Search Results - "Hammad, Maha M"
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SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains
Published in PloS one (25-05-2021)“…COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly…”
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Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes
Published in Scientific reports (10-04-2020)“…Myeloperoxidase (MPO) is positively associated with obesity and diet-induced insulin resistance. Angiopoietin-like protein 6 (ANGPTL6) regulates metabolic…”
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Increased LRG1 Levels in Overweight and Obese Adolescents and Its Association with Obesity Markers, Including Leptin, Chemerin, and High Sensitivity C-Reactive Protein
Published in International journal of molecular sciences (02-08-2022)“…Leucine-rich α-2 glycoprotein1 (LRG1) is a member of the leucine-rich repeat (LRR) family that is implicated in multiple diseases, including cancer, aging, and…”
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Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism
Published in Frontiers in pharmacology (09-12-2020)“…COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus-2, which has infected over thirty eight million individuals worldwide. Emerging evidence…”
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5
LRG1 Associates with Iron Deficiency Anemia Markers in Adolescents
Published in Nutrients (01-07-2023)“…Leucine-rich α-2 glycoprotein1 (LRG1) has been shown to be associated with several health conditions; however, its association with iron deficiency anemia,…”
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MAGI proteins can differentially regulate the signaling pathways of 5-HT 2A R by enhancing receptor trafficking and PLC recruitment
Published in Cellular signalling (01-07-2018)“…MAGI proteins are Membrane-Associated Guanylate Kinase Inverted proteins that belong to the MAGUK family. They are scaffolding proteins that were shown to…”
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Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait
Published in Frontiers in endocrinology (Lausanne) (20-10-2023)“…Vitamin D deficiency (VDD) is widespread in the Arab world despite ample sunshine throughout the year. In our previous study, lifestyle and socio-demographic…”
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The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians
Published in Frontiers in endocrinology (Lausanne) (04-10-2023)“…The Wolfram syndrome 1 gene ( WFS1) is the main causative locus for Wolfram syndrome, an inherited condition characterized by childhood-onset diabetes…”
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Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance
Published in Metabolites (01-03-2023)“…Efficient signal transduction is important in maintaining the function of the nervous system across tissues. An intact neurotransmission process can regulate…”
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Adolescent obesity and ANGPTL8: correlations with high sensitivity C-reactive protein, leptin, and chemerin
Published in Frontiers in endocrinology (Lausanne) (2023)“…Angiopoietin-like proteins (ANGPTLs) mediate many metabolic functions. We had recently reported increased plasma levels of ANGPTL8 in obese adults of Arab…”
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Profiling of Insulin-Like Growth Factor Binding Proteins (IGFBPs) in Obesity and Their Association With Ox-LDL and Hs-CRP in Adolescents
Published in Frontiers in endocrinology (Lausanne) (28-07-2021)“…Insulin-like growth factor binding proteins (IGFBPs) are critical modulators of metabolism. In adults, IGFBPs are associated with obesity and insulin…”
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Potential Role of N-Cadherin in Diagnosis and Prognosis of Diabetic Nephropathy
Published in Frontiers in endocrinology (Lausanne) (31-05-2022)“…Diabetic nephropathy (DN) is a serious complication of diabetes affecting about half the people with diabetes and the leading cause of end stage renal disease…”
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MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort
Published in Frontiers in endocrinology (Lausanne) (07-07-2020)“…Melanocortin 4 receptor (MC4R), a notable component of the melanocortin system, regulates appetite, body weight, and energy homeostasis. Genome-wide…”
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Structural analysis of setmelanotide binding to MC4R variants in comparison to wild-type receptor
Published in Life sciences (1973) (15-10-2022)“…Melanocortin 4 receptor (MC4R) has a well-established role in regulating appetite, food intake and energy homeostasis. Setmelanotide is an MC4R agonist…”
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15
Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approach
Published in Microbial pathogenesis (01-09-2022)“…Neuropilin-1 (NRP1) is a widely expressed cell surface receptor protein characterized by its pleiotropic function. Recent reports highlighted NRP1 as an…”
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Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents
Published in Scientific reports (14-04-2020)“…Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to…”
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MAGI proteins can differentially regulate the signaling pathways of 5-HT2AR by enhancing receptor trafficking and PLC recruitment
Published in Cellular signalling (01-07-2018)“…MAGI proteins are Membrane-Associated Guanylate Kinase Inverted proteins that belong to the MAGUK family. They are scaffolding proteins that were shown to…”
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18
Role of cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) in regulating the trafficking and signaling of corticotropin-releasing factor receptor 1
Published in Cellular signalling (01-10-2015)“…Corticotropin releasing factor (CRF) receptor1 (CRFR1) is associated with psychiatric illness and is a proposed target for the treatment of anxiety and…”
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Na+/H+ Exchanger Regulatory Factor-1 Is Involved in Chemokine Receptor Homodimer CCR5 Internalization and Signal Transduction but Does Not Affect CXCR4 Homodimer or CXCR4-CCR5 Heterodimer
Published in The Journal of biological chemistry (05-11-2010)“…Chemokine receptors are members of the G protein-coupled receptor (GPCR) family. CCR5 is also the principal co-receptor for macrophage-tropic strains of human…”
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Rab1 interacts directly with the β2-adrenergic receptor to regulate receptor anterograde trafficking
Published in Biological chemistry (01-06-2012)“…Very little is understood about the trafficking of G protein-coupled receptors (GPCRs) from the endoplasmic reticulum (ER) to the plasma membrane. Rab…”
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