Search Results - "Hamlett, Eric D"

Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer's disease by Watson, Luke S, Hamlett, Eric D, Stone, Tyler D, Sims-Robinson, Catrina

“…In order for Alzheimer's disease (AD) to manifest, cells must communicate "pathogenic material" such as proteins, signaling molecules, or genetic material to…”
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Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease by Li, Pengfei, Wu, Yan, Hamlett, Eric D., Goodwin, Andrew J., Halushka, Perry V., Carroll, Steven L., Liu, Meng, Fan, Hongkuan

“…Brain pericytes regulate cerebral blood flow, maintain the integrity of the blood-brain barrier (BBB), and facilitate the removal of amyloid β (Aβ), which is…”
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RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome by Hamlett, Eric D., Hjorth, Erik, Ledreux, Aurélie, Gilmore, Anah, Schultzberg, Marianne, Granholm, Ann Charlotte

“…Inflammation can be resolved by pro‐homeostatic lipids called specialized pro‐resolving mediators (SPMs) upon activation of their receptors. Dysfunctional…”
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Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome by Hamlett, Eric D, Goetzl, Edward J, Ledreux, Aurélie, Vasilevko, Vitaly, Boger, Heather A, LaRosa, Angela, Clark, David, Carroll, Steven L, Carmona-Iragui, María, Fortea, Juan, Mufson, Elliott J, Sabbagh, Marwan, Mohammed, Abdul H, Hartley, Dean, Doran, Eric, Lott, Ira T, Granholm, Ann-Charlotte

“…Abstract Introduction Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD…”
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Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome by Hamlett, Eric D., Ledreux, Aurélie, Gilmore, Anah, Vazey, Elena M., Aston-Jones, Gary, Boger, Heather A., Paredes, Daniel, Granholm, Ann-Charlotte E.

“…The pontine nucleus locus coeruleus (LC) is the primary source of noradrenergic (NE) projections to the brain and is important for working memory, attention,…”
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Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome by Hamlett, Eric D, Boger, Heather A, Ledreux, Aurélie, Kelley, Christy M, Mufson, Elliott J, Falangola, Maria F, Guilfoyle, David N, Nixon, Ralph A, Patterson, David, Duval, Nathan, Granholm, Ann-Charlotte E

“…Down syndrome (DS) is the most common non-lethal genetic condition that affects approximately 1 in 700 births in the United States of America. DS is…”
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Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain by Luo, Zhenwu, Fitting, Sylvia, Robinson, Catrina, Benitez, Andreana, Li, Min, Wu, Yongxia, Fu, Xiaoyu, Amato, Davide, Ning, Wangbin, Funderburg, Nicholas, Wang, Xu, Zhou, Zejun, Yu, Xuezhong, Wagner, Amanda, Cong, Xiaomei, Xu, Wanli, Maas, Kendra, Wolf, Bethany J., Huang, Lei, Yu, Jeremy, Scott, Alison, Mcrae-Clark, Aimee, Hamlett, Eric D., Jiang, Wei

“…Little is known about chronic cannabis smoking-associated oral microbiome and its effects on central nervous system (CNS) functions. In the current study, we…”
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Unveiling the Intricate Link Between Anaerobe Niche and Alzheimer Disease Pathogenesis by Drakes, NyEmma, Kondrikova, Galina, Pytel, Dariusz, Hamlett, Eric D

“…Abstract Dysbiosis within microbiomes has been increasingly implicated in many systemic illnesses, such as cardiovascular disease, metabolic syndrome,…”
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Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome by Saternos, Hannah, Hamlett, Eric D, Guzman, Samuel, Head, Elizabeth, Granholm, Ann-Charlotte, Ledreux, Aurélie

“…Down syndrome (DS) is one of the most commonly occurring chromosomal conditions. Most individuals with DS develop Alzheimer's disease (AD) by 50 years of age…”
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p38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia by Lin, Houmin, Dixon, Steven Grant, Hu, Wei, Hamlett, Eric D., Jin, Junfei, Ergul, Adviye, Wang, Gavin Y.

