Search Results - "Hamm, E"

Heterotrimeric G protein activation by G-protein-coupled receptors by Hamm, Heidi E, Oldham, William M

“…Key Points G-protein-coupled receptors (GPCRs) represent one of the largest and most diverse groups of proteins in the genome. Activated receptors catalyse…”
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Structural basis of function in heterotrimeric G proteins by Oldham, William M, Hamm, Heidi E

“…Heterotrimeric guanine-nucleotide-binding proteins (G proteins) act as molecular switches in signaling pathways by coupling the activation of heptahelical…”
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Conformational Flexibility and Structural Dynamics in GPCR-Mediated G Protein Activation: A Perspective by Preininger, Anita M., Meiler, Jens, Hamm, Heidi E.

“…Structure and dynamics of G proteins and their cognate receptors, both alone and in complex, are becoming increasingly accessible to experimental techniques…”
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The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia by Rajala, Hanna L M, Olson, Thomas, Clemente, Michael J, Lagström, Sonja, Ellonen, Pekka, Lundan, Tuija, Hamm, David E, Zaman, Syed Arshi Uz, Lopez Marti, Jesus M, Andersson, Emma I, Jerez, Andres, Porkka, Kimmo, Maciejewski, Jaroslaw P, Loughran, Thomas P, Mustjoki, Satu

“…T-cell large granular lymphocytic leukemia and chronic lymphoproliferative disorder of natural killer cells are intriguing entities between benign and…”
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Older Patient and Caregiver Perspectives on Medication Value and Deprescribing: A Qualitative Study by Pickering, Aimee N., Hamm, Megan E., Dawdani, Alicia, Hanlon, Joseph T., Thorpe, Carolyn T., Gellad, Walid F., Radomski, Thomas R.

“…OBJECTIVES Shared decision making is essential to deprescribing unnecessary or harmful medications in older adults, yet patients' and caregivers' perspectives…”
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How Activated Receptors Couple to G Proteins by Hamm, Heidi E.

“…G protein-coupled receptors (GPCRs) are involved in the control of every aspect of our behavior and physiology. This is the largest class of receptors, with…”
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Architecture and material properties of diatom shells provide effective mechanical protection by Hamm, Christian E, Merkel, Rudolf, Springer, Olaf, Jurkojc, Piotr, Maier, Christian, Prechtel, Kathrin, Smetacek, Victor

“…Diatoms are the major contributors to phytoplankton blooms in lakes and in the sea and hence are central in aquatic ecosystems and the global carbon cycle. All…”
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Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity by Ceddia, Ryan P, Zurawski, Zack, Thompson Gray, Analisa, Adegboye, Feyisayo, McDonald-Boyer, Ainsley, Shi, Fubiao, Liu, Dianxin, Maldonado, Jose, Feng, Jiesi, Li, Yulong, Alford, Simon, Ayala, Julio E, McGuinness, Owen P, Collins, Sheila, Hamm, Heidi E

“…Negative regulation of exocytosis from secretory cells is accomplished through inhibitory signals from Gi/o GPCRs by Gβγ subunit inhibition of 2 mechanisms:…”
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Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit by Van Eps, Ned, Preininger, Anita M, Alexander, Nathan, Kaya, Ali I, Meier, Scott, Meiler, Jens, Hamm, Heidi E, Hubbell, Wayne L

“…In G-protein signaling, an activated receptor catalyzes GDP/GTP exchange on the Gα subunit of a heterotrimeric G protein. In an initial step, receptor…”
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Phototransduction in retinal cones: Analysis of parameter importance by Klaus, Colin, Caruso, Giovanni, Gurevich, Vsevolod V, Hamm, Heidi E, Makino, Clint L, DiBenedetto, Emmanuele

“…In daylight, cone photoreceptors in the retina are responsible for the bulk of visual perception, yet compared to rods, far less is known quantitatively about…”
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Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa by Lokits, A D, Indrischek, H, Meiler, J, Hamm, H E, Stadler, P F

“…Heterotrimeric G proteins are fundamental signaling proteins composed of three subunits, Gα and a Gβγ dimer. The role of Gα as a molecular switch is critical…”
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High PD-L1/CD86 MFI ratio and IL-10 secretion characterize human regulatory dendritic cells generated for clinical testing in organ transplantation by Zahorchak, Alan F., Macedo, Camila, Hamm, David E., Butterfield, Lisa H., Metes, Diana M., Thomson, Angus W.

“…•GMP grade regulatory dendritic cells can be generated from human blood monocytes in adequate numbers for systemic infusion.•DCreg exhibit high levels of PD-L1…”
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SNAP25 differentially contributes to Gi/o-coupled receptor function at glutamatergic synapses in the nucleus accumbens by Manz, Kevin M., Zepeda, José C., Zurawski, Zack, Hamm, Heidi E., Grueter, Brad A.

“…The nucleus accumbens (NAc) guides reward-related motivated behavior implicated in pathological behavioral states, including addiction and depression. These…”
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Position of rhodopsin photoisomerization on the disk surface confers variability to the rising phase of the single photon response in vertebrate rod photoreceptors by Caruso, Giovanni, Klaus, Colin J, Hamm, Heidi E, Gurevich, Vsevolod V, Makino, Clint L, DiBenedetto, Emmanuele

“…Retinal rods function as accurate photon counters to provide for vision under very dim light. To do so, rods must generate highly amplified, reproducible…”
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High-Dose Spinal Cord Stimulation for Treatment of Chronic Low Back Pain and Leg Pain in Patients With FBSS, 12-Month Results: A Prospective Pilot Study by Hamm-Faber, Tanja E, Gültuna, Ismail, van Gorp, Eric-Jan, Aukes, Hans

“…To investigate the long-term effect of high-dose spinal cord stimulation (HD-SCS) in patients with chronic refractory low back and leg pain due to failed back…”
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Views of patients suffering from Failed Back Surgery Syndrome on their health and their ability to adapt to daily life and self-management: A qualitative exploration by Hamm-Faber, Tanja E, Engels, Yvonne, Vissers, Kris C P, Henssen, Dylan J H A

“…The clinical outcomes of Spinal Cord Stimulation (SCS) therapy in patients with a Failed Back Surgery Syndrome (FBSS) is mostly done by standardized pain and…”
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The Many Faces of G Protein Signaling by Hamm, Heidi E.

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Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1 by McLaughlin, Joseph N., Shen, Lixin, Holinstat, Michael, Brooks, Joshua D., DiBenedetto, Emmanuele, Hamm, Heidi E.

“…Thrombin activates protease-activated receptor-1 (PAR-1) by cleavage of the amino terminus to unmask a tethered ligand. Although peptide analogs can activate…”
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High-throughput sequencing of islet-infiltrating memory CD4+ T cells reveals a similar pattern of TCR Vβ usage in prediabetic and diabetic NOD mice by Marrero, Idania, Hamm, David E, Davies, Joanna D

“…Autoreactive memory CD4(+) T cells play a critical role in the development of type 1 diabetes, but it is not yet known how the clonotypic composition and TCRβ…”
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Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat in Snord116m+/p− and Snord116m−/p− Mouse Models of Prader–Willi Syndrome by Knott, Brittney, Kocher, Matthew A., Paz, Henry A., Hamm, Shelby E., Fink, William, Mason, Jordan, Grange, Robert W., Wankhade, Umesh D., Good, Deborah J.

“…Prader–Willi Syndrome (PWS) is a human genetic condition that affects up to 1 in 10,000 live births. Affected infants present with hypotonia and developmental…”
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