Search Results - "Hammett, Maree"

Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult Thymus by Wong, Kahlia, Lister, Natalie L., Barsanti, Marco, Lim, Joanna M.C., Hammett, Maree V., Khong, Danika M., Siatskas, Christopher, Gray, Daniel H.D., Boyd, Richard L., Chidgey, Ann P.

“…Thymic epithelial cells (TECs) are critical for T cell development and self-tolerance but are gradually lost with age. The existence of thymic epithelial…”
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Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging by Lepletier, Ailin, Hun, Michael L., Hammett, Maree V., Wong, Kahlia, Naeem, Haroon, Hedger, Mark, Loveland, Kate, Chidgey, Ann P.

“…A key feature of immune functional impairment with age is the progressive involution of thymic tissue responsible for naive T cell production. In this study,…”
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Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer by Shu, Runzhe, Evtimov, Vera J., Hammett, Maree V., Nguyen, Nhu-Y N., Zhuang, Junli, Hudson, Peter J., Howard, Maureen C., Pupovac, Aleta, Trounson, Alan O., Boyd, Richard L.

“…Chimeric antigen receptor (CAR) T cells have revolutionized blood cancer immunotherapy; however, their efficacy against solid tumors has been limited. A common…”
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Targeting TAG-72 in cutaneous T cell lymphoma by Evtimov, Vera J., Hammett, Maree V., Pupovac, Aleta, Nguyen, Nhu-Y N., Shu, Runzhe, Van Der Weyden, Carrie, Twigger, Robert, Nisbet, Ian T., Trounson, Alan O., Boyd, Richard L., Prince, H. Miles

“…Current monoclonal antibody-based treatment approaches for cutaneous T cell lymphoma (CTCL) rely heavily on the ability to identify a tumor specific target…”
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Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade by Sutherland, Jayne S, Goldberg, Gabrielle L, Hammett, Maree V, Uldrich, Adam P, Berzins, Stuart P, Heng, Tracy S, Blazar, Bruce R, Millar, Jeremy L, Malin, Mark A, Chidgey, Ann P, Boyd, Richard L

“…The thymus undergoes age-related atrophy, coincident with increased circulating sex steroids from puberty. The impact of thymic atrophy is most profound in…”
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A novel Foxn1eGFP/+ mouse model identifies Bmp4‐induced maintenance of Foxn1 expression and thymic epithelial progenitor populations by Barsanti, Marco, Lim, Joanna M. C., Hun, Michael L., Lister, Natalie, Wong, Kahlia, Hammett, Maree V., Lepletier, Ailin, Boyd, Richard L., Giudice, Antonietta, Chidgey, Ann P.

“…Although forkhead‐box n1 (Foxn1) is a critical thymic epithelial cell regulator in thymus organogenesis, its association with epithelial differentiation and…”
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Ablation and Regeneration of Tolerance-Inducing Medullary Thymic Epithelial Cells after Cyclosporine, Cyclophosphamide, and Dexamethasone Treatment by Fletcher, Anne L, Lowen, Tamara E, Sakkal, Samy, Reiseger, Jessica J, Hammett, Maree V, Seach, Natalie, Scott, Hamish S, Boyd, Richard L, Chidgey, Ann P

“…Immunosuppressive drugs and cytotoxic chemotherapy agents are designed to kill or suppress autoreactive, alloaggressive, or hyperinflammatory T cells, or…”
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CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity by Bunting, Mark D., Comerford, Iain, Seach, Natalie, Hammett, Maree V., Asquith, Darren L., Körner, Heinrich, Boyd, Richard L., Nibbs, Robert J.B., McColl, Shaun R.

“…The atypical chemokine receptor CCX-CKR regulates bioavailability of CCL19, CCL21, and CCL25, homeostatic chemokines that play crucial roles in thymic…”
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Enhanced Hematopoietic Stem Cell Function Mediates Immune Regeneration following Sex Steroid Blockade by Khong, Danika M., Dudakov, Jarrod A., Hammett, Maree V., Jurblum, Marc I., Khong, Sacha M.L., Goldberg, Gabrielle L., Ueno, Tomoo, Spyroglou, Lisa, Young, Lauren F., van den Brink, Marcel R.M., Boyd, Richard L., Chidgey, Ann P.

