology, The University of Iowa, Iowa City, Iowa Submitted 22 August 2005; accepted in final form 1 December 2005 This…”
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CaMKII binding to GluN2B at S1303 has no role in acute or inflammatory pain by Maduka, Uche P., White, Stephanie R., Joiner, Mei-Ling A., Hell, Johannes W., Hammond, Donna L.

“…[Display omitted] •Acute and inflammatory pain were tested in GluN2BKI mice impaired in CaMKII binding.•Loss of activity-driven CaMKII binding to GluN2B did…”
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A cellular mechanism for the antinociceptive effect of a kappa opioid receptor agonist by Ackley, Michael A, Hurley, Robert W, Virnich, Daniel E, Hammond, Donna L

“…This study used concordant behavioral and electrophysiological approaches to examine the actions of the prototypic kappa opioid receptor agonist U69593 in the…”
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Cellular basis for opioid potentiation in the rostral ventromedial medulla of rats with persistent inflammatory nociception by Zhang, Liang, Hammond, Donna L.

“…Direct inhibition of pain facilitatory neurons in the rostral ventromedial medulla (RVM) is one mechanism by which mu opioid receptor (MOPr) agonists are…”
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Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury by Hamity, Marta V., Walder, Roxanne Y., Hammond, Donna L.

“…ABSTRACT This study examined possible mechanisms by which Substance P (Sub P) assumes a pronociceptive role in the rostral ventromedial medulla (RVM) under…”
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Chloride regulation in the pain pathway by Price, Theodore J, Cervero, Fernando, Gold, Michael S, Hammond, Donna L, Prescott, Steven A

“…Abstract Melzack and Wall's Gate Control Theory of Pain laid the theoretical groundwork for a role of spinal inhibition in endogenous pain control. While the…”
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Plasticity in Brainstem Mechanisms of Pain Modulation by Nicotinic Acetylcholine Receptors in the Rat by Jareczek, Francis J, White, Stephanie R, Hammond, Donna L

“…Individuals with chronic pain may be driven to smoke more because the analgesic efficacy of nicotine diminishes. To determine whether persistent pain…”
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Peripheral inflammatory injury alters the relative abundance of Gα subunits in the dorsal horn of the spinal cord and in the rostral ventromedial medulla of male rats by Wattiez, Anne-Sophie, Walder, Roxanne Y, Sande, Christopher M, White, Stephanie R, Hammond, Donna L

“…A diverse array of G protein-coupled receptors (GPCRs) is implicated in the modulation of nociception. The efficacy and potency of several GPCR agonists change…”
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Validation of Four Reference Genes for Quantitative mRNA Expression Studies in a Rat Model of Inflammatory Injury by Walder, Roxanne Y, Wattiez, Anne-Sophie, White, Stephanie R, de Prado, Blanca Marquez, Hamity, Marta V, Hammond, Donna L

“…Background: Real-time quantitative PCR (qPCR) is a technique frequently used to measure changes in mRNA expression. To ensure validity of experimental…”
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Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons by Hahm, Eu-teum, Hammond, Donna L, Proudfit, Herbert K

“…Abstract This study investigated the ability of substance P (Sub P) to induce dendritic varicosities (DVs) or beads in neurons of the rostral ventromedial…”
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Spinal nerve ligation decreases γ-aminobutyric acidB receptors on specific populations of immunohistochemically identified neurons in L5 dorsal root ganglion of the rat by Engle, Mitchell P., Merrill, Michelle A., Marquez De Prado, Blanca, Hammond, Donna L.

“…This study examined the distribution of γ‐aminobutyric acid (GABA)B receptors on immunohistochemically identified neurons, and levels of GABAB(1) and GABAB(2)…”
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Persistent inflammatory pain decreases the antinociceptive effects of the mu opioid receptor agonist DAMGO in the locus coeruleus of male rats by Jongeling, Amy C., Johns, Malcolm E., Murphy, Anne Z., Hammond, Donna L.

“…Persistent inflammatory nociception increases levels of endogenous opioids with affinity for delta opioid receptors in the ventromedial medulla and enhances…”
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