Search Results - "Hammer, RE"

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice by Hosoda, K, Hammer, R E, Richardson, J A, Baynash, A G, Cheung, J C, Giaid, A, Yanagisawa, M

“…Endothelins act on two subtypes of G protein-coupled receptors, termed endothelin-A and endothelin-B receptors. We report a targeted disruption of the mouse…”
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Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression by Taurog, JD, Maika, SD, Simmons, WA, Breban, M, Hammer, RE

“…To investigate the role of the class I MHC molecule HLA-B27 in the spondyloarthropathies, we produced rats transgenic for HLA-B27 and human beta…”
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Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking Pcsk9 by Rashid, Shirya, Curtis, David E., Garuti, Rita, Anderson, Norma N., Bashmakov, Yuriy, Ho, Y. K., Hammer, Robert E., Moon, Young-Ah, Horton, Jay D., Goldstein, Joseph L.

“…PCSK9 encodes proprotein convertase subtilisin/kexin type 9a (PCSK9), a member of the proteinase K subfamily of subtilases. Missense mutations in PCSK9 cause…”
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α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis by MISSLER, Markus, WEIQI ZHANG, ROHLMANN, Astrid, KATTENSTROTH, Gunnar, HAMMERT, Robert E, GOTTMANN, Kurt, SÜDHOF, Thomas C

“…Synapses are specialized intercellular junctions in which cell adhesion molecules connect the presynaptic machinery for neurotransmitter release to the…”
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Modulation of Synaptic Plasticity and Memory by Reelin Involves Differential Splicing of the Lipoprotein Receptor Apoer2 by Beffert, Uwe, Weeber, Edwin J., Durudas, Andre, Qiu, Shenfeng, Masiulis, Irene, Sweatt, J. David, Li, Wei-Ping, Adelmann, Giselind, Frotscher, Michael, Hammer, Robert E., Herz, Joachim

“…Apolipoprotein E receptor 2 (Apoer2), a member of the LDL receptor gene family, and its ligand Reelin control neuronal migration during brain development…”
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Disruption of Abcg5 and Abcg8 in Mice Reveals Their Crucial Role in Biliary Cholesterol Secretion by Yu, Liqing, Hammer, Robert E., Li-Hawkins, Jia, von Bergmann, Klaus, Lutjohann, Dieter, Cohen, Jonathan C., Hobbs, Helen H.

“…Cholesterol and other sterols exit the body primarily by secretion into bile. In patients with sitosterolemia, mutations in either of two ATP-binding cassette…”
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Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice by Shimomura, I, Matsuda, M, Hammer, R E, Bashmakov, Y, Brown, M S, Goldstein, J L

“…In mice with too little fat (lipodystrophy) or too much fat (ob/ob), leptin deficiency leads to hyperglycemia, hyperinsulinemia, and insulin resistance. In…”
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Double-Knockout Mice for α- and β-Synucleins: Effect on Synaptic Functions by Chandra, Sreeganga, Fornai, Francesco, Kwon, Hyung-Bae, Yazdani, Umar, Atasoy, Deniz, Liu, Xinran, Hammer, Robert E., Battaglia, Giuseppe, German, Dwight C., Castillo, Pablo E., Südhof, Thomas C.

“…An abundant presynaptic protein, α-synuclein, is centrally involved in the pathogenesis of Parkinson's disease. However, conflicting data exist about the…”
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Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo by Kisanuki, Yaz Y, Hammer, Robert E, Miyazaki, Jun-ichi, Williams, S.Clay, Richardson, James A, Yanagisawa, Masashi

“…Endocardial cells are thought to contribute at least in part to the formation of the endocardial cushion mesenchyme. Here, we created Tie2-Cre transgenic mice,…”
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Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c by Liang, Guosheng, Yang, Jian, Horton, Jay D., Hammer, Robert E., Goldstein, Joseph L., Brown, Michael S.

