Search Results - "Hamm, Jon"

Characterizing sources of variability in zebrafish embryo screening protocols by Hamm, Jon T, Ceger, Patricia, Allen, David, Stout, Matt, Maull, Elizabeth A, Baker, Greg, Zmarowski, Amy, Padilla, Stephanie, Perkins, Edward, Planchart, Antonio, Stedman, Donald, Tal, Tamara, Tanguay, Robert L, Volz, David C, Wilbanks, Mitch S, Walker, Nigel J

“…There is a need for fast, efficient, and cost-effective hazard identification and characterization of chemical hazards. This need is generating increased…”
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Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Developing a Data Analysis Pipeline for the Assessment of Developmental Toxicity with an Interlaboratory Study by Hsieh, Jui-Hua, Nolte, Sue, Hamm, Jon T, Wang, Zicong, Roberts, Georgia K, Schmitt, Charles P, Ryan, Kristen R

“…The embryonic zebrafish is a useful vertebrate model for assessing the effects of substances on growth and development. However, cross-laboratory developmental…”
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Interlaboratory Study on Zebrafish in Toxicology: Systematic Evaluation of the Application of Zebrafish in Toxicology's (SEAZIT's) Evaluation of Developmental Toxicity by Hamm, Jon T, Hsieh, Jui-Hua, Roberts, Georgia K, Collins, Bradley, Gorospe, Jenni, Sparrow, Barney, Walker, Nigel J, Truong, Lisa, Tanguay, Robyn L, Dyballa, Sylvia, Miñana, Rafael, Schiavone, Valentina, Terriente, Javier, Weiner, Andrea, Muriana, Arantza, Quevedo, Celia, Ryan, Kristen R

“…Embryonic zebrafish represent a useful test system to screen substances for their ability to perturb development. The exposure scenarios, endpoints captured,…”
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Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays by Hamm, Jon, Mahapatra, Debabrata, Knuth, Megan M., Abedini, Jaleh, Lingerfelt, Mary, Ekins, Sean, Kullman, Seth W.

“…[Display omitted] •High throughput screening of chemicals identified a diverse array of FXR agonists and antagonists.•FXR agonists and antagonists identified…”
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Implementation of Zebrafish Ontologies for Toxicology Screening by Thessen, Anne E, Marvel, Skylar, Achenbach, J C, Fischer, Stephan, Haendel, Melissa A, Hayward, Kimberly, Klüver, Nils, Könemann, Sarah, Legradi, Jessica, Lein, Pamela, Leong, Connor, Mylroie, J Erik, Padilla, Stephanie, Perone, Dante, Planchart, Antonio, Prieto, Rafael Miñana, Muriana, Arantza, Quevedo, Celia, Reif, David, Ryan, Kristen, Stinckens, Evelyn, Truong, Lisa, Vergauwen, Lucia, Vom Berg, Colette, Wilbanks, Mitch, Yaghoobi, Bianca, Hamm, Jon

“…Toxicological evaluation of chemicals using early-life stage zebrafish ( ) involves the observation and recording of altered phenotypes. Substantial…”
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Characterizing sources of variability in zebrafish embryo screening protocols_suppl by Hamm, Jon

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Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity by Hamm, Jon, Allen, David, Ceger, Patricia, Flint, Tara, Lowit, Anna, O'Dell, Lindsay, Tao, Jenny, Kleinstreuer, Nicole

“…Acute oral toxicity classifications are based on the estimated chemical dose causing lethality in 50 % of laboratory animals tested (LD50). Given the large…”
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Strengths and limitations of the worm development and activity test (wDAT) as a chemical screening tool for developmental hazards by Hunt, Piper Reid, Welch, Bonnie, Camacho, Jessica, Salazar, Joelle K., Fay, Megan L., Hamm, Jon, Ceger, Patricia, Allen, Dave, Fitzpatrick, Suzanne C., Yourick, Jeffrey, Sprando, Robert L.

