Search Results - "Hammes, Stephen"

Impact of estrogens in males and androgens in females by Hammes, Stephen R, Levin, Ellis R

“…Androgens and estrogens are known to be critical regulators of mammalian physiology and development. While these two classes of steroids share similar…”
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Neutrophil elastase in the tumor microenvironment by Lerman, Irina, Hammes, Stephen R.

“…Myeloid cell production within the bone marrow is accelerated in the setting of cancer, and the numbers of circulating and infiltrating neutrophils and…”
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Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors by Levin, Ellis R., Hammes, Stephen R.

“…Key Points Steroid receptors classically function in the nucleus, regulating the expression of genes that are important for a wide range of cellular functions…”
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Granulosa Cell-Specific Androgen Receptors Are Critical Regulators of Ovarian Development and Function by Sen, Aritro, Hammes, Stephen R

“…The physiological significance of androgens in female reproduction was unclear until female mice with global knockout of androgen receptor (AR) expression were…”
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Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) and Cancer: A Novel Potential Therapeutic Target by Taya, Manisha, Hammes, Stephen R.

“…•GPNMB facilitates tumor growth, cancer cell migration, invasion, and metastasis.•Full length GPNMB mediates the tumor microenvironment in a cell autonomous…”
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Extranuclear Steroid Receptors: Nature and Actions by Hammes, Stephen R, Levin, Ellis R

“…Rapid effects of steroid hormones result from the actions of specific receptors localized most often to the plasma membrane. Fast-acting membrane-initiated…”
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Physiological and Pathological Androgen Actions in the Ovary by Astapova, Olga, Minor, Briaunna M N, Hammes, Stephen R

“…Androgens, although traditionally thought to be male sex steroids, play important roles in female reproduction, both in healthy and pathological states. This…”
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Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression by Sen, Aritro, Prizant, Hen, Light, Allison, Biswas, Anindita, Hayes, Emily, Lee, Ho-Joon, Barad, David, Gleicher, Norbert, Hammes, Stephen R.

“…Although androgen excess is considered detrimental to women’s health and fertility, global and ovarian granulosa cell-specific androgen-receptor (AR) knockout…”
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Minireview: Lymphangioleiomyomatosis (LAM): The “Other” Steroid-Sensitive Cancer by Prizant, Hen, Hammes, Stephen R

“…Lymphangioleiomyomatosis (LAM) is a devastating rare lung disease affecting primarily childbearing age women in which tumors consisting of abnormal…”
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Paxillin actions in the nucleus by Ma, Xiaoting, Hammes, Stephen R.

“…Paxillin is a group III LIM domain protein that is best characterized as a cytoplasmic scaffold/adaptor protein that functions primarily as a mediator of focal…”
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Minireview: Recent Advances in Extranuclear Steroid Receptor Actions by Hammes, Stephen R, Levin, Ellis R

“…The participation of extranuclear steroid receptor signaling in organ physiology and the impact for pathobiology has increasingly been demonstrated. Important…”
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Paxillin regulated genomic networks in prostate cancer by Ma, Xiaoting, Biswas, Anindita, Hammes, Stephen R.

“…Paxillin is extensively involved in focal adhesion signaling and kinase signaling throughout the plasma membrane and cytoplasm. However, recent studies in…”
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LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands by Light, Allison, Hammes, Stephen R

“…Oocyte maturation and cumulus cell expansion depend on luteinizing hormone (LH)-mediated upregulation of membrane-bound epidermal growth factor (EGF)-like…”
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Rapid Signaling and Genomic Steroid Hormone Actions in Health and Disease by Hammes, Stephen R

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Publish or Perish: Five Steps to Navigating a Less Painful Peer Review by Lange, Carol A, Hammes, Stephen R

“…This Perspective presents comments intended for junior researchers by Carol A. Lange, Editor-in-Chief, Endocrinology, and Stephen R. Hammes, former…”
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Lymphangioleiomyomatosis: where endocrinology, immunology and tumor biology meet by Gibbons, Erin, Minor, Briaunna M N, Hammes, Stephen R

“…Graphical abstract Abstract Lymphangioleiomyomatosis (LAM) is a cystic lung disease found almost exclusively in genetic females and caused by small clusters of…”
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Editorial: Final Musings on the Impact of Molecular Endocrinology by Hammes, Stephen R

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Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase by Lerman, Irina, Garcia-Hernandez, Maria de la Luz, Rangel-Moreno, Javier, Chiriboga, Luis, Pan, Chunliu, Nastiuk, Kent L, Krolewski, John J, Sen, Aritro, Hammes, Stephen R

“…Tissue infiltration and elevated peripheral circulation of granulocytic myeloid-derived cells is associated with poor outcomes in prostate cancer and other…”
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Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell by Guo, Minzhe, Yu, Jane J, Perl, Anne Karina, Wikenheiser-Brokamp, Kathryn A, Riccetti, Matt, Zhang, Erik Y, Sudha, Parvathi, Adam, Mike, Potter, Andrew, Kopras, Elizabeth J, Giannikou, Krinio, Potter, S Steven, Sherman, Sue, Hammes, Stephen R, Kwiatkowski, David J, Whitsett, Jeffrey A, McCormack, Francis X, Xu, Yan

“…Lymphangioleiomyomatosis (LAM) is a metastatic neoplasm of reproductive-age women associated with mutations in tuberous sclerosis complex genes. LAM causes…”
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Aromatase deficiency in a male patient - case report and review of the literature by Miedlich, Susanne U, Karamooz, Nima, Hammes, Stephen R

“…Abstract Objective Aromatase, or CYP19A1, is a type II cytochrome CYP450 enzyme that catalyzes the conversion of C19 androgens to C18 estrogens. Its crucial…”
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