Search Results - "Hamilton, William L"

Graph neural representational learning of RNA secondary structures for predicting RNA-protein interactions by Yan, Zichao, Hamilton, William L, Blanchette, Mathieu

“…RNA-protein interactions are key effectors of post-transcriptional regulation. Significant experimental and bioinformatics efforts have been expended on…”
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Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study by Meredith, Luke W, Hamilton, William L, Warne, Ben, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Curran, Martin D, Parmar, Surendra, Caller, Laura G, Caddy, Sarah L, Khokhar, Fahad A, Yakovleva, Anna, Hall, Grant, Feltwell, Theresa, Forrest, Sally, Sridhar, Sushmita, Weekes, Michael P, Baker, Stephen, Brown, Nicholas, Moore, Elinor, Popay, Ashley, Roddick, Iain, Reacher, Mark, Gouliouris, Theodore, Peacock, Sharon J, Dougan, Gordon, Török, M Estée, Goodfellow, Ian

“…The burden and influence of health-care associated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unknown. We aimed to examine the…”
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Augmented base pairing networks encode RNA-small molecule binding preferences by Oliver, Carlos, Mallet, Vincent, Gendron, Roman Sarrazin, Reinharz, Vladimir, Hamilton, William L, Moitessier, Nicolas, Waldispühl, Jérôme

“…Abstract RNA-small molecule binding is a key regulatory mechanism which can stabilize 3D structures and activate molecular functions. The discovery of…”
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Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis by Claessens, Antoine, Hamilton, William L, Kekre, Mihir, Otto, Thomas D, Faizullabhoy, Adnan, Rayner, Julian C, Kwiatkowski, Dominic

“…The most polymorphic gene family in P. falciparum is the ∼60 var genes distributed across parasite chromosomes, both in the subtelomeres and in internal…”
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Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres by Otto, Thomas D, Böhme, Ulrike, Sanders, Mandy, Reid, Adam, Bruske, Ellen I, Duffy, Craig W, Bull, Pete C, Pearson, Richard D, Abdi, Abdirahman, Dimonte, Sandra, Stewart, Lindsay B, Campino, Susana, Kekre, Mihir, Hamilton, William L, Claessens, Antoine, Volkman, Sarah K, Ndiaye, Daouda, Amambua-Ngwa, Alfred, Diakite, Mahamadou, Fairhurst, Rick M, Conway, David J, Franck, Matthias, Newbold, Chris I, Berriman, Matt

“…: Although thousands of clinical isolates of are being sequenced and analysed by short read technology, the data do not resolve the highly variable…”
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The impact of diagnostic microbiology on de-escalation of antimicrobial therapy in hospitalised adults by Hamilton, William L, Pires, Sacha-Marie, Lippett, Samantha, Gudka, Vikesh, Cross, Elizabeth L A, Llewelyn, Martin J

“…Minimising antimicrobial overuse is needed to limit antimicrobial resistance. There is little evidence on how often microbiological testing informs…”
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The role of viral genomics in understanding COVID-19 outbreaks in long-term care facilities by Aggarwal, Dinesh, Myers, Richard, Hamilton, William L, Bharucha, Tehmina, Tumelty, Niamh M, Brown, Colin S, Meader, Emma J, Connor, Tom, Smith, Darren L, Bradley, Declan T, Robson, Samuel, Bashton, Matthew, Shallcross, Laura, Zambon, Maria, Goodfellow, Ian, Chand, Meera, O'Grady, Justin, Török, M Estée, Peacock, Sharon J, Page, Andrew J

“…We reviewed all genomic epidemiology studies on COVID-19 in long-term care facilities (LTCFs) that had been published to date. We found that staff and…”
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Do local tobacco regulations influence perceived smoking norms? Evidence from adult and youth surveys in Massachusetts by Hamilton, William L., Biener, Lois, Brennan, Robert T.

“…Smoking behavior has been shown to be influenced by individuals’ perceptions of social norms about smoking. This study examines whether local regulations…”
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Optimized whole-genome amplification strategy for extremely AT-biased template by Oyola, Samuel O, Manske, Magnus, Campino, Susana, Claessens, Antoine, Hamilton, William L, Kekre, Mihir, Drury, Eleanor, Mead, Daniel, Gu, Yong, Miles, Alistair, MacInnis, Bronwyn, Newbold, Chris, Berriman, Matthew, Kwiatkowski, Dominic P

“…Pathogen genome sequencing directly from clinical samples is quickly gaining importance in genetic and medical research studies. However, low DNA yield from…”
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Language from police body camera footage shows racial disparities in officer respect by Voigt, Rob, Camp, Nicholas P., Prabhakaran, Vinodkumar, Hamilton, William L., Hetey, Rebecca C., Griffiths, Camilla M., Jurgens, David, Jurafsky, Dan, Eberhardt, Jennifer L.