“…The worm Development and Activity Test (wDAT) measures C. elegans developmental milestone acquisition timing and stage-specific spontaneous locomotor activity…”
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Standardizing Extracted Data Using Automated Application of Controlled Vocabularies by Foster, Caroline, Wignall, Jessica, Kovach, Samuel, Choksi, Neepa, Allen, Dave, Trgovcich, Joanne, Rochester, Johanna R, Ceger, Patricia, Daniel, Amber, Hamm, Jon, Truax, Jim, Blake, Bevin, McIntyre, Barry, Sutherland, Vicki, Stout, Matthew D, Kleinstreuer, Nicole

“…Extraction of toxicological end points from primary sources is a central component of systematic reviews and human health risk assessments. To ensure optimal…”
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Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor by Hsu, Chia-Wen, Zhao, Jinghua, Huang, Ruili, Hsieh, Jui-Hua, Hamm, Jon, Chang, Xiaoqing, Houck, Keith, Xia, Menghang

“…The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids and glucose. Because endogenous chemicals bind and activate FXR, it is important…”
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Evaluation of the fish acute toxicity test for pesticide registration by Ceger, Patricia, Allen, David, Blankinship, Amy, Choksi, Neepa, Daniel, Amber, Eckel, William P., Hamm, Jon, Harwood, D. Ethan, Johnson, Tamara, Kleinstreuer, Nicole, Sprankle, Catherine S., Truax, James, Lowit, Michael

“…The U.S. Environmental Protection Agency (USEPA) uses the in vivo fish acute toxicity test to assess potential risk of substances to non-target aquatic…”
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Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing by Hamm, Jon, Sullivan, Kristie, Clippinger, Amy J., Strickland, Judy, Bell, Shannon, Bhhatarai, Barun, Blaauboer, Bas, Casey, Warren, Dorman, David, Forsby, Anna, Garcia-Reyero, Natàlia, Gehen, Sean, Graepel, Rabea, Hotchkiss, Jon, Lowit, Anna, Matheson, Joanna, Reaves, Elissa, Scarano, Louis, Sprankle, Catherine, Tunkel, Jay, Wilson, Dan, Xia, Menghang, Zhu, Hao, Allen, David

“…Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed…”
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Advancing toxicology research using in vivo high throughput toxicology with small fish models by Planchart, Antonio, Mattingly, Carolyn J, Allen, David, Ceger, Patricia, Casey, Warren, Hinton, David, Kanungo, Jyotshna, Kullman, Seth W, Tal, Tamara, Bondesson, Maria, Burgess, Shawn M, Sullivan, Con, Kim, Carol, Behl, Mamta, Padilla, Stephanie, Reif, David M, Tanguay, Robert L, Hamm, Jon

“…Small freshwater fish models, especially zebrafish, offer advantages over traditional rodent models, including low maintenance and husbandry costs, high…”
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Differential modulation of FXR activity by chlorophacinone and ivermectin analogs by Hsu, Chia-Wen, Hsieh, Jui-Hua, Huang, Ruili, Pijnenburg, Dirk, Khuc, Thai, Hamm, Jon, Zhao, Jinghua, Lynch, Caitlin, van Beuningen, Rinie, Chang, Xiaoqing, Houtman, René, Xia, Menghang

“…Chemicals that alter normal function of farnesoid X receptor (FXR) have been shown to affect the homeostasis of bile acids, glucose, and lipids. Several…”
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Converts to The Church by Hamm, Jon

“…Hamm talks about Bull Durham, one of his alltime favorite sports movies. He also mentions one of his greatest childhood memories and his most exhilarating…”
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Your content is dead to me: genuine and meaningful communication with consumers must include their narrative participation. Otherwise it's just static by Hamm, Jon

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Voice: Your Content Is Dead to Me by Hamm, Jon

“…To build on the opportunities that today's hyperconnected and social consumer as well as new distribution platforms offer, agencies and brands need to move…”
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The connected protagonist: to reach the highly strategic, content-hungry consumer, marketers need to shift their own role from star to supporting player by Hamm, Jon

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Voice: The Connected Protagonist by Hamm, Jon

“…The fusion of the social economy and the digital communications world has created an environment from which a new generation of consumer -- the Connected…”
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