Search Results - "Hamilton, Nicola B."
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Do astrocytes really exocytose neurotransmitters?
Published in Nature reviews. Neuroscience (01-04-2010)“…Key Points Ca 2+ -dependent exocytosis of glutamate, D -serine and ATP from astrocytes has been proposed to add a novel layer of information processing to the…”
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2
Regulation of oligodendrocyte development and myelination by glucose and lactate
Published in The Journal of neuroscience (12-01-2011)“…In the gray matter of the brain, astrocytes have been suggested to export lactate (derived from glucose or glycogen) to neurons to power their mitochondria. In…”
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3
Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival
Published in eLife (13-06-2017)“…Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive…”
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4
Editorial: Journey to the Center of the Brain: Cell Physiology and Intercellular Communication in White Matter
Published in Frontiers in cellular neuroscience (14-03-2022)“…Omic approaches that analyze the gene expression profile of WM cells in great detail have revealed heterogeneity within cellular populations and suggested a…”
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5
Imaging pericytes and capillary diameter in brain slices and isolated retinae
Published in Nature protocols (01-02-2014)“…The cerebral circulation is highly specialized, both structurally and functionally, and it provides a fine-tuned supply of oxygen and nutrients to active…”
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Transient Receptor Potential Ankyrin-1 (TRPA1) Block Protects against Loss of White Matter Function during Ischaemia in the Mouse Optic Nerve
Published in Pharmaceuticals (Basel, Switzerland) (09-09-2021)“…Oligodendrocytes produce myelin, which provides insulation to axons and speeds up neuronal transmission. In ischaemic conditions, myelin is damaged, resulting…”
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Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia
Published in Nature (London) (28-01-2016)“…The myelin sheaths wrapped around axons by oligodendrocytes are crucial for brain function. In ischaemia myelin is damaged in a Ca(2+)-dependent manner,…”
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8
Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia
Published in Nature (London) (28-01-2016)“…Ischaemia damages nerve myelin by depriving neurons and their myelinating oligodendrocytes of oxygen and glucose; here it is shown that ischaemic damage is…”
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9
Capillary pericytes regulate cerebral blood flow in health and disease
Published in Nature (London) (03-04-2014)“…Increases in brain blood flow, evoked by neuronal activity, power neural computation and form the basis of BOLD (blood-oxygen-level-dependent) functional…”
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10
The role of TRP channels in white matter function and ischaemia
Published in Neuroscience letters (18-01-2019)“…•TRP channels are heterogeneously expressed in glial cells.•Here we summarise the suggested roles for glial TRP channels in physiology and pathology.•This is…”
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11
Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse
Published in The Journal of neuroscience (13-06-2012)“…Oligodendrocyte progenitor cells (OPCs) in the postnatal mouse corpus callosum (CC) and motor cortex (Ctx) reportedly generate only oligodendrocytes (OLs),…”
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12
Transient receptor potential Ankyrin‐1 (TRPA1) agonists suppress myelination and induce demyelination in organotypic cortical slices
Published in Glia (01-06-2023)“…Oligodendrocytes are highly specialized glial cells characterized by their production of multilayer myelin sheaths that wrap axons to speed up action potential…”
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13
Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length
Published in Glia (01-02-2017)“…Adjusting the thickness and internodal length of the myelin sheath is a mechanism for tuning the conduction velocity of axons to match computational needs…”
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14
Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion
Published in Proceedings of the National Academy of Sciences - PNAS (13-02-2018)“…Microglia, the brain’s innate immune cells, have highly motile processes which constantly survey the brain to detect infection, remove dying cells, and prune…”
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15
Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
Published in Nature neuroscience (01-04-2008)“…A defining feature of glial cells has been their inability to generate action potentials. We show here that there are two distinct types of morphologically…”
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16
Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter
Published in Glia (15-01-2008)“…Damage to oligodendrocytes caused by glutamate release contributes to mental or physical handicap in periventricular leukomalacia, spinal cord injury, multiple…”
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17
Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease
Published in Frontiers in neuroenergetics (2010)“…Because regional blood flow increases in association with the increased metabolic demand generated by localized increases in neural activity, functional…”
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18
Properties and Fate of Oligodendrocyte Progenitor Cells in the Corpus Callosum, Motor Cortex, and Piriform Cortex of the Mouse
Published in The Journal of neuroscience (13-06-2012)Get full text
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19
The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes
Published in Brain (London, England : 1878) (01-06-2009)“…Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's…”
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20
Proton-gated Ca.sup.2+-permeable TRP channels damage myelin in conditions mimicking ischaemia
Published in Nature (London) (28-01-2016)“…Ischaemia damages nerve myelin by depriving neurons and their myelinating oligodendrocytes of oxygen and glucose; here it is shown that ischaemic damage is…”
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