Search Results - "Hammer, Stephan C."

Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis by Hammer, Stephan C., Kubik, Grzegorz, Watkins, Ella, Huang, Shan, Minges, Hannah, Arnold, Frances H.

“…Catalytic anti-Markovnikov oxidation of alkene feedstocks could simplify synthetic routes to many important molecules and solve a long-standing challenge in…”
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New Generation of Biocatalysts for Organic Synthesis by Nestl, Bettina M., Hammer, Stephan C., Nebel, Bernd A., Hauer, Bernhard

“…The use of enzymes as catalysts for the preparation of novel compounds has received steadily increasing attention over the past few years. High demands are…”
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Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non‐natural Terpenoids by Aberle, Benjamin, Kowalczyk, Daniel, Massini, Simon, Egler‐Kemmerer, Alexander‐N., Gergel, Sebastian, Hammer, Stephan C., Hauer, Bernhard

“…Terpenoids are built from isoprene building blocks and have numerous biological functions. Selective late‐stage modification of their carbon scaffold has the…”
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Asymmetric Enzymatic Hydration of Unactivated, Aliphatic Alkenes by Demming, Rebecca M., Hammer, Stephan C., Nestl, Bettina M., Gergel, Sebastian, Fademrecht, Silvia, Pleiss, Jürgen, Hauer, Bernhard

“…The direct enantioselective addition of water to unactivated alkenes could simplify the synthesis of chiral alcohols and solve a long‐standing challenge in…”
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A New Age of Biocatalysis Enabled by Generic Activation Modes by Jain, Shubhanshu, Ospina, Felipe, Hammer, Stephan C.

“…Biocatalysis is currently undergoing a profound transformation. The field moves from relying on nature’s chemical logic to a discipline that exploits generic…”
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Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective C C and C X bond formation by Hammer, Stephan C, Syrén, Per-Olof, Seitz, Miriam, Nestl, Bettina M, Hauer, Bernhard

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Fast and easy synthesis of the non-commercially available standard isobutyl monophosphate (ammonium salt) by Escobedo-Hinojosa, Wendy, Hammer, Stephan C., Wissner, Julian L., Hauer, Bernhard

“…In an attempt to establish a biosynthetic route towards isobutene, we faced the problem that the first intermediate isobutyl-monophosphate was not commercially…”
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Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis by Hammer, Stephan C, Marjanovic, Antonija, Dominicus, Jörg M, Nestl, Bettina M, Hauer, Bernhard

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Enzymatic Control over Reactive Intermediates Enables Direct Oxidation of Alkenes to Carbonyls by a P450 Iron-Oxo Species by Soler, Jordi, Gergel, Sebastian, Klaus, Cindy, Hammer, Stephan C., Garcia-Borràs, Marc

“…The aerobic oxidation of alkenes to carbonyls is an important and challenging transformation in synthesis. Recently, a new P450-based enzyme (aMOx) has been…”
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Engineered Enzymes Enable Selective N‐Alkylation of Pyrazoles With Simple Haloalkanes by Bengel, Ludwig L., Aberle, Benjamin, Egler‐Kemmerer, Alexander‐N., Kienzle, Samuel, Hauer, Bernhard, Hammer, Stephan C.

“…Selective alkylation of pyrazoles could solve a challenge in chemistry and streamline synthesis of important molecules. Here we report catalyst‐controlled…”
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Comparative S -adenosyl-L-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation by Hoffmann, Arne, Schülke, Kai H, Hammer, Stephan C, Rentmeister, Andrea, Cornelissen, Nicolas V

“…Methyltransferases provide excellent specificity in late-stage alkylation of biomolecules. Their dependence on -adenosyl-L-methionine (SAM) mandates efficient…”
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Substrate Profiling of Anion Methyltransferases for Promiscuous Synthesis of S‐Adenosylmethionine Analogs from Haloalkanes by Schülke, Kai H., Ospina, Felipe, Hörnschemeyer, Kathrin, Gergel, Sebastian, Hammer, Stephan C.

“…Biocatalytic alkylation reactions can be performed with high chemo‐, regio‐ and stereoselectivity using S‐adenosyl‐l‐methionine (SAM)‐dependent…”
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Chiral Alcohols from Alkenes and Water: Directed Evolution of a Styrene Hydratase by Gajdoš, Matúš, Wagner, Jendrik, Ospina, Felipe, Köhler, Antonia, Engqvist, Martin K. M., Hammer, Stephan C.

“…Enantioselective synthesis of chiral alcohols through asymmetric addition of water across an unactivated alkene is a highly sought‐after transformation and a…”
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Selective Biocatalytic N‐Methylation of Unsaturated Heterocycles by Ospina, Felipe, Schülke, Kai H., Soler, Jordi, Klein, Alina, Prosenc, Benjamin, Garcia‐Borràs, Marc, Hammer, Stephan C.

“…Methods for regioselective N‐methylation and ‐alkylation of unsaturated heterocycles with “off the shelf” reagents are highly sought‐after. This reaction could…”
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Asymmetric Enzymatic Hydration of Unactivated, Aliphatic Alkenes by Demming, Rebecca M., Hammer, Stephan C., Nestl, Bettina M., Gergel, Sebastian, Fademrecht, Silvia, Pleiss, Jürgen, Hauer, Bernhard

“…The direct enantioselective addition of water to unactivated alkenes could simplify the synthesis of chiral alcohols and solve a long‐standing challenge in…”
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Front Cover: Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes (ChemBioChem 10/2024) by Schülke, Kai H., Fröse, Jana S., Klein, Alina, Garcia‐Borràs, Marc, Hammer, Stephan C.

“…The cover image depicts snapshots of an enzyme′s dynamic behavior derived from molecular dynamics simulations. Protein movements can provide valuable insights…”
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Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl‐Alkenes Catalyzed by Laboratory Evolved P450s by Soler, Jordi, Gergel, Sebastian, Hammer, Stephan C., Garcia‐Borràs, Marc

“…P450 enzymes naturally perform selective hydroxylations and epoxidations of unfunctionalized hydrocarbon substrates, among other reactions. The adaptation of…”
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Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis by Hammer, Stephan C, Marjanovic, Antonija, Dominicus, Jörg M, Nestl, Bettina M, Hauer, Bernhard

“…Biocatalysis can take advantage of an enzyme's inherent reactivity regardless of its physiological role, as shown for a terpene cyclase turned Brønsted acid…”
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Controlling Monoterpene Isomerization by Guiding Challenging Carbocation Rearrangement Reactions in Engineered Squalene‐Hopene Cyclases by Ludwig, Julian, Curado‐Carballada, Christian, Hammer, Stephan C., Schneider, Andreas, Diether, Svenja, Kress, Nico, Ruiz‐Barragán, Sergi, Osuna, Sílvia, Hauer, Bernhard

“…The interconversion of monoterpenes is facilitated by a complex network of carbocation rearrangement pathways. Controlling these isomerization pathways is…”
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Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones by Scheller, Philipp N., Lenz, Maike, Hammer, Stephan C., Hauer, Bernhard, Nestl, Bettina M.

“…Imine reductases (IREDs) have emerged as promising biocatalysts for the synthesis of chiral amines. In this study, the asymmetric imine reductase‐catalyzed…”
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