“…Using footage from body-worn cameras, we analyze the respectfulness of police officer language toward white and black community members during routine traffic…”
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Public health interventions to protect against falsified medicines: a systematic review of international, national and local policies by Hamilton, William L., Doyle, Cormac, Halliwell-Ewen, Mycroft, Lambert, Gabriel

“…Abstract Background: Falsified medicines are deliberately fraudulent drugs that pose a direct risk to patient health and undermine healthcare systems, causing…”
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A review of biomedical datasets relating to drug discovery: a knowledge graph perspective by Bonner, Stephen, Barrett, Ian P, Ye, Cheng, Swiers, Rowan, Engkvist, Ola, Bender, Andreas, Hoyt, Charles Tapley, Hamilton, William L

“…Drug discovery and development is a complex and costly process. Machine learning approaches are being investigated to help improve the effectiveness and speed…”
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RNAglib: a python package for RNA 2.5 D graphs by Mallet, Vincent, Oliver, Carlos, Broadbent, Jonathan, Hamilton, William L, Waldispühl, Jérôme

“…Abstract Summary RNA 3D architectures are stabilized by sophisticated networks of (non-canonical) base pair interactions, which can be conveniently encoded as…”
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Vernal: a tool for mining fuzzy network motifs in RNA by Oliver, Carlos, Mallet, Vincent, Philippopoulos, Pericles, Hamilton, William L, Waldispühl, Jérôme

“…Abstract Motivation RNA 3D motifs are recurrent substructures, modeled as networks of base pair interactions, which are crucial for understanding…”
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Extreme mutation bias and high AT content in Plasmodium falciparum by Hamilton, William L, Claessens, Antoine, Otto, Thomas D, Kekre, Mihir, Fairhurst, Rick M, Rayner, Julian C, Kwiatkowski, Dominic

“…For reasons that remain unknown, the Plasmodium falciparum genome has an exceptionally high AT content compared to other Plasmodium species and eukaryotes in…”
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Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study by Hamilton, William L, Amato, Roberto, van der Pluijm, Rob W, Jacob, Christopher G, Quang, Huynh Hong, Thuy-Nhien, Nguyen Thanh, Hien, Tran Tinh, Hongvanthong, Bouasy, Chindavongsa, Keobouphaphone, Mayxay, Mayfong, Huy, Rekol, Leang, Rithea, Huch, Cheah, Dysoley, Lek, Amaratunga, Chanaki, Suon, Seila, Fairhurst, Rick M, Tripura, Rupam, Peto, Thomas J, Sovann, Yok, Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Chau, Nguyen Hoang, Imwong, Mallika, Dhorda, Mehul, Vongpromek, Ranitha, Chan, Xin Hui S, Maude, Richard J, Pearson, Richard D, Nguyen, T, Rockett, Kirk, Drury, Eleanor, Gonçalves, Sónia, White, Nicholas J, Day, Nicholas P, Kwiatkowski, Dominic P, Dondorp, Arjen M, Miotto, Olivo

“…A multidrug-resistant co-lineage of Plasmodium falciparum malaria, named KEL1/PLA1, spread across Cambodia in 2008–13, causing high rates of treatment failure…”
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Ego-GNNs: Exploiting Ego Structures in Graph Neural Networks by Sandfelder, Dylan, Vijayan, Priyesh, Hamilton, William L.

“…Graph neural networks (GNNs) have achieved remarkable success as a framework for deep learning on graph-structured data. However, GNNs are fundamentally…”
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Shiga Toxin–Producing Escherichia coli Infection, Antibiotics, and Risk of Developing Hemolytic Uremic Syndrome: A Meta-analysis by Freedman, Stephen B., Xie, Jianling, Neufeld, Madisen S., Hamilton, William L., Hartling, Lisa, Tarr, Phillip I.

“…Background. Antibiotic administration to individuals with Shiga toxin–producing Escherichia coli (STEC) infection remains controversial. We assessed if…”
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Nanopore sequencing for malaria molecular surveillance: opportunities and challenges by Hamilton, William L., Ishengoma, Deus S., Parr, Jonathan B., Bridges, Daniel J., Barry, Alyssa E.

“…Nanopore-based sequencing platforms offer the potential for affordable malaria molecular surveillance (MMS) in resource-limited settings to track and…”
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Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification by Oyola, Samuel O, Ariani, Cristina V, Hamilton, William L, Kekre, Mihir, Amenga-Etego, Lucas N, Ghansah, Anita, Rutledge, Gavin G, Redmond, Seth, Manske, Magnus, Jyothi, Dushyanth, Jacob, Chris G, Otto, Thomas D, Rockett, Kirk, Newbold, Chris I, Berriman, Matthew, Kwiatkowski, Dominic P

“…Translating genomic technologies into healthcare applications for the malaria parasite Plasmodium falciparum has been limited by the technical and logistical…”
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