“…Two treatments, fasting/refeeding and administration of liver X receptor (LXR) agonists, elevate the mRNA for sterol regulatory element-binding protein-1c…”
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Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice: Molecular Genetic Dissection of Non-REM and REM Sleep Regulatory Processes by Willie, Jon T., Chemelli, Richard M., Sinton, Christopher M., Tokita, Shigeru, Williams, S.Clay, Kisanuki, Yaz Y., Marcus, Jacob N., Lee, Charlotte, Elmquist, Joel K., Kohlmeier, Kristi A., Leonard, Christopher S., Richardson, James A., Hammer, Robert E., Yanagisawa, Masashi

“…Narcolepsy-cataplexy, a neurological disorder associated with the absence of hypothalamic orexin (hypocretin) neuropeptides, consists of two underlying…”
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Critical Roles of the Guanylyl Cyclase B Receptor in Endochondral Ossification and Development of Female Reproductive Organs by Tamura, Naohisa, Doolittle, Lynda K., Hammer, Robert E., Shelton, John M., Richardson, James A., Garbers, David L.

“…Guanylyl cyclase B is the receptor for a small peptide (C-type natriuretic peptide) produced locally in many different tissues. To unravel the functions of the…”
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Hyperactivated Sperm Motility Driven by CatSper2 Is Required for Fertilization by Quill, Timothy A., Sugden, Sarah A., Rossi, Kristen L., Doolittle, Lynda K., Hammer, Robert E., Garbers, David L.

“…Elevations of sperm Ca2+seem to be responsible for an asymmetric form of motility called hyperactivation, which is first seen near the time of fertilization…”
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Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis by Engelking, Luke J., Kuriyama, Hiroshi, Hammer, Robert E., Horton, Jay D., Brown, Michael S., Goldstein, Joseph L., Liang, Guosheng

“…In the current studies we generated transgenic mice that overexpress human Insig-1 in the liver under a constitutive promoter. In cultured cells Insig-1 and…”
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Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy by Shimomura, I, Hammer, R.E, Ikemoto, S, Brown, M.S, Goldstein, J.L

“…Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by a paucity of adipose (fat) tissue which is evident at birth…”
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Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice by Johnson, Eric B., Hammer, Robert E., Herz, Joachim

“…Megf7/Lrp4 is a member of the functionally diverse low-density lipoprotein receptor gene family, a class of ancient and highly conserved cell surface receptors…”
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Self Renewal, Expansion, and Transfection of Rat Spermatogonial Stem Cells in Culture by Hamra, F. Kent, Chapman, Karen M., Derek M. Nguyen, Ashley A. Williams-Stephens, Hammer, Robert E., Garbers, David L.

“…The use of a transgenic line of rats that express enhanced GFP (EGFP) exclusively in the germ line has allowed a separation of feeder layers and contaminating…”
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Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels by Zhang, Weiqi, Rohlmann, Astrid, Sargsyan, Vardanush, Aramuni, Gayane, Hammer, Robert E, Südhof, Thomas C, Missler, Markus

“…Neurexins constitute a large family of highly variable cell-surface molecules that may function in synaptic transmission and/or synapse formation. Each of the…”
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Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2 by Trommsdorff, Marion, Gotthardt, Michael, Hiesberger, Thomas, Shelton, John, Stockinger, Walter, Nimpf, Johannes, Hammer, Robert E, Richardson, James A, Herz, Joachim

“…Layering of neurons in the cerebral cortex and cerebellum requires Reelin, an extracellular matrix protein, and mammalian Disabled (mDab1), a cytosolic protein…”
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Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins by Engelking, Luke J, Liang, Guosheng, Hammer, Robert E, Takaishi, Kiyosumi, Kuriyama, Hiroshi, Evers, Bret M, Li, Wei-Ping, Horton, Jay D, Goldstein, Joseph L, Brown, Michael S

“…End-product feedback inhibition of cholesterol synthesis was first demonstrated in living animals by Schoenheimer 72 years ago. Current studies define Insig…”
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