“…Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced…”
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Thymic Deletion and Regulatory T Cells Prevent Antimyeloperoxidase GN by TAN, Diana S. Y, GAN, Poh Y, CHIDGEY, Ann P, HOLDSWORTH, Stephen R, O'SULLIVAN, Kim M, HAMMETT, Maree V, SUMMERS, Shaun A, OOI, Joshua D, LUNDGREN, Brita A, BOYD, Richard L, SCOTT, Hamish S, KITCHING, A. Richard

“…Loss of tolerance to neutrophil myeloperoxidase (MPO) underlies the development of ANCA-associated vasculitis and GN, but the mechanisms underlying this loss…”
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Engineering T cell receptor fusion proteins using nonviral CRISPR/Cas9 genome editing for cancer immunotherapy by Shu, Runzhe, Hammett, Maree, Evtimov, Vera, Pupovac, Aleta, Nguyen, Nhu-Y, Islam, Rasa, Zhuang, Junli, Lee, Seyeong, Kang, Tae-Hun, Lee, Kyujun, Nisbet, Ian, Hudson, Peter, Lee, Jae Young, Boyd, Richard, Trounson, Alan

“…Manufacture of chimeric antigen receptor (CAR)-T cells usually involves the use of viral delivery systems to achieve high transgene expression. However, it can…”
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A novel Foxn1 eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations by Barsanti, Marco, Lim, Joanna M C, Hun, Michael L, Lister, Natalie, Wong, Kahlia, Hammett, Maree V, Lepletier, Ailin, Boyd, Richard L, Giudice, Antonietta, Chidgey, Ann P

“…Although forkhead-box n1 (Foxn1) is a critical thymic epithelial cell regulator in thymus organogenesis, its association with epithelial differentiation and…”
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Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice by Goldberg, Gabrielle L, Dudakov, Jarrod A, Reiseger, Jessica J, Seach, Natalie, Ueno, Tomoo, Vlahos, Katerina, Hammett, Maree V, Young, Lauren F, Heng, Tracy S P, Boyd, Richard L, Chidgey, Ann P

“…Cytotoxic antineoplastic therapy is used to treat malignant disease but results in long-term immunosuppression in postpubertal and adult individuals, leading…”
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Enhanced Immune Reconstitution by Sex Steroid Ablation following Allogeneic Hemopoietic Stem Cell Transplantation by Goldberg, Gabrielle L, Alpdogan, Onder, Muriglan, Stephanie J, Hammett, Maree V, Milton, Morag K, Eng, Jeffrey M, Hubbard, Vanessa M, Kochman, Adam, Willis, Lucy M, Greenberg, Andrew S, Tjoe, Kartono H, Sutherland, Jayne S, Chidgey, Ann, van den Brink, Marcel R. M, Boyd, Richard L

“…Delayed immune reconstitution in adult recipients of allogeneic hemopoietic stem cell transplantations (HSCT) is related to age-induced thymic atrophy…”
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Unbiased analysis, enrichment and purification of thymic stromal cells by Gray, Daniel H.D., Fletcher, Anne L., Hammett, Maree, Seach, Natalie, Ueno, Tomoo, Young, Lauren F., Barbuto, Jade, Boyd, Richard L., Chidgey, Ann P.

“…The microenvironment of the thymus consists of functionally discrete niches composed of distinct stromal cell subsets. Clinically relevant changes affecting…”
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Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunity by Fletcher, Anne L, Seach, Natalie, Reiseger, Jessica J, Lowen, Tamara E, Hammett, Maree V, Scott, Hamish S, Boyd, Richard L

“…The thymic stromal niche normally directs the production and export of a self-tolerant T cell repertoire. Many models of spontaneous autoimmunity, however,…”
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Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches by Chidgey, Ann P., Seach, Natalie, Dudakov, Jarrod, Hammett, Maree V., Boyd, Richard L.

“…Poor immune recovery is characteristic of bone marrow transplantation and leads to high levels of morbidity and mortality. The primary underlying cause is a…”
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Purified enzymes improve isolation and characterization of the adult thymic epithelium by Seach, Natalie, Wong, Kahlia, Hammett, Maree, Boyd, Richard L., Chidgey, Ann P.

“…The reproducible isolation and accurate characterization of thymic epithelial cell (TEC) subsets is of critical importance to the ongoing study of thymopoiesis…”
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A novel Foxn1 super(eGFP/+) mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations by Barsanti, Marco, Lim, Joanna MC, Hun, Michael L, Lister, Natalie, Wong, Kahlia, Hammett, Maree V, Lepletier, Ailin, Boyd, Richard L, Giudice, Antonietta, Chidgey, Ann P

“…Although forkhead-box n1 (Foxn1) is a critical thymic epithelial cell regulator in thymus organogenesis, its association with epithelial differentiation and…”
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Isolation, characterization, and reaggregate culture of thymic epithelial cells by Seach, Natalie, Hammett, Maree, Chidgey, Ann

“…The thymus organ is composed of a three-dimensional (3D) network of adjoining epithelium and stromal cells. Bone marrow-derived T cell precursors, upon…”
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