Search Results - "Hammer, Robert"

Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models by Nguyen, Liem H., Robinton, Daisy A., Seligson, Marc T., Wu, Linwei, Li, Lin, Rakheja, Dinesh, Comerford, Sarah A., Ramezani, Saleh, Sun, Xiankai, Parikh, Monisha S., Yang, Erin H., Powers, John T., Shinoda, Gen, Shah, Samar P., Hammer, Robert E., Daley, George Q., Zhu, Hao

“…Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often…”
Get full text

Acetate Dependence of Tumors by Comerford, Sarah A., Huang, Zhiguang, Du, Xinlin, Wang, Yun, Cai, Ling, Witkiewicz, Agnes K., Walters, Holly, Tantawy, Mohammed N., Fu, Allie, Manning, H. Charles, Horton, Jay D., Hammer, Robert E., McKnight, Steven L., Tu, Benjamin P.

“…Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation, and the regulation of gene expression…”
Get full text

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent by Comerford, Sarah A, Hinnant, Elizabeth A, Chen, Yidong, Hammer, Robert E

“…Defective ribosome biogenesis (RiBi) underlies a group of clinically diverse human diseases collectively known as the ribosomopathies, core manifestations of…”
Get full text

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice[S] by Linden, Albert G., Li, Shili, Choi, Hwa Y., Fang, Fei, Fukasawa, Masashi, Uyeda, Kosaku, Hammer, Robert E., Horton, Jay D., Engelking, Luke J., Liang, Guosheng

“…Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which transcriptionally activates genes involved in FA synthesis,…”
Get full text

Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis by Garcia, Joseph A, Chen, Rui, Xu, Min, Comerford, Sarah A, Hammer, Robert E, Melton, Shelby D, Feagins, Linda A

“…The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators…”
Get full text

White Fat Progenitor Cells Reside in the Adipose Vasculature by Tang, Wei, Zeve, Daniel, Suh, Jae Myoung, Bosnakovski, Darko, Kyba, Michael, Hammer, Robert E, Tallquist, Michelle D, Graff, Jonathan M

“…White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage…”
Get full text

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase by Owen, Joshua L, Zhang, Yuanyuan, Bae, Soo-Han, Farooqi, Midhat S, Liang, Guosheng, Hammer, Robert E, Goldstein, Joseph L, Brown, Michael S

“…Insulin activates sterol regulatory element-binding protein-1c (SREBP-1c) in liver, thereby increasing fatty acid and triglyceride synthesis. We created a line…”
Get full text

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 by Samuel, Buck S, Shaito, Abdullah, Motoike, Toshiyuki, Rey, Federico E, Backhed, Fredrik, Manchester, Jill K, Hammer, Robert E, Williams, S. Clay, Crowley, Jan, Yanagisawa, Masashi, Gordon, Jeffrey I

“…The distal human intestine harbors trillions of microbes that allow us to extract calories from otherwise indigestible dietary polysaccharides. The products of…”
Get full text

A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice by Tabuchi, Katsuhiko, Blundell, Jacqueline, Etherton, Mark R., Hammer, Robert E., Liu, Xinran, Powell, Craig M., Südhof, Thomas C.

“…Autism spectrum disorders (ASDs) are characterized by impairments in social behaviors that are sometimes coupled to specialized cognitive abilities. A small…”
Get full text

miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19 by Acharya, Asha, Berry, Daniel C, Zhang, He, Jiang, Yuwei, Jones, Benjamin T, Hammer, Robert E, Graff, Jonathan M, Mendell, Joshua T

“…Fat storage in adult mammals is a highly regulated process that involves the mobilization of adipocyte progenitor cells (APCs) that differentiate to produce…”
Get full text

p53 genes function to restrain mobile elements by Wylie, Annika, Jones, Amanda E, D'Brot, Alejandro, Lu, Wan-Jin, Kurtz, Paula, Moran, John V, Rakheja, Dinesh, Chen, Kenneth S, Hammer, Robert E, Comerford, Sarah A, Amatruda, James F, Abrams, John M

“…Throughout the animal kingdom, p53 genes govern stress response networks by specifying adaptive transcriptional responses. The human member of this gene family…”
Get full text

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade by Gu, Yi-Feng, Cohn, Shannon, Christie, Alana, McKenzie, Tiffani, Wolff, Nicholas, Do, Quyen N, Madhuranthakam, Ananth J, Pedrosa, Ivan, Wang, Tao, Dey, Anwesha, Busslinger, Meinrad, Xie, Xian-Jin, Hammer, Robert E, McKay, Renée M, Kapur, Payal, Brugarolas, James

“…Clear cell renal cell carcinoma (ccRCC) is characterized by and mutations, which are associated with tumors of different grade and prognosis. However, whether…”
Get more information

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice by Moon, Young-Ah, Hammer, Robert E., Horton, Jay D.

“…Elongation of very long chain fatty acids (ELOVL)5 is one of seven mammalian fatty acid condensing enzymes involved in microsomal fatty acid elongation. To…”
Get full text

FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system by Choi, Mihwa, Schneeberger, Marc, Fan, Wei, Bugde, Abhijit, Gautron, Laurent, Vale, Kevin, Hammer, Robert E., Zhang, Yuan, Friedman, Jeffrey M., Mangelsdorf, David J., Kliewer, Steven A.

“…Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the detrimental effects of inebriation. In this report, we show that…”
Get full text

A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling by Nagati, Jason S, Xu, Min, Garcia, Trent, Comerford, Sarah A, Hammer, Robert E, Garcia, Joseph A

“…The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional…”
Get full text

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis by Xian, Xunde, Ding, Yinyuan, Dieckmann, Marco, Zhou, Li, Plattner, Florian, Liu, Mingxia, Parks, John S, Hammer, Robert E, Boucher, Philippe, Tsai, Shirling, Herz, Joachim

“…Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor with diverse physiological roles, ranging from cellular…”
Get full text

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis by Wang, Shan-Shan, Gu, Yi-Feng, Wolff, Nicholas, Stefanius, Karoliina, Christie, Alana, Dey, Anwesha, Hammer, Robert E., Xie, Xian-Jin, Rakheja, Dinesh, Pedrosa, Ivan, Carroll, Thomas, McKay, Renée M., Kapur, Payal, Brugarolas, James

“…Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes…”
Get full text

Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals by Jones, Benjamin T, Han, Jaeil, Zhang, He, Hammer, Robert E, Evers, Bret M, Rakheja, Dinesh, Acharya, Asha, Mendell, Joshua T

“…MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target-directed miRNA…”
Get full text

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism by Wang, Jian, Alexander, Peter, Wu, Leeju, Hammer, Robert, Cleaver, Ondine, McKnight, Steven L

“…Measurements of the abundance of common metabolites in cultured embryonic stem (ES) cells revealed an unusual state with respect to one-carbon metabolism…”
Get full text

Unconventional mechanism of action and resistance to rapalogs in renal cancer by Yang, Juan, Butti, Ramesh, Cohn, Shannon, Toffessi-Tcheuyap, Vanina, Mal, Arijit, Nguyen, Mylinh, Stevens, Christina, Christie, Alana, Mishra, Akhilesh, Ma, Yuanqing, Kim, Jiwoong, Abraham, Robert, Kapur, Payal, Hammer, Robert E, Brugarolas, James

“…mTORC1 is aberrantly activated in renal cell carcinoma (RCC) and is targeted by rapalogs. As for other targeted therapies, rapalogs clinical utility is limited…”
Get full text