“…The accumulation of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer’s disease (AD) pathology. Microglial activation-mediated…”
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Exosomal biomarkers in Down syndrome and Alzheimer's disease by Hamlett, Eric D., Ledreux, Aurélie, Potter, Huntington, Chial, Heidi J., Patterson, David, Espinosa, Joaquin M., Bettcher, Brianne M., Granholm, Ann-Charlotte

“…Every person with Down syndrome (DS) has the characteristic features of Alzheimer's disease (AD) neuropathology in their brain by the age of forty, and most go…”
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The Role of Tau Pathology in Alzheimer's Disease and Down Syndrome by Granholm, Ann-Charlotte, Hamlett, Eric D

“…: Individuals with Down syndrome (DS) exhibit an almost complete penetrance of Alzheimer's disease (AD) pathology but are underrepresented in clinical trials…”
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Locus coeruleus and dorsal cingulate morphology contributions to slowed processing speed by Eckert, Mark A., Iuricich, Federico, Harris, Kelly C., Hamlett, Eric D., Vazey, Elena M., Aston-Jones, Gary

“…Slowed information processing speed is a defining feature of cognitive aging. Nucleus locus coeruleus (LC) and medial prefrontal regions are targets for…”
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Greater Diffusion Restriction in White Matter in Preclinical Alzheimer Disease by Benitez, Andreana, Jensen, Jens H., Thorn, Kathryn, Dhiman, Siddhartha, Fountain‐Zaragoza, Stephanie, Rieter, William J., Spampinato, Maria Vittoria, Hamlett, Eric D., Nietert, Paul J., Falangola, Maria de Fatima, Helpern, Joseph A.

“…Objective The Alzheimer's continuum is biologically defined by beta‐amyloid deposition, which at the earliest stages is superimposed upon white matter…”
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Neuropathological findings in Down syndrome, Alzheimer’s disease and control patients with and without SARS-COV-2: preliminary findings by Granholm, Ann-Charlotte E., Englund, Elisabet, Gilmore, Anah, Head, Elizabeth, Yong, William H., Perez, Sylvia E., Guzman, Samuel J., Hamlett, Eric D., Mufson, Elliott J.

“…The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many patients, with an increased mortality…”
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Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress by Hiller, Sylvia, DeKroon, Robert, Hamlett, Eric D., Xu, Longquan, Osorio, Cristina, Robinette, Jennifer, Winnik, Witold, Simington, Stephen, Maeda, Nobuyo, Alzate, Oscar, Yi, Xianwen

“…S-nitrosylation of mitochondrial enzymes involved in energy transfer under nitrosative stress may result in ATP deficiency. We investigated whether α-lipoic…”
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Exosome release and cargo in Down syndrome by Hamlett, Eric D., LaRosa, Angela, Mufson, Elliott J., Fortea, Juan, Ledreux, Aurélie, Granholm, Ann‐Charlotte

“…Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have…”
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Down Syndrome Biobank Consortium: A perspective by Aldecoa, Iban, Barroeta, Isabel, Carroll, Steven L., Fortea, Juan, Gilmore, Anah, Ginsberg, Stephen D., Guzman, Samuel J., Hamlett, Eric D., Head, Elizabeth, Perez, Sylvia E., Potter, Huntington, Molina‐Porcel, Laura, Raha‐Chowdhury, Ruma, Wisniewski, Thomas, Yong, William H., Zaman, Shahid, Ghosh, Sujay, Mufson, Elliott J., Granholm, Ann‐Charlotte

“…Individuals with Down syndrome (DS) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early‐onset Alzheimer's disease…”
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Designer receptors enhance memory in a mouse model of Down syndrome by Fortress, Ashley M, Hamlett, Eric D, Vazey, Elena M, Aston-Jones, Gary, Cass, Wayne A, Boger, Heather A, Granholm, Ann-Charlotte E

“…Designer receptors exclusively activated by designer drugs (DREADDs) are novel and powerful tools to investigate discrete neuronal populations in the brain. We…”
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Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society by Hamlett, Eric D., Flores-Aguilar, Lisi, Handen, Benjamin, Potier, Marie-Claude, Granholm, Ann-Charlotte, Sherman, Stephanie, Puig, Maria Victoria, Santoro, Jonathan D., Carmona-Iragui, María Victoria, Rebillat, Anne-Sophie, Head, Elizabeth, Strydom, André, Busciglio, Jorge

“…Research focused on Down syndrome continued to gain momentum in the last several years and is advancing our understanding of how trisomy 21 (T21) modifies…”
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