Search Results - "Hamilton, Shannon M"
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Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses
Published in Autism research (01-02-2011)“…Fragile X syndrome (FXS) is the most common inherited form of intellectual disability in humans. In addition to cognitive impairment, patients may exhibit…”
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Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome
Published in Human molecular genetics (01-08-2016)“…Mouse models of the transcriptional modulator Methyl-CpG-Binding Protein 2 (MeCP2) have advanced our understanding of Rett syndrome (RTT). RTT is a…”
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Fmr1 and Nlgn3 Knockout Rats: Novel Tools for Investigating Autism Spectrum Disorders
Published in Behavioral neuroscience (01-04-2014)“…Animal models are critical for gaining insights into autism spectrum disorder (ASD). Despite their apparent advantages to mice for neural studies, rats have…”
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Three-Dimensional Solution Structure of the Calcium-Signaling Protein Apo-S100A1 As Determined by NMR
Published in Biochemistry (Easton) (22-01-2002)“…S100A1, a member of the S100 protein family, is an EF-hand containing Ca2+-binding protein (93 residues per subunit) with noncovalent interactions at its dimer…”
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A simple statistical test to infer the causality of target/phenotype correlation from small molecule phenotypic screens
Published in Bioinformatics (01-02-2012)“…Motivation: Cell-based phenotypic screens using small molecule inhibitors is an important technology for early drug discovery if the relationship between the…”
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6
Multiple autism-like behaviors in a novel transgenic mouse model
Published in Behavioural brain research (17-03-2011)“…▶ The MALTT line shows multiple social behavior deficits and a progressive circling stereotypy. ▶ Juvenile MALTT mice exhibit minimal ultrasonic communication…”
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7
Modifying behavioral phenotypes in Fmr1 KO mice: genetic background differences reveal autistic‐like responses
Published in Autism research (01-02-2011)“…Fragile X syndrome (FXS) is the most common inherited form of intellectual disability in humans. In addition to cognitive impairment, patients may exhibit…”
Get full text
Journal Article