Search Results - "Hammes, Stephen R."

Impact of estrogens in males and androgens in females by Hammes, Stephen R, Levin, Ellis R

“…Androgens and estrogens are known to be critical regulators of mammalian physiology and development. While these two classes of steroids share similar…”
Get full text

Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) and Cancer: A Novel Potential Therapeutic Target by Taya, Manisha, Hammes, Stephen R.

“…•GPNMB facilitates tumor growth, cancer cell migration, invasion, and metastasis.•Full length GPNMB mediates the tumor microenvironment in a cell autonomous…”
Get full text

Extranuclear Steroid Receptors: Nature and Actions by Hammes, Stephen R, Levin, Ellis R

“…Rapid effects of steroid hormones result from the actions of specific receptors localized most often to the plasma membrane. Fast-acting membrane-initiated…”
Get full text

Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression by Sen, Aritro, Prizant, Hen, Light, Allison, Biswas, Anindita, Hayes, Emily, Lee, Ho-Joon, Barad, David, Gleicher, Norbert, Hammes, Stephen R.

“…Although androgen excess is considered detrimental to women’s health and fertility, global and ovarian granulosa cell-specific androgen-receptor (AR) knockout…”
Get full text

Minireview: Lymphangioleiomyomatosis (LAM): The “Other” Steroid-Sensitive Cancer by Prizant, Hen, Hammes, Stephen R

“…Lymphangioleiomyomatosis (LAM) is a devastating rare lung disease affecting primarily childbearing age women in which tumors consisting of abnormal…”
Get full text

Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase by Lerman, Irina, Garcia-Hernandez, Maria de la Luz, Rangel-Moreno, Javier, Chiriboga, Luis, Pan, Chunliu, Nastiuk, Kent L, Krolewski, John J, Sen, Aritro, Hammes, Stephen R

“…Tissue infiltration and elevated peripheral circulation of granulocytic myeloid-derived cells is associated with poor outcomes in prostate cancer and other…”
Get full text

Aromatase deficiency in a male patient - case report and review of the literature by Miedlich, Susanne U, Karamooz, Nima, Hammes, Stephen R

“…Abstract Objective Aromatase, or CYP19A1, is a type II cytochrome CYP450 enzyme that catalyzes the conversion of C19 androgens to C18 estrogens. Its crucial…”
Get full text

Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females by Ma, Xiaoting, Hayes, Emily, Prizant, Hen, Srivastava, Rajesh K, Hammes, Stephen R, Sen, Aritro

“…Obesity is considered detrimental to women's reproductive health. Although most of the attention has been focused on the effects of obesity on hypothalamic…”
Get full text

Cross-talk between G Protein-coupled and Epidermal Growth Factor Receptors Regulates Gonadotropin-mediated Steroidogenesis in Leydig Cells by Evaul, Kristen, Hammes, Stephen R.

“…Gonadal steroid production is stimulated by gonadotropin binding to G protein-coupled receptors (GPCRs). Although GPCR-mediated increases in intracellular cAMP…”
Get full text

Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation by Sen, Aritro, De Castro, Ismary, Defranco, Donald B, Deng, Fang-Ming, Melamed, Jonathan, Kapur, Payel, Raj, Ganesh V, Rossi, Randall, Hammes, Stephen R

“…In prostate cancer, the signals that drive cell proliferation change as tumors progress from castration-sensitive (androgen-dominant) to castration-resistant…”
Get full text

Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth by Taya, Manisha, Garcia-Hernandez, Maria de la Luz, Rangel-Moreno, Javier, Minor, Briaunna, Gibbons, Erin, Hammes, Stephen R

“…Chronic inflammation promotes progression of many cancers, with circulating myeloid-derived suppressor cell (MDSC) levels correlating with poor prognosis. Here…”
Get full text

Ovarian Steroids: The Good, the Bad, and the Signals that Raise Them by Jamnongjit, Michelle, Hammes, Stephen R.

“…Ovarian steroid production and subsequent local steroid-mediated signaling are critical for normal ovarian processes, including follicle growth, oocyte…”
Get full text

AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells by Xiao, Zhiguang, Hammes, Stephen R.

“…Neutrophil elastase (NE) promotes multiple stages of tumorigenesis. However, little is known regarding the molecular mechanisms underlying its stimulatory…”
Get full text

Epidermal Growth Factor Receptor Signaling Is Required for Normal Ovarian Steroidogenesis and Oocyte Maturation by Michelle Jamnongjit, Arvind Gill, Hammes, Stephen R.

“…The midcycle luteinizing hormone (LH) surge triggers several tightly linked ovarian processes, including steroidogenesis, oocyte maturation, and ovulation. We…”
Get full text

Paxillin Regulates Androgen- and Epidermal Growth Factor-induced MAPK Signaling and Cell Proliferation in Prostate Cancer Cells by Sen, Aritro, O'Malley, Katherine, Wang, Zhou, Raj, Ganesh V., DeFranco, Donald B., Hammes, Stephen R.

“…Although transcriptional effects of androgens have been extensively studied, mechanisms regulating transcription-independent (nongenomic) androgen actions are…”
Get full text

Steroids and Oocyte Maturation—A New Look at an Old Story by Hammes, Stephen R

“…Female fertility requires precise regulation of oocyte meiosis. Oocytes are arrested early in the meiotic cycle until just before ovulation, when ovarian…”
Get full text

Spatially Defined EGF Receptor Activation Reveals an F-Actin-Dependent Phospho-Erk Signaling Complex by Singhai, Amit, Wakefield, Devin L., Bryant, Kirsten L., Hammes, Stephen R., Holowka, David, Baird, Barbara

“…We investigated the association of signaling proteins with epidermal growth factor (EGF) receptors (EGFR) using biotinylated EGF bound to streptavidin that is…”
Get full text

Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-G βγ Inhibition Halts Heart Failure Progression by Kamal, Fadia A., PharmD, PhD, Mickelsen, Deanne M., BS, Wegman, Katherine M, Travers, Joshua G., BS, Moalem, Jacob, MD, Hammes, Stephen R., MD, PhD, Smrcka, Alan V., PhD, Blaxall, Burns C., PhD

“…Objectives The authors propose simultaneous inhibition of Gβγ signaling in the heart and the adrenal gland as a novel therapeutic approach for heart failure…”
Get full text

Membrane receptor cross talk in steroidogenesis: Recent insights and clinical implications by Light, Allison, Hammes, Stephen R.

“…► Steroidogenesis in the gonads and adrenal gland require LH/EGFR cross talk. ► Steroidogenesis in the ovary uniquely requires matrix metalloproteinases. ►…”
Get full text

Neutrophil elastase in the tumor microenvironment by Lerman, Irina, Hammes, Stephen R.

“…Myeloid cell production within the bone marrow is accelerated in the setting of cancer, and the numbers of circulating and infiltrating neutrophils and…”
Get full text