Search Results - "Hamilton, Tina L."

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment by Kirschner, Kristina, Chandra, Tamir, Kiselev, Vladimir, Flores-Santa Cruz, David, Macaulay, Iain C., Park, Hyun Jun, Li, Juan, Kent, David G., Kumar, Rupa, Pask, Dean C., Hamilton, Tina L., Hemberg, Martin, Reik, Wolf, Green, Anthony R.

“…Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely…”
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Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion by Kent, David G, Li, Juan, Tanna, Hinal, Fink, Juergen, Kirschner, Kristina, Pask, Dean C, Silber, Yvonne, Hamilton, Tina L, Sneade, Rachel, Simons, Benjamin D, Green, Anthony R

“…Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to…”
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JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease by Li, Juan, Kent, David G., Godfrey, Anna L., Manning, Harriet, Nangalia, Jyoti, Aziz, Athar, Chen, Edwin, Saeb-Parsy, Kourosh, Fink, Juergen, Sneade, Rachel, Hamilton, Tina L., Pask, Dean C., Silber, Yvonne, Zhao, Xiaodong, Ghevaert, Cedric, Liu, Pentao, Green, Anthony R.

“…Genomic regions of acquired uniparental disomy (UPD) are common in malignancy and frequently harbor mutated oncogenes. Homozygosity for such gain-of-function…”
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Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal by Shepherd, Mairi S., Li, Juan, Wilson, Nicola K., Oedekoven, Caroline A., Li, Jiangbing, Belmonte, Miriam, Fink, Juergen, Prick, Janine C.M., Pask, Dean C., Hamilton, Tina L., Loeffler, Dirk, Rao, Anjana, Schröder, Timm, Göttgens, Berthold, Green, Anthony R., Kent, David G.

“…Recent advances in single-cell technologies have permitted the investigation of heterogeneous cell populations at previously unattainable resolution. Here we…”
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Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage by Li, Juan, Prins, Daniel, Park, Hyun Jung, Grinfeld, Jacob, Gonzalez-Arias, Carlos, Loughran, Stephen, Dovey, Oliver M., Klampfl, Thorsten, Bennett, Cavan, Hamilton, Tina L., Pask, Dean C., Sneade, Rachel, Williams, Matthew, Aungier, Juliet, Ghevaert, Cedric, Vassiliou, George S., Kent, David G., Green, Anthony R.

“…Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET)…”
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STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion by Li, Juan, Williams, Matthew J., Park, Hyun Jung, Bastos, Hugo P., Wang, Xiaonan, Prins, Daniel, Wilson, Nicola K., Johnson, Carys, Sham, Kendig, Wantoch, Michelle, Watcham, Sam, Kinston, Sarah J., Pask, Dean C., Hamilton, Tina L., Sneade, Rachel, Waller, Amie K., Ghevaert, Cedric, Vassiliou, George S., Laurenti, Elisa, Kent, David G., Göttgens, Berthold, Green, Anthony R.

“…•STAT1 is essential for normal HSC function and maintenance of a MHCIIhi HSC subset that is less responsive to stress-induced proliferation.•MHCIIhi and…”
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Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition by Williams, Matthew J, Wang, Xiaonan, Bastos, Hugo P, Grondys-Kotarba, Gabriela, Wu, Qin, Jin, Shucheng, Johnson, Carys S, Mende, Nicole, Calderbank, Emily Francesca, Wantoch, Michelle, Park, Hyun Jung, Mantica, Giovanna, Hannah, Rebecca Louise, Wilson, Nicola K, Pask, Dean C, Hamilton, Tina L, Kinston, Sarah J, Asby, Ryan, Sneade, Rachel, Baxter, E Joanna, Campbell, Peter J, Vassiliou, George S, Laurenti, PhD, Elisa, Li, Juan, Gottgens, Berthold, Green, Anthony R

“…Adult haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells, a process regulated by extracellular cues…”
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T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity by DRYNAN, Lesley F, HAMILTON, Tina L, RABBITTS, Terence H

“…The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic…”
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Self-Renewal of Single Mouse Hematopoietic Stem Cells Is Reduced by JAK2V617F Without Compromising Progenitor Cell Expansion: e1001576 by Kent, David G, Li, Juan, Tanna, Hinal, Fink, Juergen, Kirschner, Kristina, Pask, Dean C, Silber, Yvonne, Hamilton, Tina L, Sneade, Rachel, Simons, Benjamin D, Green, Anthony R

“…Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to…”
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T cell tumorigenesis in Lmo2transgenic mice is independent of V-D-J recombinase activity by Drynan, Lesley F, Hamilton, Tina L, Rabbitts, Terence H

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