Search Results - "Hamlyn, J M"

Endogenous ouabain and cardiomyopathy in dialysis patients by Stella, P., Manunta, P., Mallamaci, F., Melandri, M., Spotti, D., Tripepi, G., Hamlyn, J. M., Malatino, L. S., Bianchi, G., Zoccali, C.

“… Background and methods.  Endogenous ouabain (EO) is markedly raised in patients with chronic renal failure. As high EO induces myocardial cell hypertrophy in…”
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Identification and Characterization of a Ouabain-Like Compound from Human Plasma by Hamlyn, J. M., Blaustein, M. P., Bova, S., DuCharme, D. W., Harris, D. W., Mandel, F., Mathews, W. R., Ludens, J. H.

“…The plasma membrane sodium-potassium pumps that regulate intracellular sodium in most animal cells have specific, high-affinity receptors for the digitalis…”
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Left Ventricular Mass, Stroke Volume, and Ouabain-Like Factor in Essential Hypertension by Manunta, Paolo, Stella, Paola, Rivera, Rodolfo, Ciurlino, Daniele, Cusi, Daniele, Ferrandi, Mara, Hamlyn, John M, Bianchi, Giuseppe

“…Many patients with essential hypertension (EH) exhibit increased left ventricular mass. Similarly, elevated circulating levels of an endogenous ouabainlike…”
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Ouabain-like Factor Quantification in Mammalian Tissues and Plasma: Comparison of Two Independent Assays by Ferrandi, Mara, Manunta, Paolo, Balzan, Silvana, Hamlyn, John M, Bianchi, Giuseppe, Ferrari, Patrizia

“…The resolution of controversies that concern the detectability of an endogenous ouabain-like factor (OLF) in mammalian tissues and plasma was approached by the…”
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Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis by Hamlyn, J M, Hamilton, B P, Manunta, P

“…To assess possible relationships between endogenous ouabain, sodium balance and blood pressure. This review concerns the structure of endogenous ouabain,…”
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Long-term Ouabain Administration Produces Hypertension in Rats by Yuan, Christina M, Manunta, Paolo, Hamlyn, John M, Chen, Shanwan, Bohen, Erin, Yeun, Jane, Haddy, Francis J, Pamnani, Motilal B

“…Ouabain has recently been identified as an endogenous Na -K pump inhibitor. We administered ouabain chronically to normotensive rats with varying degrees of…”
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Ouabain is secreted by bovine adrenocortical cells by Laredo, J, Hamilton, B P, Hamlyn, J M

“…Ouabain is a specific inhibitor of the sodium pump. This steroid has been found in the mammalian circulation in significant amounts and may be of adrenal…”
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Ouabain, digitalis-like factors and hypertension by Hamlyn, J M, Manunta, P

“…To review the evidence that ouabain and other digitalis-like factors are present in the human circulation under normal circumstances and in various disorders…”
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Chronic Hypertension Induced by Ouabain but Not Digoxin in the Rat: Antihypertensive Effect of Digoxin and Digitoxin by MANUNTA, Paolo, HAMILTON, James, ROGOWSKI, Amy C., HAMILTON, Bruce P., HAMLYN, John M.

“…Elevated circulating levels of an endogenous ouabain (EO) have been associated with essential hypertension. To investigate structure-activity relationships…”
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Ouabain is secreted by the adrenal gland in awake dogs by Boulanger, B R, Lilly, M P, Hamlyn, J M, Laredo, J, Shurtleff, D, Gann, D S

“…Ouabain has been identified in the plasma and adrenal glands of several mammals, including humans. To investigate possible adrenal secretion of ouabain in…”
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Immunoreactive endogenous ouabain in primary aldosteronism and essential hypertension: relationship with plasma renin, aldosterone and blood pressure levels by Rossi, G, Manunta, P, Hamlyn, J M, Pavan, E, De Toni, R, Semplicini, A, Pessina, A C

“…To investigate the role of ouabain in human hypertension and to establish whether immunoreactive endogenous ouabain is secreted by the adrenal gland under the…”
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Ouabain-induced hypertension in the rat: relationships among plasma and tissue ouabain and blood pressure by Manunta, P, Rogowski, A C, Hamilton, B P, Hamlyn, J M

“…To determine the steady-state dose-dependence of blood pressure, plasma and tissue ouabain during continuous infusion of ouabain in the rat, and to evaluate…”
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Elevated concentrations of endogenous ouabain in patients with congestive heart failure by GOTTLIEB, S. S, ROGOWSKI, A. C, WEINBERG, M, KRICHTEN, C. M, HAMILTON, B. P, HAMLYN, J. M

“…An endogenous digitalis-like compound in mammals has long been postulated, but only recently has a substance indistinguishable from ouabain been identified in…”
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Observations on the Nature, Biosynthesis, Secretion and Significance of Endogenous Ouabain by Hamlyn, John M., Lu, Zhuo-Ren, Manunta, Paolo, Ludens, James H., Kimura, Keizo, Shah, Jui R., Laredo, James, Hamilton, James P., Hamilton, Matthew J., Hamilton, Bruce P.

“…The human circulation contains four readily distinguishable biologically active inhibitors of the sodium pump that appear to be endogenous to mammals. Of…”
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Mass Spectral Characterization of an Endogenous Digitalislike Factor From Human Plasma by Mathews, W Rodney, DuCharme, Donald W, Hamlyn, John M, Harris, Douglas W, Mandel, Frederic, Clark, Michael A, Ludens, James H

“…A sodium pump inhibitor has been isolated from human plasma and extensively purified. This material, endogenous digitalislike factor, was examined by a variety…”
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Digitalis-like activity in human plasma. Purification, affinity, and mechanism by HAMLYN, J. M, HARRIS, D. W, LUDENS, J. H

“…A factor having digitalis-like characteristics has been isolated from human plasma and its mechanism of action compared with the commonly used cardenolide,…”
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Different signaling pathways mediate stimulated secretions of endogenous ouabain and aldosterone from bovine adrenocortical cells by SHAH, J. R, LAREDO, J, HAMILTON, B. P, HAMLYN, J. M

“…Angiotensin II stimulates secretion of corticosteroids and an ouabain-like compound from adrenocortical cells. The angiotensin AT1 and AT2 receptor subtypes…”
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Effects of Angiotensin II on Sodium Potassium Pumps, Endogenous Ouabain, and Aldosterone in Bovine Zona Glomerulosa Cells by Shah, Jui R, Laredo, James, Hamilton, Bruce P, Hamlyn, John M

“…Angiotensin (Ang) II stimulates secretions of aldosterone and an endogenous ouabain-like steroid (EO) from bovine adrenal zona glomerulosa (BAG) cells. The BAG…”
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Increased levels of a humoral digitalis-like factor in deoxycorticosterone acetate-induced hypertension in the pig by Hamlyn, J M

“…Plasma levels of an endogenous digitalis-like factor (EDLF) and atrial peptides were followed in pigs confined to metabolic cages during the development of…”
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Purification of an Endogenous Digitalislike Factor From Human Plasma for Structural Analysis by Ludens, James H, Clark, Michael A, DuChanne, Donald W, Harris, Douglas W, Lutzke, Barry S, Mandel, Frederic, Mathews, W Rodney, Sutter, Dorothy M, Hamlyn, John M

“…In previous reports, we described the isolation and characterization of an endogenous digitalislike factor (EDLF). In this report, we describe a unique…”
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