Search Results - "Hammer, Sandra S"

Extracellular Vesicle-Induced Classical Complement Activation Leads to Retinal Endothelial Cell Damage via MAC Deposition by Huang, Chao, Fisher, Kiera P, Hammer, Sandra S, Busik, Julia V

“…Several studies have suggested that there is a link between membrane attack complex (MAC) deposition in the retina and the progression of diabetic retinopathy…”
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2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis by El-Darzi, Nicole, Mast, Natalia, Hammer, Sandra S., Dorweiler, Tim F., Busik, Julia V., Pikuleva, Irina A.

“…CYP46A1 is a CNS-specific enzyme, which eliminates cholesterol from the brain and retina by metabolism to 24-hydroxycholesterol, thus contributing to…”
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ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability by Kady, Nermin M, Liu, Xuwen, Lydic, Todd A, Syed, Meesum H, Navitskaya, Svetlana, Wang, Qi, Hammer, Sandra S, O'Reilly, Sandra, Huang, Chao, Seregin, Sergey S, Amalfitano, Andrea, Chiodo, Vince A, Boye, Sanford L, Hauswirth, William W, Antonetti, David A, Busik, Julia V

“…Tight junctions (TJs) involve close apposition of transmembrane proteins between cells. Although TJ proteins have been studied in detail, the role of lipids is…”
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Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes by Levitsky, Yan, Hammer, Sandra S, Fisher, Kiera P, Huang, Chao, Gentles, Travan L, Pegouske, David J, Xi, Caimin, Lydic, Todd A, Busik, Julia V, Proshlyakov, Denis A

“…Mitochondrial damage in the cells comprising inner (retinal endothelial cells) and outer (retinal pigment epithelium (RPE)) blood-retinal barriers (BRB) is…”
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The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor by Hammer, Sandra S., Beli, Eleni, Kady, Nermin, Wang, Qi, Wood, Kiana, Lydic, Todd A., Malek, Goldis, Saban, Daniel R., Wang, Xiaoxin X., Hazra, Sugata, Levi, Moshe, Busik, Julia V., Grant, Maria B.

“…Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite…”
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The role of dyslipidemia in diabetic retinopathy by Hammer, Sandra S., Busik, Julia V.

“…Diabetic retinopathy (DR) affects over 93million people worldwide and is the number one cause of blindness among working age adults. These indicators coupled…”
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Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway by Huang, Chao, Fisher, Kiera P, Hammer, Sandra S, Navitskaya, Svetlana, Blanchard, Gary J, Busik, Julia V

“…Diabetic retinopathy (DR) is a microvascular complication of diabetes and is the leading cause of vision loss in working-age adults. Recent studies have…”
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Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction by Hammer, Sandra S., Vieira, Cristiano P., McFarland, Delaney, Sandler, Maximilian, Levitsky, Yan, Dorweiler, Tim F., Lydic, Todd A., Asare-Bediako, Bright, Adu-Agyeiwaah, Yvonne, Sielski, Micheli S., Dupont, Mariana, Longhini, Ana Leda, Li Calzi, Sergio, Chakraborty, Dibyendu, Seigel, Gail M., Proshlyakov, Denis A., Grant, Maria B., Busik, Julia V.

“…Aims/hypothesis Homo sapiens evolved under conditions of intermittent food availability and prolonged fasting between meals. Periods of fasting are important…”
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Cholesterol crystal formation is a unifying pathogenic mechanism in the development of diabetic retinopathy by Hammer, Sandra S., Dorweiler, Tim F., McFarland, Delaney, Adu-Agyeiwaah, Yvonne, Mast, Natalia, El-Darzi, Nicole, Fortmann, Seth D., Nooti, Sunil, Agrawal, Devendra K., Pikuleva, Irina A., Abela, George S., Grant, Maria B., Busik, Julia V.

“…Aims/hypothesis Hyper-reflective crystalline deposits found in retinal lesions have been suggested to predict the progression of diabetic retinopathy, but the…”
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Epoxygenated Fatty Acids Inhibit Retinal Vascular Inflammation by Capozzi, Megan E., Hammer, Sandra S., McCollum, Gary W., Penn, John S.

“…The objective of the present study was to assess the effect of elevating epoxygenated fatty acids on retinal vascular inflammation. To stimulate inflammation…”
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The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis by Capozzi, Megan E., Savage, Sara R., McCollum, Gary W., Hammer, Sandra S., Ramos, Carla J., Yang, Rong, Bretz, Colin A., Penn, John S.

“…Diabetic retinopathy (DR) is triggered by retinal cell damage stimulated by the diabetic milieu, including increased levels of intraocular free fatty acids…”
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Micro-respirometry of whole cells and isolated mitochondria by Levitsky, Yan, Pegouske, David J, Hammer, Sandra S, Frantz, Nathan L, Fisher, Kiera P, Muchnik, Artem B, Saripalli, Anand R, Kirschner, Philip, Bazil, Jason N, Busik, Julia V, Proshlyakov, Denis A

“…Oxygen consumption is a key metric of metabolism in aerobic organisms. Current respirometric methods led to seminal discoveries despite limitations such as…”
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Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes by Vieira, Cristiano P, Fortmann, Seth D, Hossain, Masroor, Longhini, Ana Leda, Hammer, Sandra S, Asare-Bediako, Bright, Crossman, David K, Sielski, Micheli S, Adu-Agyeiwaah, Yvonne, Dupont, Mariana, Floyd, Jason L, Li Calzi, Sergio, Lydic, Todd, Welner, Robert S, Blanchard, Gary J, Busik, Julia V, Grant, Maria B

“…In diabetic dyslipidemia, cholesterol accumulates in the plasma membrane, decreasing fluidity and thereby suppressing the ability of cells to transduce…”
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